The Treatment of Gallstone Disease

Gutt, Carsten N.; Schläfer, Simon; Lammert, Frank

doi:10.3238/arztebl.2020.0148

Cited by 96 publications

(124 citation statements)

References 47 publications

(35 reference statements)

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“…Otherwise, prophylactic UDCA (500 g/d) may prevent stone formation for those patients with post-bariatric surgery [23]. A randomized controlled trial (RCT) study published in 2003 found a significantly reduced risk of gallstones formation within 24 months after restrictive gastric bypass surgery (8% vs. 30%) [24].…”

Section: Medical Treatmentmentioning

confidence: 99%

Cholelithiasis: A Brief Review on Diagnostic Approach and Management in Clinical Practice

2020

ARGH

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Cholelithiasis is one of the most prevalent diseases in gastroenterology. There are many factors in cholelithiasis, such as genetic, lack of physical activity, obesity, dietary, age, and other comorbidities. Commonly, cholelithiasis occurs asymptomatically; however, Murphy's sign is one of the most frequent pathognomonic findings in abdominal examination. Ultrasonography is known as the gold standard imaging examination in diagnosing cholelithiasis. The management of cholelithiasis can be divided into two categories, such as medical treatment and surgical treatment, which depends on the patient's condition.

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Section: Medical Treatmentmentioning

confidence: 99%

Cholelithiasis: A Brief Review on Diagnostic Approach and Management in Clinical Practice

2020

ARGH

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“…Other factors that affect the hepatic production of cholesterol, stasis/inflammation, bile acid production, or intestinal absorption of cholesterol and bile acids also contribute to GD development. Increasing evidence also points to genetic factors as being important for GD development [ 4 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Association of apolipoprotein B XbaI (rs693) polymorphism and gallstone disease risk based on a comprehensive analysis

Zhu

Feng

2021

Genes and Environ

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Background Our aim was to investigate the association between XbaI gene polymorphisms in the apolipoprotein B (APOB) gene and gallstone disease (GD) risk through a comparison of the allele and genotype distribution frequencies at this site using meta-analysis. Methods A literature search was performed using PubMed and Wanfang through Jun 1, 2020. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of associations. Results After a comprehensive search, 14 different articles that met the inclusion criteria were selected, with 1583 cases and 1794 controls. Individuals carrying the A-allele or AA genotype of the rs693 polymorphism were determined to possibly have an increased risk of GD. For example, there was a significant relationship between the rs693 polymorphism and increased GD risk in the whole group (OR: 1.40, 95 % CI: 1.05–1.87 in the allelic contrast model), the Asian population (OR: 1.58, 95 % CI: 1.48–2.84 in the heterozygote model), and the hospital-based source of the control (OR: 1.79, 95 % CI: 1.13–2.84 in the dominant model). Conclusions This study suggests that the APOB rs693 polymorphism is potentially associated with GD susceptibility, which might offer a detection marker for use in future large scale clinic research.

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“…The prevalence of gallstones is also very common in the upper and middle socioeconomic class due to their dietary habits and obesity. The treatment of gallstone depends upon how many symptoms a patient is showing [ 9 , 10 ]. For symptomatic gallstones, surgery is performed to remove gallstones from the gallbladder.…”

Section: Introductionmentioning

confidence: 99%

Symptomatic Gallstones in Young Patients Under the Age of 30 Years

Ali¹,

Perveen²,

Khan³

et al. 2021

Cureus

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IntroductionGallstones are deposits of digestive fluid that is hardened into small pellets. Gallstones can be symptomatic or asymptomatic. The present study assessed the sociodemographic and clinical characteristics of patients under the age of 30 years old with symptomatic gallstones. MethodologyA prospective, observational study was conducted at Surgical Unit-3, at Jinnah Postgraduate Medical Centre (JPMC), Pakistan, from July 2020 to July 2021. All patients suspected of having gallstone disease underwent ultrasonic examination. A diagnosis of gallstone disease was made if the gallbladder showed a hyperechoic mass casting a posterior acoustic shadow, with a change of position. All of the patients with gallstone disease were hospitalized. The patients were asked about their age, past history (with special emphasis on last pregnancy and years of oral contraceptive use, if any), socioeconomic status, and other demographic data. The patients were treated with a cholecystectomy, either laparoscopic or open. Postcholecystectomy complications, if any, were recorded. ResultsA total of 210 patients under the age of 30 years were included. The mean age of patients was 25 ± 3 years. The majority of the population were females, i.e., 170 (81%). Upon assessing the risk factors, it was found that 31.84% of the female patients had used oral contraceptives, 32.96% were pregnant at the time of presentation, 20.48% had diabetes mellitus, and 27.14% had a history of gallstones. Furthermore, it was found that about 114 (54.29%) patients were overweight with a body mass index (BMI) of 25-30 kg/m 2 . High triglyceride levels and high cholesterol levels were found in 108 (51.43%) and 115 (54.76%) of the patients, respectively, indicating a link between symptomatic gallstones and younger age. ConclusionOur study indicated that young people are prone to symptomatic gallstones. The rate of disease was considerably high among females and in patients with high cholesterol and triglyceride levels and abnormal body mass index. Further exploratory studies are needed to determine the cause of gallstones.

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The Treatment of Gallstone Disease

Cited by 96 publications

References 47 publications

Cholelithiasis: A Brief Review on Diagnostic Approach and Management in Clinical Practice

Cholelithiasis: A Brief Review on Diagnostic Approach and Management in Clinical Practice

Association of apolipoprotein B XbaI (rs693) polymorphism and gallstone disease risk based on a comprehensive analysis

Symptomatic Gallstones in Young Patients Under the Age of 30 Years

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