The Treatment of Abnormal Uterine Bleeding with Androgens

Salmon, Udall J.; Geist, Samuel H.; Gaines, Joseph A.; Walter, Robert I.

doi:10.1016/s0002-9378(16)40839-2

Cited by 14 publications

(7 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As early as 1941, it was shown that androgens are synthesized in the female and are the precursors of estrogen biosynthesis[4,5]. Salmon noted that:…”

Section: Testosterone Therapy In Patients With Gynecological and Sexumentioning

confidence: 99%

“…During this same year, Salmon et al. and Geist and Salmon published seminal articles and stated that, although helpful, animal studies were not necessary for the justification of treating women with testosterone [5,49]:…”

Section: Testosterone Therapy Of Abnormal Uterine Bleedingmentioning

confidence: 99%

“…It was felt, therefore, since testosterone inhibits both the gonadotropic activity of the pituitary (which appears to be the primary factor in the cycle of events which culminates in uterine bleeding) and the endometrium (which is the end organ involved in the bleeding process) that possibly abnormal uterine bleeding could be controlled by utilizing this antigynecogenic property of testosterone. [5]…”

Section: Testosterone Therapy Of Abnormal Uterine Bleedingmentioning

confidence: 99%

See 2 more Smart Citations

Testosterone Therapy in Women with Gynecological and Sexual Disorders: A Triumph of Clinical Endocrinology from 1938 to 2008

Traish

Feeley

Guay

2009

The Journal of Sexual Medicine

View full text Add to dashboard Cite

Introduction Although the term “medicalization” has been used by some to describe contemporary testosterone use in women with sexual disorders and testosterone deficiency syndrome, testosterone therapy for women with various gynecological and sexual disorders has been practiced since the late 1930s. Aim The study aimed to perform a historical review of testosterone use in women with sexual and gynecological disorders. This review is necessary to bridge important knowledge gaps in the clinical use of testosterone in women with sexual health concerns and to provoke new thoughts and understanding of the multidisciplinary role of testosterone in women’s overall health. Methods Review of medical literature on androgen therapy in women was carried out from 1938 through 2008. Results Approximately 70 years ago, clinicians from various disciplines relied on personal experience and clinical observations for outcome assessment of testosterone therapy in women. These early reports on testosterone use in women with sexual medical problems served as a foundation for the development of contemporary approaches and subsequent testosterone treatment regimens. Testosterone use was reported for sexual dysfunction, abnormal uterine bleeding, dysmenorrhea, menopausal symptoms, chronic mastitis and lactation, and benign and malignant tumors of the breast, uterus, and ovaries. Conclusions Health-care professionals engaged in the management of women’s health issues have observed the benefits of androgen therapy throughout much of the 20th century. Despite this clinical use of testosterone in women for more than seven decades, contemporary testosterone therapy in women is hotly debated, misunderstood, and often misrepresented in the medical community.

show abstract

“…As early as 1941, it was shown that androgens are synthesized in the female and are the precursors of estrogen biosynthesis[4,5]. Salmon noted that:…”

Section: Testosterone Therapy In Patients With Gynecological and Sexumentioning

confidence: 99%

Section: Testosterone Therapy Of Abnormal Uterine Bleedingmentioning

confidence: 99%

Section: Testosterone Therapy Of Abnormal Uterine Bleedingmentioning

confidence: 99%

See 1 more Smart Citation

Testosterone Therapy in Women with Gynecological and Sexual Disorders: A Triumph of Clinical Endocrinology from 1938 to 2008

Traish

Feeley

Guay

2009

The Journal of Sexual Medicine

View full text Add to dashboard Cite

show abstract

“…If more than 500 mg. is administered during the course of one menstrual cycle, the secretion of gonadotropic hormone by the pituitary is suppressed.i'': 17 ovulation is inhibited.v !" the production of estrogens and progesterone by the ovary is stopped" 3,10,19 and the usual cyclical morphological changes in the endometrium fail to occur, the endometrium and vaginal mucosa revealing varying degrees of involution indicating estrogen deficiency.v F''? "…”

Section: Discussionmentioning

confidence: 99%

LXXXIX The Effect of Androgen Therapy on the Voice and Vocal Cords of Adult Women

Goldman¹,

Salmon²

1942

Ann Otol Rhinol Laryngol

Self Cite

View full text Add to dashboard Cite

During the course of administering androgens in the treatment of female endocrine disorders, the observation was made that a number of the women developed changes in the character of the voice 'and in the physical appearance of the larynx whichcould not be attributed to anything but the hormone therapy.i" In view of the increasing use of male sex hormone, in the treatment of endocrinopathic gynecologic disorders, it seemed important to study these laryngeal changes and determine whether they can be prevented.The observations in this communication were made from a series of over 400 patients who were treated with various androgens; viz., testosterone propionate administered intramuscularly, methyl testosterone orally, testosterone by implantation of pellets, and testosterone in solution in propylene glycol sublingually, in the Gynecological Endocrine Clinic at The Mount Sinai Hospital during the past four years. The series comprises cases of dysmenorrhea, menometrorrhagia, premenstrual tension and menopause syndrome. The patients varied in age from 16 to 61 years. In this report we wish to describe our observations in 23 cases that manifested striking vocal and laryngeal changes as a result of the intramuscular administration of testosterone propionate.The total amount of testosterone propionate which these patients received varied from 225 to 3,000 mg. over periods extending from one to 22 months, given in individual doses of 25 or 50 mg. two or three times weekly.

show abstract

“…Confirmation of the efficacy of the oral route was provided by Byron & Katzen [1941], Kearns [1941], Tager & Shelton [1941]. Salmon, Geist, Gaines & Walter [1941] also believed that this form of androgen therapy would achieve general acceptance, and Lisser, Escamilla & Curtis [1942] stated that oral therapy with methyltestosterone was the simplest, most convenient and possibly the most economical method available.…”

mentioning

confidence: 96%

A Comparison of the Relative Efficacy of Methyltestosterone by the Gastric and Oral Transmucosal Routes

Foss¹

1956

Journal of Endocrinology

View full text Add to dashboard Cite

An attempt has been made to compare the relative efficacy of two methods of medication with methyltestosterone, namely by absorption through the oral mucosa from slowly soluble tablets and by ingestion.The method of comparison adopted was to estimate the extent to which menstruation was postponed after giving 25 mg methyltestosterone twice daily for 30 days from the onset of bleeding. The effectiveness of the two routes of administration was compared in the same individual.The results indicate that buccal absorption is slightly more effective than ingestion.Biskind & Mark [1939] found that, when pellets of testosterone propionate and oestrone were implanted respectively into the spleens of castrate male and female rats, the hormones did not exert their characteristic effect. They did so, however, when the spleens containing the pellets were transplanted subcutaneously and the splenic artery and vein ligated. These findings were taken to mean that the two hormones were inactivated during transport through the liver via the portal circula¬ tion, but the experiment did not exclude the possibility that the spleen

show abstract

The Treatment of Abnormal Uterine Bleeding with Androgens

Cited by 14 publications

References 57 publications

Testosterone Therapy in Women with Gynecological and Sexual Disorders: A Triumph of Clinical Endocrinology from 1938 to 2008

Testosterone Therapy in Women with Gynecological and Sexual Disorders: A Triumph of Clinical Endocrinology from 1938 to 2008

LXXXIX The Effect of Androgen Therapy on the Voice and Vocal Cords of Adult Women

A Comparison of the Relative Efficacy of Methyltestosterone by the Gastric and Oral Transmucosal Routes

Contact Info

Product

Resources

About