The Transmission of Immunity in Experimental Trypanosomiasis (Trypanosoma Cruzi) From Mother Rats to Their Offspring1

Kolodny, Maxwell H.

doi:10.1093/oxfordjournals.aje.a118586

Cited by 4 publications

(4 citation statements)

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“…3) as little transfers were not incorporated in the experiment. That immunity is transferred via the milk rather than by the placenta has been adequately demonstrated (Kolodny, 1939) and, in Exp. 4 with strain 7 where litter transfer was used, F.A.T.…”

Section: Discussionmentioning

confidence: 88%

“…Immunity transferred to young is thought to stem from milk-transmitted immunity. Kolodny (1939) detected milk-transmitted partial protection against T. cruzi in rats up to 25 days after birth.…”

Section: Introductionmentioning

confidence: 92%

“…Immunity transmitted from mother to young has been convincingly described in Trypanosoma lewisi and T. cruzi infections (Culbertson, 1938(Culbertson, , 1939(Culbertson, , 1940Kolodny, 1939) and cannot be ascribed to placental transfer of IgG, although Culbertson (1941) demonstrated a very transient placental transmission of immunity. Immunity transferred to young is thought to stem from milk-transmitted immunity.…”

Section: Introductionmentioning

confidence: 99%

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Trypanosoma cruzi– milk transmission of infection and immunity from mother to young

Miles

1972

Parasitology

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Trypanosomes are consistently present in the milk of lactating mice with primary phase T. cruzi infections (Peru strain). The infection is transmitted to the young, although rarely, mainly due to the difficulty of establishing infection via the oral route. Lactating females which had recovered from the primary phase of T. cruzi infection consistently transferred antibody to their young during suckling. The antibody in the serum of the young and milk of the mother was detectable by the indirect fluorescent antibody technique. In the case of the Peru strain the presence of antibody transferred to the young in this way correlated with very good protection against T. cruzi. Antibody transferred to the young was no longer detectable 6 weeks after birth. The indirect fluorescent antibody technique using bloodform antigen proved specific and highly sensitive throughout, giving prolonged and comparably high titres in mice infected with chronic and acute strains of T. cruzi.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Trypanosoma cruzi– milk transmission of infection and immunity from mother to young

Miles

1972

Parasitology

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“…In murine infection with T. cruzi, maternal-offspring transfer of Ab occurs through lactation (28)(29)(30), but direct kinetic studies of such transfer are lacking. Our report performed with uninfected mice having received purified T. cruzi-specific Ab during gestation and lactation period, showed that Ab levels were reduced by 4 times in offspring at the weaning time (i.e.…”

Section: Vertical Transmission Of T Cruzi-specific Abmentioning

confidence: 99%

Is Antibody-Dependent Enhancement of Trypanosoma cruzi Infection Contributing to Congenital/Neonatal Chagas Disease?

2021

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The newborns of women infected with the parasite Trypanosoma cruzi (the agent of Chagas disease) can be infected either before birth (congenitally), or after birth (as e.g., by vector route). Congenital Chagas disease can induce high levels of neonatal morbidity and mortality. Parasite-infected pregnant women transmit antibodies to their fetus. Antibodies, by opsonizing parasites, can promote phagocytosis and killing of T. cruzi by cells expressing FcγR, on the mandatory condition that such cells are sufficiently activated in an inflammatory context. Antibody-dependent enhancement (ADE) is a mechanism well described in viral infections, by which antibodies enhance entry of infectious agents into host cells by exploiting the phagocytic FcγR pathway. Previously reported Chagas disease studies highlighted a severe reduction of the maternal-fetal/neonatal inflammatory context in parasite-transmitting pregnant women and their congenitally infected newborns. Otherwise, experimental observations brought to light ADE of T. cruzi infection (involving FcγR) in mouse pups displaying maternally transferred antibodies, out of an inflammatory context. Herein, based on such data, we discuss the previously unconsidered possibility of a role of ADE in the trans-placental parasite transmission, and/or the development of severe and mortal clinical forms of congenital/neonatal Chagas disease in newborns of T. cruzi-infected mothers.

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Natural Transmission of Immunity against Trichinella spiralis from Mother Rats to Their Offspring

Culbertson¹

1943

The Journal of Parasitology

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The Transmission of Immunity in Experimental Trypanosomiasis (Trypanosoma Cruzi) From Mother Rats to Their Offspring1

Cited by 4 publications

References 0 publications

Trypanosoma cruzi– milk transmission of infection and immunity from mother to young

Trypanosoma cruzi– milk transmission of infection and immunity from mother to young

Is Antibody-Dependent Enhancement of Trypanosoma cruzi Infection Contributing to Congenital/Neonatal Chagas Disease?

Natural Transmission of Immunity against Trichinella spiralis from Mother Rats to Their Offspring

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