The Treatment of Dry Eyes with Na Hyaluronate (Healon??)

Polack, Frank M.; McNiece, M. T.

doi:10.1097/00003226-198201020-00007

Cited by 55 publications

(35 citation statements)

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“…[1][2][3][4] Current medical therapies for the management of dry eye include tear supplementation, retention, stimulation, anti-inflammatory agents, and environmental strategies. 5 A topical application of sodium hyaluronate has been shown to confer both subjective and objective improvement in patients with dry eye syndrome arising from Sjö gren's syndrome or keratoconjunctivitis sicca, [6][7][8][9] and thus, in practice, it is widely used in the treatment of these patients. Sodium hyaluronate has also been reported to provide better protection of the corneal epithelium against dryness than hydroxyethylcellulose or phosphate-buffered saline.…”

Section: Introductionmentioning

confidence: 99%

Clinical evaluation of the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome: a prospective, randomized, multicenter study

Kamiya

Nakanishi

Ishii

et al. 2012

Eye

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Purpose To assess the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome. Methods This study evaluated 64 eyes of 32 patients (age: 62.6±12.8 years (mean±SD)) in whom treatment with 0.1% sodium hyaluronate was insufficiently responsive. The eyes were randomly assigned to one of the two regimens in each patient: topical administration of sodium hyaluronate and diquafosol tetrasodium in one eye, and that of sodium hyaluronate in the other. Before treatment, and 2 and 4 weeks after treatment, we determined tear volume, tear film breakup time (BUT), fluorescein and rose bengal vital staining scores, subjective symptoms, and adverse events. Results We found a significant improvement in BUT (P ¼ 0.049, Dunnett test), fluorescein and rose bengal staining scores (P ¼ 0.02), and in subjective symptoms (P ¼ 0.004 for dry eye sensation, P ¼ 0.02 for pain, and P ¼ 0.02 for foreign body sensation) 4 weeks after treatment in the diquafosol eyes. On the other hand, we found no significant change in these parameters after treatment in the control eyes. Conclusions In dry eyes, where sodium hyaluronate monotherapy was insufficient, diquafosol tetrasodium was effective in improving objective and subjective symptoms, suggesting its viability as an option for the additive treatment of such eyes.

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Section: Introductionmentioning

confidence: 99%

Clinical evaluation of the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome: a prospective, randomized, multicenter study

Kamiya

Nakanishi

Ishii

et al. 2012

Eye

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“…Several cell types, such as those of the corneal epithelium, keratocytes, endothelial cells, iris pigmented epithelium or lens epithelium, have been suggested to be capable of producing endogenous HA [32][33][34]. In alkali-wounded eyes and other ocular surface disorders, different concentrations of Na-HA have been applied either clinically or experimentally [9,[15][16][17][18][19][20]35]. Na-HA has been reported to provide better protection of the corneal epithelium and endothelium [15][16][17][18][19][20] to stimulate corneal epithelial migration and proliferation [9,13,35] and to enhance hemidesmosome morphogenesis [12].…”

Section: Discussionmentioning

confidence: 99%

“…HA is widely distributed in connective tissues as an important constituent of the extracellular matrix [14]. Numerous studies have been postulated that topically applied Na-HA has positive effects on epithelial healing in various types of corneal injury and ocular surface disorders [9,12,13,[15][16][17][18][19][20]. Previously we showed that topically applied 1% Na-HA both enhanced the formation of hemidesmosomes in epithelial healing after n-heptanol-induced wounds and stimulated the initial epithelial healing in alkali wounds [9,12].…”

Section: Introductionmentioning

confidence: 99%

Effect of Na-Hyaluronan on Stromal and Endothelial Healing in Experimental Corneal Alkali Wounds

et al. 1999

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The healing of stroma and endothelium after a standardized corneal alkali wound was evaluated in sodium-hyaluronan (Na-HA)-treated eyes. Alkali wounds were produced in one eye of each rabbit by applying a 5.5-mm round filter paper soaked in 1 N NaOH onto the central cornea for 60 s. Eyes were then treated with either 1% Na-HA (the treatment group) or phosphate-buffered saline (the control group) 4 times per day for 3 weeks. Endothelial wound morphometry was performed after alizarin red and trypan blue staining, while stromal healing was assessed by counting polymorphonuclear leukocytes (PMNs) and keratocytes in the central and marginal wound areas. During the early healing period the stroma treated with Na-HA had less PMNs than that of the control group. The size of the endothelial defect area measured 5 days after injury was significantly smaller in the Na-HA group than in the control corneas. The present findings indicate that topically applied 1% Na-HA affects stromal and endothelial healing during the early repair process after corneal alkali wounds.

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“…[3][4][5][6] HA has also been reported to protect the corneal epithelium. 7 A randomised, crossover study has shown that a preservative-free, 0.1% (w/v) solution of sodium hyaluronate, manufactured by a process of continuous fermentation (Vitrolife UK Ltd) performs significantly better than saline in both subjective and objective tests in patients with severe dry eye.…”

Section: Introductionmentioning

confidence: 99%

A randomised, crossover, multicentre study to compare the performance of 0.1% (w/v) sodium hyaluronate with 1.4% (w/v) polyvinyl alcohol in the alleviation of symptoms associated with dry eye syndrome

McDonald¹,

Kaye

Figueiredo

et al. 2002

Eye

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The Treatment of Dry Eyes with Na Hyaluronate (Healon??)

Cited by 55 publications

References 0 publications

Clinical evaluation of the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome: a prospective, randomized, multicenter study

Clinical evaluation of the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome: a prospective, randomized, multicenter study

Effect of Na-Hyaluronan on Stromal and Endothelial Healing in Experimental Corneal Alkali Wounds

A randomised, crossover, multicentre study to compare the performance of 0.1% (w/v) sodium hyaluronate with 1.4% (w/v) polyvinyl alcohol in the alleviation of symptoms associated with dry eye syndrome

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