The Transmembrane Protein Kon-tiki Couples to Dgrip to Mediate Myotube Targeting in Drosophila

Schnorrer, Frank; Kalchhauser, Irene; Dickson, Barry J.

doi:10.1016/j.devcel.2007.02.017

Cited by 106 publications

(155 citation statements)

References 52 publications

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“…In Drosophila melanogaster, kon-tiki encodes a transmembrane protein that promotes cell migration in muscle development (47,48). Similar mechanisms have been proposed to generate directed migration and target recognition of myotubes as well as neuronal axon and dendrite growth toward their synaptic partners (49).…”

Section: Discussionmentioning

confidence: 99%

Genetic mapping of male pheromone response in the European corn borer identifies candidate genes regulating neurogenesis

Koutroumpa

Groot

Dekker

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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The sexual pheromone communication system of moths is a model system for studies of the evolution of reproductive isolation. Females emit a blend of volatile components that males detect at a distance. Species differences in female pheromone composition and male response directly reinforce reproductive isolation in nature, because even slight variations in the species-specific pheromone blend are usually rejected by the male. The mechanisms by which a new pheromone signal-response system could evolve are enigmatic, because any deviation from the optimally attractive blend should be selected against. Here we investigate the genetic mechanisms enabling a switch in male response. We used a quantitative trait locus-mapping approach to identify the genetic basis of male response in the two pheromone races of the European corn borer, Ostrinia nubilalis. Male response to a 99:1 vs. a 3:97 ratio of the E and Z isomers of the female pheromone is governed by a single, sex-linked locus. We found that the chromosomal region most tightly linked to this locus contains genes involved in neurogenesis but, in accordance with an earlier study, does not contain the odorant receptors expressed in the male antenna that detect the pheromone. This finding implies that differences in the development of neuronal pathways conveying information from the antenna, not differences in pheromone detection by the odorant receptors, are primarily responsible for the behavioral response differences among the males in this system. Comparison with other moth species reveals a previously unexplored mechanism by which male pheromone response can change in evolution.Ostrinia nubilalis | Z chromosome | pheromone response | sexual communication | QTL analysis

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Section: Discussionmentioning

confidence: 99%

Genetic mapping of male pheromone response in the European corn borer identifies candidate genes regulating neurogenesis

Koutroumpa

Groot

Dekker

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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“…During preparation of this manuscript, Schnorrer and colleagues (Schnorrer et al, 2007), described the phenotypic characterization of loss-of-function mutations in CG10275 (which they named kontiki), and physical and functional interaction of the corresponding protein with Grip. The present work not only corroborates but also extends their findings by demonstrating a requirement for Perd in localizing Grip protein to developing myotendinous junctions, and by proposing a mechanism by which this localization occurs: recognition of tendon cell-expressed PS1 integrin heterodimers by Perd.…”

Section: Discussionmentioning

confidence: 99%

“…Of note, while this manuscript was in preparation, a related paper was published in which equivalent findings were reported for Grip and perd (referred to there as kon-tiki). However, an additional connection between perd (kon-tiki) and integrin function was not established by that work (Schnorrer et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

The transmembrane protein Perdido interacts with Grip and integrins to mediate myotube projection and attachment in theDrosophilaembryo

2007

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The molecular mechanisms underlying muscle guidance and formation of myotendinous junctions are poorly understood both in vertebrates and in Drosophila. We have identified a novel gene that is essential for Drosophila embryonic muscles to form proper projections and stable attachments to epidermal tendon cells. Loss-of-function of this gene -which we named perdido (perd) -results in rounded, unattached muscles. perd is expressed prior to myoblast fusion in a subset of muscle founder cells, and it encodes a conserved single-pass transmembrane cell adhesion protein that contains laminin globular extracellular domains and a small intracellular domain with a C-terminal PDZ-binding consensus sequence. Biochemical experiments revealed that the Perd intracellular domain interacts directly with one of the PDZ domains of the Glutamate receptor interacting protein (Grip), another factor required for formation of proper muscle projections. In addition, Perd is necessary to localize Grip to the plasma membrane of developing myofibers. Using a newly developed, whole-embryo RNA interference assay to analyze genetic interactions, perd was shown to interact not only with Grip but also with multiple edematous wings, which encodes one subunit of the ␣PS1-␤PS integrin expressed in tendon cells. These experiments uncovered a previously unrecognized role for the ␣PS1-␤PS integrin in the formation of muscle projections during early stages of myotendinous junction development. We propose that Perd regulates projection of myotube processes toward and subsequent differentiation of the myotendinous junction by priming formation of a protein complex through its intracellular interaction with Grip and its transient engagement with the tendon cell-expressed lamininbinding ␣PS1-␤PS integrin.

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“…By following individual GFP-labeled myotubes, it is possible to detect the migration path of muscle cells towards their targeted tendon cells (Schnorrer et al, 2007). In this manner, it is possible to distinguish between mutations that affect migration per se from those that affect muscle attachment to tendons.…”

Section: Muscle Targeting and Anchoring To Tendons And Myotendinous Jmentioning

confidence: 99%

Connecting muscles to tendons: tendons and musculoskeletal development in flies and vertebrates

2010

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There was an error published in Development 137, 2807-2817.On p. 2808, StripeB was incorrectly referred to as an epidermal growth factor (Egf)-like, rather than an early growth response (Egr)-like, transcription factor. The corrected sentence appears below.One of the earliest genes that induce tendon progenitor cells within the ectoderm encodes the early growth response (Egr)-like transcription factor StripeB, one of the two isoforms produced by the stripe gene.We apologise to the authors and readers for this mistake. SummaryThe formation of the musculoskeletal system represents an intricate process of tissue assembly involving heterotypic inductive interactions between tendons, muscles and cartilage. An essential component of all musculoskeletal systems is the anchoring of the force-generating muscles to the solid support of the organism: the skeleton in vertebrates and the exoskeleton in invertebrates. Here, we discuss recent findings that illuminate musculoskeletal assembly in the vertebrate embryo, findings that emphasize the reciprocal interactions between the forming tendons, muscle and cartilage tissues. We also compare these events with those of the corresponding system in the Drosophila embryo, highlighting distinct and common pathways that promote efficient locomotion while preserving the form of the organism.

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The Transmembrane Protein Kon-tiki Couples to Dgrip to Mediate Myotube Targeting in Drosophila

Cited by 106 publications

References 52 publications

Genetic mapping of male pheromone response in the European corn borer identifies candidate genes regulating neurogenesis

Genetic mapping of male pheromone response in the European corn borer identifies candidate genes regulating neurogenesis

The transmembrane protein Perdido interacts with Grip and integrins to mediate myotube projection and attachment in theDrosophilaembryo

Connecting muscles to tendons: tendons and musculoskeletal development in flies and vertebrates

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