The treatment of migraines and tension-type headaches with intravenous and oral niacin (nicotinic acid): systematic review of the literature

Prousky, Jonathan E.; Seely, Dugald

doi:10.1186/1475-2891-4-3

Cited by 36 publications

(25 citation statements)

References 31 publications

(29 reference statements)

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“…The same vitamin B combination with a 1 mg dose of folic acid was not superior to placebo 185 . According to a systematic review 186 in which nine open studies were identified, niacin (nicotinic acid or vitamin B 3 ) might also have a prophylactic effect in migraine, but randomized controlled trials are lacking.…”

Section: Prophylactic Nutraceuticalsmentioning

confidence: 99%

The metabolic face of migraine — from pathophysiology to treatment

et al. 2019

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Migraine can be regarded as a conserved, adaptive response that occurs in genetically predisposed individuals with a mismatch between the brain's energy reserve and workload. Given the high prevalence of migraine, genotypes associated with the condition seem likely to have conferred an evolutionary advantage. Technological advances have enabled the examination of different aspects of cerebral metabolism in patients with migraine, and complementary animal research has highlighted possible metabolic mechanisms in migraine pathophysiology. An increasing amount of evidence-much of it clinical-suggests that migraine is a response to cerebral energy deficiency or oxidative stress levels that exceed antioxidant capacity and that the attack itself helps to restore brain energy homeostasis and reduces harmful oxidative stress levels. Greater understanding of metabolism in migraine offers novel therapeutic opportunities. In this Review , we describe the evidence for abnormalities in energy metabolism and mitochondrial function in migraine, with a focus on clinical data (including neuroimaging, biochemical, genetic and therapeutic studies), and consider the relationship of these abnormalities with the abnormal sensory processing and cerebral hyper-responsivity observed in migraine. We discuss experimental data to consider potential mechanisms by which metabolic abnormalities could generate attacks. Finally , we highlight potential treatments that target cerebral metabolism, such as nutraceuticals, ketone bodies and dietary interventions.

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Section: Prophylactic Nutraceuticalsmentioning

confidence: 99%

The metabolic face of migraine — from pathophysiology to treatment

et al. 2019

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“…Riboflavin in combination with CoQ 10 has been shown to reduce neurological episodes associated with migraine headaches (505). The combined approach augments complex I activity and has been used in clinical trials to demonstrate their combined effectiveness for preventing migraine attacks (459). Niacin has also been used as a supplement to boost mitochondrial energy metabolism by increasing substrate availability to complex I; in this way it might act to deter=reduce migraine headache (459).…”

Section: E Mitochondria and Dietary Supplementsmentioning

confidence: 99%

“…The combined approach augments complex I activity and has been used in clinical trials to demonstrate their combined effectiveness for preventing migraine attacks (459). Niacin has also been used as a supplement to boost mitochondrial energy metabolism by increasing substrate availability to complex I; in this way it might act to deter=reduce migraine headache (459). Clearly, the efficacies of these approaches remain to be resolved, their side effects remain under scrutiny, and they are limited by the fact that some studies have failed to make any association of migraine headache or dietary supplements with specific mitochondria deficits.…”

Section: E Mitochondria and Dietary Supplementsmentioning

confidence: 99%

Potential Therapeutic Benefits of Strategies Directed to Mitochondria

Camara

Lesnefsky

Stowe

2010

Antioxidants & Redox Signaling

165

226

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The mitochondrion is the most important organelle in determining continued cell survival and cell death. Mitochondrial dysfunction leads to many human maladies, including cardiovascular diseases, neurodegenerative disease, and cancer. These mitochondria-related pathologies range from early infancy to senescence. The central premise of this review is that if mitochondrial abnormalities contribute to the pathological state, alleviating the mitochondrial dysfunction would contribute to attenuating the severity or progression of the disease. Therefore, this review will examine the role of mitochondria in the etiology and progression of several diseases and explore potential therapeutic benefits of targeting mitochondria in mitigating the disease processes. Indeed, recent advances in mitochondrial biology have led to selective targeting of drugs designed to modulate and manipulate mitochondrial function and genomics for therapeutic benefit. These approaches to treat mitochondrial dysfunction rationally could lead to selective protection of cells in different tissues and various disease states. However, most of these approaches are in their infancy.

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“…Because it can dramatically increase blood flow and circulation within the brain, picamilon is used as a nootropic [2]. Also used for the treatment of depression, anxiety, and migraine [3], picamilon works by crossing the blood-brain barrier, after which it is hydrolyzed into GABA and nicotinic acid [4]. In addition, picamilon has extremely low toxicity and shows no allergenic or carcinogenic properties [1].…”

Section: Introductionmentioning

confidence: 99%