The Treatment and Natural Course of Peripheral and Central Vertigo

Strupp, Michael; Dieterich, Marianne; Brandt, Thomas

doi:10.3238/arztebl.2013.0505

Cited by 80 publications

(85 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is postulated that betahistine regulates capillary structures in the stria vascularis of the inner ear, reducing the pressure in the endolymphatic space, and facilitating the reabsorption of endolymphatic fluid. 1,2 High doses of betahistine with a long-term follow-up have shown to increase cochlear perfusion resulting in improved efficacy in the treatment of MD. 28,48,49 Many clinical studies conducted on Indian population have reported and established the standard dose and efficacy of betahistine (discussed in Table 4).…”

Section: Bppvmentioning

confidence: 99%

“…1 It is a basic clinical presentation associated with various diseases with different etiologies such as disorders related to inner ear, brainstem, cerebellum or psychology. 2 Vertigo affects a large number of individuals in general population. The lifetime prevalence of vertigo is ~30% worldwide with an associated comorbidity of 3.2%.…”

Section: Introductionmentioning

confidence: 99%

“…The lifetime prevalence of vertigo is ~30% worldwide with an associated comorbidity of 3.2%. [1][2][3][4] The overall prevalence of vertigo was reported to be 0.71% in an adult rural population from Chandigarh, India. 5 Vertigo presenting as a symptom can have either central or peripheral cause.…”

Section: Introductionmentioning

confidence: 99%

“…These crystals are removed from the utricle, followed by free movement in in the semicircular canals. 2 The reported female-to-male predominance ratio of vestibular dysfunction is about 5:1.…”

Section: Introductionmentioning

confidence: 99%

“…19 The effectiveness and safety of betahistine in different types of peripheral vertigo have been reviewed by various research groups. 1,2 Betahistine is associated with the benefits of histamine, but, it is not associated with the adverse effects observed with histamine such as headaches, flushing, blurred vision, vomiting, or sedation. Moreover, it exhibits no interference with vestibular rehabilitation.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Therapeutic interventions in vertigo management

Kameshwaran

Sarda

2017

Int J Otorhinolaryngol Head Neck Surg

View full text Add to dashboard Cite

<p>Vertigo is a condition associated with a spectrum of symptoms and ~30% of general population experience vertigo in their life time. In spite of being of high clinical importance, the management of vertigo is quite challenging. Though the literature supports the availability of various therapeutic interventions used in vertigo treatment, their effectiveness depends on accurate diagnosis, appropriate use of intervention, and physician’s awareness of the overlap between vestibular, autonomic, and psychological aspects of vestibular pathology. Unfortunately, several drugs act as tranquilizers and impede the process of vestibular compensation. Betahistine, a histamine analogue, is one of the most commonly used anti-vertigo drugs worldwide and has been supported by many clinical trials. There have been several oral communications in international conferences on the efficacy of using betahistine in several clinical vertiginous syndromes. The current review assesses the use of betahistine 48 mg twice daily for three months as an efficient and well-tolerated treatment for vertigo. Additionally, it highlights the low incidence of side effects even at high doses of betahistine and suggests that it may be considered as the first-line of treatment for vestibular dysfunction.</p>

show abstract

Section: Bppvmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%