The Transport and Excretion of Uric Acid in Man. V. A Sex Difference in Urate Metabolism: With a Note on Clinical and Laboratory Findings in Gouty Women*

Wolfson, William Q.; Hunt, Henry D.; Levine, Rachmiel; Guterman, Henry S.; Cohn, Clarence; Rosenberg, Edward F.; Huddlestun, B.; Kadota, Keiichi

doi:10.1210/jcem-9-8-749

Cited by 31 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mean figure for uric acid clearance in the patients is slightly lower than the 7 5 (± 2 4) for gouty men given by Gutman (1964), and the mean figure for male relatives is also slightly lower than his figure for normal men (8 7 + 2 5). The finding of higher clearance figures in female relatives than in male relatives accords with the studies of Wolfson, Hunt, Levine, Guterman, Cohn, Rosenberg, Huddlestun, and Kadota (1949), who found a higher clearance in women than in men.…”

Section: Discussionsupporting

confidence: 89%

Uric acid excretion in the relatives of patients with gout.

Scott¹,

Pollard²

1970

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

This paper describes a study in which uric acid excretion in patients with gout was compared with that of their close relatives. MethodsThe patients all had a diagnosis of primary gout, i.e. they had a characteristic history of acute episodic arthritis with a serum uric acid level above 6 mg./100 ml. and no evident underlying cause for hyperuricaemia. The investigation was carried out before treatment with uratelowering drugs was started. The nature of the study was explained to them and to as many as possible of their adult first-degree relatives, and all the participants were carefully instructed in the details of a low-purine alcoholfree diet (National Institute of Health, Bethesda low purine diet: daily purine content approximately 200 mg.) which they took for 6 days. On the last day they collected a 24-hour urine sample in a provided container which they delivered within a few hours of completion, when a blood sample was also taken. Uric acid and creatinine levels in these samples were estimated by Technicon Auto-Analyzer. 46 patients with 107 adult relatives participated in the investigation. Of these patients, 33 had male relatives and 31 had female relatives, and figures from all these subjects were taken in the analysis relating to serum uric acid levels. Some patients and relatives were excluded from studies involving urine collections, either because creatinine clearance was less than 60 ml./min. (indicating either renal impairment or incomplete urine collection) or, in one instance, because dietary restrictions had clearly been disregarded. The final analysis relating to uric acid excretion therefore applied to 37 patients (36 men and 1 woman) and 96 relatives, of whom 42 were brothers, 40 sisters, 5 mothers, 3 fathers, 3 daughters, and 3 sons; 27 of the gout patients had male relatives and 26 had female relatives. Two of the relatives themselves had gout, but had not taken any treatment for several months.

show abstract

Section: Discussionsupporting

confidence: 89%

Uric acid excretion in the relatives of patients with gout.

Scott¹,

Pollard²

1970

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

show abstract

“…Uric acid, an oxidized purine base, also has considerable free radicalscavenging activity in vitro [18]. Although it has been known for some time that women have lower circulating levels of uric acid than men, probably because of higher renal clearance rates [19], gender differences do not explain the present findings. Further studies are required to determine if the low plasma levels of uric acid found in smokers are the result of a decreased production rate, increased clearance rate or increased utilization of this antioxidant.…”

Section: T-oh T-ac Ratio T-oh T-acmentioning

confidence: 55%

Plasma RRR-α-tocopherol Concentrations Are Lower in Smokers Than in Non-Smokers after Ingestion of a Similar Oral Load of this Antioxidant Vitamin

1997

View full text Add to dashboard Cite

1. Using deuterium-labelled alpha-tocopherol (vitamin E), the plasma kinetics of alpha-tocopherol derived from supplemental RRR-alpha-tocopherol and RRR-alpha-tocopheryl acetate were determined in asymptomatic individuals who smoke and, for comparison, in a group of healthy non-smokers. 2. Venous blood samples were withdrawn 6, 12 and 27 h after the oral administration of a gelatin capsule containing an equimolar mixture of RRR-alpha-tocopheraol and RRR-alpha-tocopheryl acetate. Plasma concentrations of endogenous and administered forms of alpha-tocopherol were determined by a combination of HPLC and GC-MS. 3. Both the free phenol and the acetate ester concentrations of alpha-tocopherol were lower in smokers than in non-smokers: 0.99 versus 1.60 (P < 0.05) and 0.66 versus 1.49 (P < 0.05) mumol/mmol cholesterol for RRR-alpha-tocopherol and RRR-alpha-tocopheryl acetate respectively. The highest concentation of alpha-tocopherol derived from administered RRR-alpha-tocopherol and its acetate ester were observed in plasma at 12 h (compared with 6-h and 27-h measurements) in most subjects. 4. Although the two forms of alpha-tocopherol were administered in equal doses, plasma from smokers contained significantly higher concentrations of RRR-alpha-tocopherol derived from the free phenol form than from the acetate form (0.99 versus 0.66 mumol/mmol cholesterol, P < 0.05, 12 h). Non-smokers did not exhibit preferential uptake of either form of vitamin E. 5. These results suggest that individuals who smoke have either a reduced ability to absorb alpha-tocopherol, particularly when it is presented as the acetate ester, or increased clearance of newly absorbed alpha-tocopherol compared with non-smokers.

show abstract

“…And this of course also means that serum uric acid levels can be lowered to a great degree by dietary means in patients who do not overproduce uric acid endogenously. A geater uric acid clearance in women has previously been noted (Wolfson et al, 1949;Scott and Pollard, 1970), but never on a pUrine-free diet. In Fig.…”

Section: Endogenous Uric Acid Productionmentioning

confidence: 85%

Uric acid lithiasis

Sperling¹,

Vahlensieck²

1981

View full text Add to dashboard Cite

The Transport and Excretion of Uric Acid in Man. V. A Sex Difference in Urate Metabolism: With a Note on Clinical and Laboratory Findings in Gouty Women*

Cited by 31 publications

References 0 publications

Uric acid excretion in the relatives of patients with gout.

Uric acid excretion in the relatives of patients with gout.

Plasma RRR-α-tocopherol Concentrations Are Lower in Smokers Than in Non-Smokers after Ingestion of a Similar Oral Load of this Antioxidant Vitamin

Uric acid lithiasis

Contact Info

Product

Resources

About