The Treatment of Iron-Deficiency Anemia in Children with Iron-Dextran

Bartlett, William; Beatty, Eugene C.

doi:10.1001/archpedi.1957.04030070074007

Arch Pediatr Adolesc Med

1957

DOI: 10.1001/archpedi.1957.04030070074007

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The Treatment of Iron-Deficiency Anemia in Children with Iron-Dextran

William Bartlett¹,

Eugene C. Beatty²

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1962

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“…Intramusucular iron-dextran complex, on the other hand, is safe, effective and easily administered. In infants and children with iron-deficiency anaemia a few workers have shown that iron-dextran complex results in a marked, rapid haematological and clinical improvement and that it is free from any undesirable side-effects (2,6,19).…”

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The Effect of Intramuscular Iron‐dextran Complex1 on Iron‐deficiency Anaemia in Otherwise Ill Infants and Pre‐school Children

Lanzkowsky

1961

Acta Paediatrica

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Summary 1. One hundred and twenty‐five ill infants and children who were found to have iron‐deficiency anaemia were treated with intramuscular iron‐dextran complex with doses varying from 100 to 400 mg, concurrent with treatment for the presenting illness. 2. The mean haemoglobin levels before treatment ranged from 8.91 g% to 9.61 g% in the various age groups; at 3 weeks after the injection of iron the mean haemoglobin levels were found to range between 10.12 g% and 10.80 g% and at 6 weeks after injection the mean haemoglobin levels had risen further to range between 10.75 g% and 12.0 g%. There was thus an approximate general rise of 2 g% of haemoglobin in 6 weeks. Clinically the beneficial effects were quite striking, and occurred often within days. 3. The results of this investigation indicate that intramuscular iron‐dextran complex can significantly raise the haemoglobin level in infants and children who have iron‐deficiency anaemia with a variety of associated illnesses, of all degrees of severity, and of largely undetermined duration. In addition, iron‐dextran complex was found to be safe and easy to administer. 4. The factors influencing rate of recovery from iron‐deficiency anaemia after intramuscular iron‐dextran complex, the theoretical dangers of iron overload and the possible production of sarcomata in iron‐injected tissue are discussed.

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The Effect of Intramuscular Iron‐dextran Complex1 on Iron‐deficiency Anaemia in Otherwise Ill Infants and Pre‐school Children

Lanzkowsky

1961

Acta Paediatrica

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The Effect of Intramuscular Iron‐dextran Complex on Iron‐deficiency Anaemia in Otherwise Ill Infants and Pre‐school Children1

Carlström

1959

Acta Paediatrica

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Summary 1. One hundred and twenty‐five ill infants and children who were found to have iron‐deficiency anaemia were treated with in tramuscular iron‐dextran complex with doses varying from 100 to 400 mg, con‐current with treatment for the presenting illness. 2. The mean haemoglobin levels before treatment ranged from 8.91 g%to 9.61 g%in the various age groups; at 3 weeks after the injection of iron the mean haemoglobin levels were found to range between 10.12 g%and 10.80 g%and at 6 weeks after injection the mean haemoglobin levels had risen further to range between 10.75 g%and 12.0 g%. There was thus an approximate general rise of 2 g %of haemoglobin in 6 weeks. Clinically the beneficial effects were quite striking, and occurred often within days. 3. The results of this investigation indicate that intramuscular iron‐dextran complex can significantly raise the haemoglobin level in infants and children who have iron‐deficiency anaemia with a variety of associated illnesses, of all degrees of severity, and of largely undetermined duration. In addition, iron‐dextran complex was found to be safe and easy to administer. 4. The factors influencing rate of recovery from iron‐deficiency anaemia after in tramuscular iron‐dextran complex, the theoretical dangers of iron overload and the possible production of sarcomata in iron‐injected tissue are discussed.

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Leukemoid Reaction to Parenteral Iron-Dextran Complex

Samuels¹

1962

JAMA

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The Treatment of Iron-Deficiency Anemia in Children with Iron-Dextran

Cited by 3 publications

References 1 publication

The Effect of Intramuscular Iron‐dextran Complex1 on Iron‐deficiency Anaemia in Otherwise Ill Infants and Pre‐school Children

The Effect of Intramuscular Iron‐dextran Complex1 on Iron‐deficiency Anaemia in Otherwise Ill Infants and Pre‐school Children

The Effect of Intramuscular Iron‐dextran Complex on Iron‐deficiency Anaemia in Otherwise Ill Infants and Pre‐school Children1

Leukemoid Reaction to Parenteral Iron-Dextran Complex

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