[Retracted] The Treatment Combining Antiangiogenesis with Chemoradiotherapy Impinges on the Peripheral Circulation Vascular Endothelial Cells and Therapeutic Effect in the Patients with Locally Advanced Nasopharyngeal Carcinoma

Abstract

This study was implemented for the evaluation on the circulating endothelial cells’ (CECs) clinical significance in the locally advanced nasopharyngeal carcinoma treatment with endostatin-combined chemoradiotherapy. This study enrolled 47 patients with locally advanced nasopharyngeal carcinoma who were hospitalized from May 9, 2012 to March 10, 2013. These patients were split up into the observation group (25 patients) and control group (22 patients). Patients in the observation group received the endostatin combined with induction chemotherapy and subsequently with concurrent chemoradiotherapy with endostatin. Patients in the control group were treated with inductive chemotherapy followed by concurrent chemoradiotherapy. CECs in peripheral blood were conducted separately before or after inductive chemotherapy and additionally in the end of concurrent chemoradiotherapy. The CEC values of the observation group showed significant statistical differences ( p < 0.05 ) before or after different therapies, whereas those data in the control group were not statistically different. And, the mostly importantly, the CEC values in the observation group and control group turned out a statistical difference. The combination of endostatin and chemoradiotherapy significantly reduced parameters of peripheral blood CECs in these patients. According to the CEC parameters’ variety that we observed in the combined therapies, this study demonstrated that the CECs might be a clinical clue to evaluate this antiangiogenic chemoradiotherapy. And the clinical value of CECs will be further determined along with increasing comparative studies and clinical long-term efficacy observation.

Circulating endothelial cells in pathophysiology

“…Recent evidence shows that patients with nasopharyngeal carcinoma undergoing treatment with chemotherapy (docetaxel þ cisplatin) and an angiogenesis inhibitor (endostatin) experience a significant reduction in CEC numbers compared with those receiving chemotherapy alone [56]. This reduction is also evident during everolimus treatment in advanced pancreatic neuroendocrine tumours, supporting everolimus's role in inhibiting angiogenesis [57].…”

Angiogenesis in nasopharyngeal carcinoma: insights, imaging, and therapeutic strategies

“…Endostar significantly enhances radiosensitivity in NPC, reducing the side effects of radiotherapy. Moreover, it can be combined with chemotherapy or chemoradiotherapy to improve the prognosis of patients with metastatic NPC (101,103,104). The effect of endostar is related to the downregulation of VEGF expression (105) and could correct the pathological angiogenesis process to disrupt the hypoxic environment in tumor tissues (106).…”

“…This therapy can be used for the treatment of locally advanced and metastatic NPC ( 98 – 100 ). Recent studies have demonstrated that Endostar, a recombinant human endostatin, is a targeted drug with antiangiogenic and antitumor effects, and when combined with other antitumor therapies, it significantly enhances the overall anticancer effect ( 101 , 102 ). Endostar significantly enhances radiosensitivity in NPC, reducing the side effects of radiotherapy.…”

Retracted: The Treatment Combining Antiangiogenesis with Chemoradiotherapy Impinges on the Peripheral Circulation Vascular Endothelial Cells and Therapeutic Effect in the Patients with Locally Advanced Nasopharyngeal Carcinoma

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Manipulated or compromised peer review …”

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”