The treatment of barbiturate poisoning with or without analeptics

Eckenhoff, James E.; W, Dam

doi:10.1016/0002-9343(56)90211-x

Cited by 34 publications

(8 citation statements)

References 14 publications

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“…Analeptics were not used in any patient which is in agreement with Eckenhoff and Dam (1956), Clemmesen and Nilsson (1961) and Myschetzh.y (19tH). It IS firmly believed that the best treatment for drug depression uf respil ation is artificial ventilation.…”

Section: Associated Diseasesmentioning

confidence: 74%

Severe Drug Overdose: Results of Treatment

1975

Anaesth Intensive Care

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The incidence and management of severe drug overdose patients over a five-year period is presented, together with results and complications. Emphasis is placed on the importance of conservative measures with minimal need for more aggressive methods of treatment. A study of all overdose patients admitted to the Intensive Care ward of the Alfred Hospital, Melbourne was carried out over a five-year period from February 1969 to February 1974. MATERIAL 159 47 112 number represents only 2•8 per cent of the total number of overdose patients seen at the Casualty Department of the hospital.

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Section: Associated Diseasesmentioning

confidence: 74%

Severe Drug Overdose: Results of Treatment

1975

Anaesth Intensive Care

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“…The clinical management of pharmacologically produced respiratory depression is still probably best accomplished not by placing reliance upon respiratory stimulants or analeptics, but rather by careful attention to maintenance of a clear airway with artificially assisted or controlled respirations and with meticulous general supportive measures to assure normal fluid, electrolyte, and caloric balance, the only pharmacologic agents of value being specific antagonists (nalorphine, levallorphan) when the depression is due to narcotics. 8 The present report, therefore, does not necessarily support the use of analeptics in the treatment of respiratory depression, but it demonstrates how one particular analeptic, ethamivan, produces its respiratory effect.…”

Section: Discussionmentioning

confidence: 99%

Ethamivan and the Ventilatory Response to Carbon Dioxide in Depressed Man

Rockwell¹,

Greene

Marx

1964

Survey of Anesthesiology

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Because the means by which analeptics stimulate respiration is generally unknown, a study was instituted to evaluate the effect of ethamivan (Emivan) on the threshold response of the human respiratory center to carbon dioxide. Alveolar carbon dioxide tensions and minute respiratory volumes were measured in normal subiects prior to the administration of any drug, folloWing elevation of the threshold of the respiratory center to carbon dioxide produced by meperidine and thiopental, and, finally, following the intravenous IUlministration of ethamivan.The effects of ethamivan were tested only in subiects whose respiration had been depressed because of the suggested use of analeptics in such states. The results showed that in the presence of respiratory depression, ethamivan produced a prompt and significant increase in ventilation but that with the dosage tested ethamivan did not fully restore ventilation to normal control value. Ethamivan produced this effect by lowering the previously elevated threshold response of the respiratory center to carbon dioxide rather than by inducing hyperventilation through other neurophysiologic mechanisms.

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“…For five and seven days, respectively, in the latter two cases, the attending physicians maintained constant but conservative therapy such as described by Nilson 5 and Echenhofl and Dam. 20 Subsequently both patients were in stage 2, with blood levels of 8.2 to 8.8 mg. barbiturate per lOO ml. of blood.…”

Section: A-60mentioning

confidence: 99%

Forensic Medicine

Sunshine

1957

Postgraduate Medicine

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The treatment of barbiturate poisoning with or without analeptics

Cited by 34 publications

References 14 publications

Severe Drug Overdose: Results of Treatment

Severe Drug Overdose: Results of Treatment

Ethamivan and the Ventilatory Response to Carbon Dioxide in Depressed Man

Forensic Medicine

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