The Treatment of Bacillary Urinary Infections with Chloromycetin,

Chittenden, George E.; Sharp, E. A.; Heide, E. C. Vonder; Bratton, A. C.; Glazko, Anthony J.; Stimpert, F.D.

doi:10.1016/s0022-5347(17)69002-5

Cited by 13 publications

(5 citation statements)

References 13 publications

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“…The data presented in this study on the persistence of chloramphenicol and its metabolic products in the serum of patients with severe renal or hepatic disease confirm and extend observations made in previous investigations in normal man (4,5,7). The observation that the serum half-life of microbially active drug is not significantly prolonged in anuric patients indicates that the rate of removal of the drug by conversion to its metabolic products is virtually unaffected by renal disease.…”

Section: Discussionsupporting

confidence: 89%

“…t An abstract of this paper has been published (1). amphenicol by the oral or parenteral route, 75 to 90 per cent of the administered dose may be recovered in the urine of patients who have normal renal function (4,5). From 5 to 15 per cent of the recovered drug is in the microbially active form; the remainder is composed largely of an inactive monoglucuronide conjugate and to a lesser extent products of hydrolysis (6).…”

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confidence: 99%

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Persistence of Antibiotics in Blood of Patients With Acute Renal Failure. Ii. Chloramphenicol and Its Metabolic Products in the Blood of Patients With Severe Renal Disease or Hepatic Cirrhosis*†

Kunin¹,

Glazko²,

Finland³

1959

J. Clin. Invest.

159

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Section: Discussionsupporting

confidence: 89%

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confidence: 99%

Persistence of Antibiotics in Blood of Patients With Acute Renal Failure. Ii. Chloramphenicol and Its Metabolic Products in the Blood of Patients With Severe Renal Disease or Hepatic Cirrhosis*†

Kunin¹,

Glazko²,

Finland³

1959

J. Clin. Invest.

159

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“…Its presence in the bile after an interval of two hours has been reported by Gruhzit, Fisken, Reutner, and Martino (1949), by Glazko, Wolf, and Dill (1949), and by Long, Bliss, Schoenbach, Chandler, and Bryer (1950). In the following paper some details are given of its excretion in the bile.…”

mentioning

confidence: 64%

“…It should not be assumed that the chloramphenicol excreted in the bile is necessarily all active, for Chittenden, Sharp, Vonder Heide, Bratten, Glazko, and Stimpert (1949) demonstrated that only 15% of the chloramphenicol excreted in urine, as estimated calorimetrically, is in an active form. It is probable, therefore, that part of the chloramphenicol excreted with the bile is also inactive.…”

Section: Discussionmentioning

confidence: 99%

Chloramphenicol Excretion in the Bile

Danopoulos¹,

Angelopoulos²,

Ziordrou³

et al. 1954

British Journal of Pharmacology and Chemotherapy

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It is well known that chloramphenicol is readily absorbed from the gastro-intestinal tract, and appears in the blood shortly after oral administration. Its presence in the bile after an interval of two hours has been reported by Gruhzit, Fisken, Reutner, and Martino (1949), by Glazko, Wolf, and Dill (1949), and by Long, Bliss, Schoenbach, Chandler, and Bryer (1950). In the following paper some details are given of its excretion in the bile. METHODSAbsorption from the Portal Vein by the Liver.-After a 12-hr. fast, dogs of 8 and 13 kg. were given 80-100 mg. of chloramphenicol by mouth in a sufficient quantity of water. Half an hour later the abdomen was opened under chloralose anaesthesia, and blood samples were taken from the portal and hepatic veins.Excretion in the Bile of Dogs.-After ligation and section *of the common bile duct a biliary fistula was established. The general condition of the dogs remained good for a long period, for, by licking and swallowing some of the escaping bile, they obtained a 1024 a considerable quantity by mouth. The fistula was catheterized daily with a glass 512 catheter to maintain patency. The bile flow was continuous, indicating bile of 256-hepatic and not gall-bladder origin. About E a month after operation the fistula was well m 128-organized and no bleeding followed a catheterization.O 64-In each experiment chloramphenicol u was administered by stomach tube or oral Z 32-syringe, and at the same time a rubber I catheter was inserted ihto the fistula. E 16-Bile was flowing continuously, and blood C and bile samples were collected at intervals°8-after administration. The chloramphenicol I estimations were made by the colorimetric 4-method described by Bessman and Stevens (1950).2-Excretion in Human Bile.-A dose of 1 250 mg. was given to a man weighing 46 kg. with a post-operative biliary fistula: blood and bile samples were collected after

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“…1 11. Chloramphenicol has been shown to be rapidly inactivated in vivo by conjugation with glucuronic acid, and this largely accounts for the recovery in urine of man of only 5 1 5 % of microbially active, unconjugated drug (2,3,4). Acad.…”

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confidence: 99%