The transition metal complexes of Fe(II), Ni(II) and Cu(II) derived from phthalazine based ligands: Synthesis, crystal structures and biological activities

Patil, Smita S.; Tadavi, Samina K.; Dikundwar, Amol G.; Bendre, Ratnamala S.

doi:10.1016/j.molstruc.2021.131293

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…These chelators and their synthetic complex derivatives have enormous benefit to acquire varied applications in several fields. They have shown considerable antimalarial, 1 anti-insecticidal, 2 anticancer, 3 anticholinesterase, 4 antitumor, 5,6 anti-tuberculosis, 7 antifungal, [8][9][10][11] antibacterial, 8-11 antihyperglycemic, 12,13 anti-infective, 14 antiradical, 15 antioxidant, [16][17][18] antimicrobial, 19,20 antitrypanosome, 21 antidiabetic, anti-inflammatory, 22,23 antiviral, [23][24][25] antidepressant and nootropic, 26 and gastroprotective activities. 27 Furthermore, They act as enzyme inhibitors, 23,[28][29][30] catalysts in various reactions, [31][32][33] and excellent anticorrosion to protect the metals and alloys as steel.…”

Section: Introductionmentioning

confidence: 99%

Metal complexes of hydrazone–oxime derivative as promising in vitro antimicrobial agents against some fungal and bacterial strains

Hassan

Ebrahium

2022

Applied Organom Chemis

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In this study, Cu2+, Co2+, Ni2+, Mn2+, Zn2+, Fe3+, VO2+, and UO22+ complexes derived from a NNO tridentate chelating hydrazone–oxime, namely, N′‐((2E,3Z)‐3‐(hydroxyimino)butan‐2‐ylidene)benzohydrazide (H2L,1) were prepared. The elemental, thermo‐gravimetric, spectral, molar conductivity, and magnetic measurements were applied to elucidate the compositions and structures of these new compounds. In addition to the density functional theory (DFT), studies were employed to acquire optimal structures and quantum chemical parameters. The analyses indicate that the chelator reacted as a neutral or mononegative tridentate ligand bonded to the metal ions via the enolic/ketonic carbonylic oxygen, protonated/deprotonated oximatic nitrogen, and azomethine nitrogen atoms adopting square planar or distorted octahedral geometry. The structural characterization of hydrazone–oxime and its complexes was supported by DFT calculations according to the DFT‐B3LYP procedure and 6‐311+G(d,p) basis set. The theoretical data revealed that the reactivity of the complexes is greater than the free hydrazone–oxime (H2L,1), and there is a good agreement between the practical and theoretical data. The thermogravimetric investigation shows that the complexes break down in two to four decomposing steps in temperature range extended from 50 to 1000°C. In vitro antimicrobial activity data demonstrated an increase in activity of the hydrazone–oxime (H2L,1), upon chelation, and some metal complexes show enhanced antibacterial and antifungal agents.

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Section: Introductionmentioning

confidence: 99%

Metal complexes of hydrazone–oxime derivative as promising in vitro antimicrobial agents against some fungal and bacterial strains

Hassan

Ebrahium

2022

Applied Organom Chemis

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“…There was no peak visible on the spectrum at m/z = 452, may be attributable to the parent compound's molecular ion [M-H] + . While the peak appeared at 450 which could be attributed to [M -2 ] + [52] .As well as appearance of the peak at m /z = 407, which can be traced to [C19H20ClN2O5S] +.…”

Section: Mass Spectrum Of the Precursor [H2l1]: Positive Esi-ms Formentioning

confidence: 94%

Synthesis, Characterization, and Biological Activity of Mixed ligand Complexes from 8-Hydroxyquinoline and new Ligand for β-Enaminone

Abdulsalam¹,

Numan²

2022

PJMHS

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The synthesized ligand [4-chloro-5-(N-(5,5-dimethyl-3-oxocyclohex-1-en-1-yl)sulfamoyl)-2-((furan-2-ylmethyl)amino)benzoic acid] (H2L1) was identified utilizing Fourier transform infrared spectroscopy (FT-IR), 1 H, 13 C – NMR, (C.H.N), Mass spectra, UV-Vis methods based on spectroscopy. To detect mixed ligand complexes, analytical and spectroscopic approaches such as micro-analysis, conductance, UV-Visible, magnetic susceptibility, and FT-IR spectra were utilized. Its mixed ligand complexes [M(L1)(Q)Cl2] [ where M= Co(II), Ni(II), and Cd(II)] and complexes [Pd(L1)(Q)] and [Pt(L1)(Q)Cl2]; [H2L1] =β-enaminone ligand =L1 and Q= 8-Hydroxyquinoline = L2]. The results showed that the complexes were synthesised utilizing the molar ratio M: L1:L2 (1 :1 :1). The formation of six-coordinate octahedral geometry was proposed for metal complexes Co (II), Ni (II), Cd (II), and Pt (IIII), while the Pd (II) complex was square planar. By using the agar well diffusion method, the ligands and complexes were evaluated for antibacterial activity against Staphylococcus aureus, Escherichia coli. The studies demonstrate that the ligand and its complexes have variable activity against the bacterial types, Some of the complexes had an effect on bacteria, while others had less inhibitory action than the ligand. Also, the produced ligand and its metal complexes have been tested for fungi (Candida albicans );the complexes exhibited suppressing activity against fungi compared to the ligand prepared from them. Keywords: β-enaminones, 5,5-dimethylcyclohexane-1,3-dione , Furosemide, Mixed-ligand complexes, 8-Hydroxyquinoline.

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“…Supramolecular structures are formed through different components interacting with non-covalent interactions such as hydrogen bonding [7] , [8] , [9] , [10] , dipole-dipole interactions, steric repulsions, van der Waals interactions, and London dispersion forces. These non-covalent interactions are important for biological systems as well as contribute to the stability of the crystal structure [11] , [12] , [13] , [14] , [15] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structure, potential drug properties for Coronavirus of Co(II) and Zn(II) 2-chlorobenzoate with 3-cyanopyridine complexes

Öztürkkan

Özdemir

Akbaba

et al. 2022

Journal of Molecular Structure

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The transition metal complexes of Fe(II), Ni(II) and Cu(II) derived from phthalazine based ligands: Synthesis, crystal structures and biological activities

Cited by 5 publications

References 19 publications

Metal complexes of hydrazone–oxime derivative as promising in vitro antimicrobial agents against some fungal and bacterial strains

Metal complexes of hydrazone–oxime derivative as promising in vitro antimicrobial agents against some fungal and bacterial strains

Synthesis, Characterization, and Biological Activity of Mixed ligand Complexes from 8-Hydroxyquinoline and new Ligand for β-Enaminone

Synthesis, crystal structure, potential drug properties for Coronavirus of Co(II) and Zn(II) 2-chlorobenzoate with 3-cyanopyridine complexes

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