The treatment of dysmenorrhea with testosterone propionate

Salmon, Udall J.; Geist, Samuel H.; Walter, Robert I.

doi:10.1016/s0002-9378(39)90827-6

Cited by 23 publications

(1 citation statement)

References 16 publications

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“…For several years we have fostered the theory that androgens play an important role in the steroid sex hormone physiology of the human female, modifying and balancing the action of the gynecogenic hormones (1, 2, 3). We have based the rationale for the use of androgens in the treatment of certain types of menometrorrhagia (4, 5), dysmenorrhea (6), and premenstrual tension (1, 7) upon this theory. It appears from the studies herein reported that the endogenous androgens in the mature human female may have still another function, namely, to sensitize both the psychic and somatic components of the sexual mechanism so that the individual is emotionally receptive to excitation and somatically sensitive to sexual stimulation.…”

Section: Discussionmentioning

confidence: 99%

Effect of Androgens upon Libido in Women

Salmon

Geist

1943

The Journal of Clinical Endocrinology & Metabolism

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Section: Discussionmentioning

confidence: 99%

Effect of Androgens upon Libido in Women

Salmon

Geist

1943

The Journal of Clinical Endocrinology & Metabolism

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The Biologic Effects of Androgen (Testosterone Propionate) in Women

Geist¹,

Salmon²,

Gaines³

et al. 1940

JAMA

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In the past year several publications have appeared reporting the use of synthetic androgen (testosterone propionate) in functional gynecologic conditions.1 The therapeutic results in many cases have been striking, and the question arises as to whether the use of androgen in women is to be considered as purely empiric or as a form of hormonal substitution therapy, correcting a preexisting deficiency. It is of considerable importance, therefore, to know what the biologic properties of androgen are in women. Unfortunately, the majority of the reports on the use of this substance in women consist of purely clinical studies. However, in a few instances attempts were made to determine objectively the biologic effects of male hormone administered to women. Thus it has been shown that testosterone propionate inhibits the gonadotropic hyperactivity of the hypophysis of a castrate woman,2 suppresses menstruation,3 produces atrophy of the endometrium4 and at the same time induces estrogen deficiency changes in the vaginal smear5 with disappearance of the glycogen ;6 it also inhibits peristalsis of the fallopian tubes.7 In addition, it has been noted that in some women signs of virilism appear during the course of treatment with testosterone; viz., enlarge¬ ment of the clitoris,8 acne, hoarseness and hirsutism.9Because of the fact that testosterone propionate can pro¬ duce such striking somatic effects in women and in view of the current interest in testosterone as a therapeutic agent, we report our experience with the use of testo¬ sterone propionate in a series of twenty-five women with normal menstrual cycles. This group was selected out of a larger group of 153 women that have been treated with testosterone propionate during the past two and one half years. The large group consisted of patients with functional menometrorrhagia, menometrorrhagia associated with fibroids, endometriosis, functional dysmenorrhea, mastalgia and premenstrual tension. The results of our experience with testosterone propionate as a therapeutic agent in the treatment of functional bleeding (Geist, Salmon and Gaines 9) and dysmenorrhea 10 have already been reported. Reports on the other conditions will be published. Here we will describe the biologic effects of different doses of testosterone propionate administered over varied periods of time to women with regular menstrual cycles. THE MALE SEX HORMONES (ANDROGENS)Because of the recent developments in the chemistry of the steroid sex hormones, new terms have been intro¬ duced to designate the different compounds of male sex hormone that have been identified. The term "andro¬ gen" is used to designate all compounds that have the characteristic properties of male sex hormone in con¬ tradistinction to the estrogens, which are female sex hormones. Three androgens have been found to exist in the organism, androsterone, transdehydro-androsterone and testosterone. The last-mentioned androgen is believed to be the physiologically active substance found in the testes, and the first two are the excretory ...

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Syndrome of Major Menstrual Molimina With Hypermenorrhea Alleviated by Testosterone Propionate

Greenblatt¹

1940

JAMA

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The treatment of dysmenorrhea with testosterone propionate

Cited by 23 publications

References 16 publications

Effect of Androgens upon Libido in Women

Effect of Androgens upon Libido in Women

The Biologic Effects of Androgen (Testosterone Propionate) in Women

Syndrome of Major Menstrual Molimina With Hypermenorrhea Alleviated by Testosterone Propionate

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