Abstract:ski and sno are members of the ski family of nuclear protooncogenes (1-3). Ski was originally identified as the transforming protein of the avian Sloan-Kettering retrovirus (v-Ski) (4, 5). The human cellular homolog c-ski and the closely related snoN were later cloned based on sequence homology to v-ski (1). The amino-terminal region of Ski is highly conserved among Ski family members, including v-Ski (Ͼ95% sequence identity) and SnoN (70% identity), whereas the carboxyl-terminal half of the molecule shows lit… Show more
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