The transparent chamber technique for the microscopic study of living blood vessels

Clark, Eliot R.

doi:10.1002/ar.1091200112

Cited by 12 publications

(4 citation statements)

References 17 publications

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“…Finally, these segments disappeared, meaning the capillary bed had been completely replaced by direct arteriolar-venular connections. A possible explanation for this phenomenon might be found in studies showing that increased flow in a microvascular bed can cause capillaries to transition to arterioles [38,39]. Of note, ECs of both arterioles and venules connecting with each other in the fully developed AVM showed no ultra-structural abnormalities [37].…”

Section: Hypotheses Of Avm Formationmentioning

confidence: 99%

Arteriovenous Malformations—Current Understanding of the Pathogenesis with Implications for Treatment

Schimmel

Ali

Tan

et al. 2021

IJMS

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Arteriovenous malformations are a vascular anomaly typically present at birth, characterized by an abnormal connection between an artery and a vein (bypassing the capillaries). These high flow lesions can vary in size and location. Therapeutic approaches are limited, and AVMs can cause significant morbidity and mortality. Here, we describe our current understanding of the pathogenesis of arteriovenous malformations based on preclinical and clinical findings. We discuss past and present accomplishments and challenges in the field and identify research gaps that need to be filled for the successful development of therapeutic strategies in the future.

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Section: Hypotheses Of Avm Formationmentioning

confidence: 99%

Arteriovenous Malformations—Current Understanding of the Pathogenesis with Implications for Treatment

Schimmel

Ali

Tan

et al. 2021

IJMS

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“…In the 1960s and 1970s, the introduction of in vivo preparations and video microscopy (building on earlier use of cine-photography, for example, [31,68,408]) for quantitative study of the microcirculation, enabled direct study of microvascular reactivity at the level of individual tissues [11,12,210,406,407 ]. This further allowed direct observation of network behavior in conjunction with measurements of local intravascular pressures [137,194,195,352,418], vessel diameters [196,197] and red blood cell velocity [38,147,406] (with subsequent calculations of flow).…”

Section: Historical Perspectives 4 Local Control Of Microvascular Permentioning

confidence: 99%

Local Control of Microvascular Perfusion

Hill¹,

Davis²

2012

Colloquium Series on Integrated Systems Physiology: From Molecule to Function

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Physiology is a scientific discipline devoted to understanding the functions of the body. It addresses function at multiple levels, including molecular, cellular, organ, and system. An appreciation of the processes that occur at each level is necessary to understand function in health and the dysfunction associated with disease. Homeostasis and integration are fundamental principles of physiology that account for the relative constancy of organ processes and bodily function even in the face of substantial environmental changes. This constancy results from integrative, cooperative interactions of chemical and electrical signaling processes within and between cells, organs and systems. This eBook series on the broad field of physiology covers the major organ systems from an integrative perspective that addresses the molecular and cellular processes that contribute to homeostasis. Material on pathophysiology is also included throughout the eBooks. The state-of the-art treatises were produced by leading experts in the field of physiology. Each eBook includes stand-alone information and is intended to be of value to students, scientists, and clinicians in the biomedical sciences. Since physiological concepts are an ever-changing work-in-progress, each contributor will have the opportunity to make periodic updates of the covered material.Published titles (for future titles please see the website, AbStrACtLocal control of microvascular perfusion refers to the ability of individual tissues to maintain a relative constancy of hemodynamics in the face of changing perfusion pressure while meeting metabolic demands appropriately. The regulation of local blood flow, or autoregulation, and its underlying mechanisms have been a subject of considerable interest for over 100 years. Particular focus has been placed on the acute interaction of myogenic (pressure-induced) and metabolic (local production of vasodilator metabolites) parameters and how they interact with flow (shear stress)-dependent and conduction-based mechanisms to produce integrated local vascular network responses (for example, as seen during reactive and functional hyperemia). This monograph discusses each of these vasoregulatory phenomena while also considering evidence for their underlying cellular mechanisms. Further, an attempt is made to integrate the information into complex in vivo situations and consider their relevance to pathophysiological situations. vi

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“…The growth of granulation tissue may be accurately observed in vim by means of the transparent-chamber techniques, using rabbit ear chambers (Sandison, 1928 ;Clark, Hitschler, Kirby-Smith, Rex, and Smith, 1931 ;Williams, 1954 ;Ebert, Florey, and Pullinger, 1939) and chambers in the dorsal skin fold of mice . Although qualitative studies have been carried out in detail, particularly by Sandison (1931) and Clark and Clark (1936), and measurements of the rate of growth at various points on the growing surfaces have been made, a growth curve for the entire tissues growing to completion has not been determined. The following experiments, using the rabbit ear chamber technique, have been undertaken to establish growth curves for granulation tissue growing into a rigid space.…”

Section: Granulationmentioning

confidence: 99%

Studies in restorative growth processes in mammalian wound healing

Brenk

1956

Journal of British Surgery

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The transparent chamber technique for the microscopic study of living blood vessels

Cited by 12 publications

References 17 publications

Arteriovenous Malformations—Current Understanding of the Pathogenesis with Implications for Treatment

Arteriovenous Malformations—Current Understanding of the Pathogenesis with Implications for Treatment

Local Control of Microvascular Perfusion

Studies in restorative growth processes in mammalian wound healing

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