The Treatment of Malignant Hypertension Due To Ischemia of the Solitary Functioning Kidney

Robicsek, Francis; Citron, David S.; Taylor, Frederick H.; Sanger, Paul W.

doi:10.1177/000331976301400707

Cited by 9 publications

(1 citation statement)

References 5 publications

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“…For example, the latter, but not the former strains possess a rhamnose oligosaccharide porter (3.A.1.5.12), a melibiose permease (2.A.2.1.1) and a 2-O-α-mannosyl- d -glycerate porter (4.A.2.1.3). These first two oligosaccharides are constituents of glycolipid and glycoproteins found on the external surfaces of intestinal villus cells, while the last compound is a known intracellular osmolyte in some bacteria [92]. The extracellular strains, but not the intracellular strains, also have a xylose:H + symporter (2.A.1.1.3), a mannose PTS porter (4.A.2.1.6), a glucitol PTS transporter (4.A.4.1.2), and a galactitol PTS permease (4.A.5.1.3).…”

Section: Resultsmentioning

confidence: 99%

Transport proteins promoting Escherichia coli pathogenesis

Tang

Saier

2014

Microbial Pathogenesis

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Escherichia coli is a genetically diverse species infecting hundreds of millions of people worldwide annually. We examined seven well-characterized E. coli pathogens causing urinary tract infections, gastroenteritis, pyelonephritis and haemorrhagic colitis. Their transport proteins were identified and compared with each other and a non-pathogenic E. coli K12 strain to identify transport proteins related to pathogenesis. Each pathogen possesses a unique set of protein secretion systems for export to the cell surface or for injecting effector proteins into host cells. Pathogens have increased numbers of iron siderophore receptors and ABC iron uptake transporters, but the numbers and types of low-affinity secondary iron carriers were uniform in all strains. The presence of outer membrane iron complex receptors and high-affinity ABC iron uptake systems correlated, suggesting co-evolution. Each pathovar encodes a different set of pore-forming toxins and virulence-related outer membrane proteins lacking in K12. Intracellular pathogens proved to have a characteristically distinctive set of nutrient uptake porters, different from those of extracellular pathogens. The results presented in this report provide information about transport systems relevant to various types of E. coli pathogenesis that can be exploited in future basic and applied studies.

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Section: Resultsmentioning

confidence: 99%