The treatment of arthritis with a lipid extract of Perna canaliculus: a randomized trial

Furan fatty acid as an anti-inflammatory component from the green-lipped mussel Perna canaliculus

“…The development of a natural remedy for the management of arthritis that will not only replace nonsteroidal anti-inflammatories (NSAIDs) as the standard treatment for all types of arthritis but also treat the condition successfully, without any known side effects, is being eagerly pursued (1). Therefore, numerous studies have been published on the lipid composition of the extract (2-4), its complex mode of action (5)(6)(7)(8), activity in animal models (9,10), and efficacy in controlling osteoarthritis (11,12) and moderate asthma in patients (13). However, the active component from the mussel is a lipid rich in polyunsaturated fatty acids (PUFAs) and is therefore prone to activation of degrading enzymes including phospholipases and lipoxygenases (14,15) after cell damage, unless it is stored and transported properly.…”

Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial

“…The lipid extract Lyprinol is rich in eicosapentaenoic acid and docosahexanoic acid, v-3 fatty acids that inhibit the metabolism of arachidonic acid [4]. This extract is effective in reducing pain, swelling and stiffness and in improving the functional index in patients with rheumatoid arthritis and osteoarthritis [5,6]. Its efficacy in the treatment of airway inflammation is unknown.…”

An Evidence-Based Systematic Review of Green-Lipped Mussel (Perna canaliculus) by the Natural Standard Research Collaboration

“…r Asthma: Two capsules of Lyprinol R (containing 50 mg of omega-3 polyunsaturated fatty acids and 100 mg olive oil per capsule) has been used twice daily for eight weeks for steroid-naïve atopic asthma (Emelyanov et al, 2002). r Osteoarthritis: Green-lipped mussel has been used in the following doses to treat osteoarthritis: 1,050 mg mussel extract (three capsules) daily for 3-6 months (Gibson, Gibson, Conway, & Chappell, 1980), six capsules Seatone daily (no details given) for six months (Audeval & Bouchacourt, 1986), 210 mg Lyprinol R (or 1,150 mg mussel powder) daily for 3-6 months (Gibson & Gibson, 1998), or four capsules Lyprinol R daily (dose not specified) for two months followed by four months of two capsules daily (Lau et al, 2004). Lyprinol R was used as a 5-LOX inhibitor for osteoarthritis at a dosage of two capsules twice daily for 4-8 weeks (Cho et al, 2003).…”

“…r Rheumatoid arthritis: Mussel extract capsules have been used daily for 90 days (Gibson et al, 1980). A 210 mg Lyprinol R has been used daily for three to six months (Gibson & Gibson, 1998 acids") has been used for 12 weeks (Gruenwald, Graubaum, Hansen, & Grube, 2004).…”