The transcriptome-wide association search for genes and genetic variants which associate with BMI and gestational weight gain in women with type 1 diabetes

Ludwig-Słomczyńska, Agnieszka H.; Seweryn, Michał; Kapusta, Przemysław; Pitera, Ewelina; Mantaj, Urszula; Cyganek, Katarzyna; Gutaj, Paweł; Dobrucka, Łucja; Wender-Ożegowska, Ewa; Małecki, Maciej; Wołkow, Paweł

doi:10.1186/s10020-020-00266-z

Cited by 3 publications

(6 citation statements)

References 111 publications

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“…Previous studies concluded that some genetic variants could be associated with GWG. However, indirectly, as reported by Stuebe [ 24 ], genetic variants associated with pregestational weight have some mediators that affect serum lipids and fat storage and are a cause of diabetes [ 28 , 29 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ]. Accordingly, this process can be supported by genes related to GWG.…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, this process can be supported by genes related to GWG. Considering their effect on pBMI, they could play a role in insulin signaling, glucose homeostasis, mitochondrial metabolism, and inflammatory responses, at least in women with type 1 diabetes mellitus [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…The FADS2 gene codes for a desaturase enzyme that interacts in the process of endogenously converting 18-carbon polyunsaturated fatty acids into very-long-chain fatty acids [ 36 ]. Some single-nucleotide variants in these genes are related to the bioavailability of polyunsaturated fatty acids [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ]. In a sample of 185 Brazilian adult women, the GG FADS2 rs174575 genotype was associated positively with gestational weight gain (coefficient 0.11; p = 0.016; 95% CI 0.10–0.19) [ 28 ].…”

Section: Relevant Sectionsmentioning

confidence: 99%

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Gestational Weight Gain: Is the Role of Genetic Variants a Determinant? A Review

Sámano,

Martínez-Rojano,

Chico-Barba

et al. 2024

IJMS

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Excessive or insufficient gestational weight gain (GWG) leads to diverse adverse maternal and neonatal outcomes. There is evidence that pregestational body mass index (pBMI) plays a role in GWG, but no genetic cause has been identified. In this review, we aim to analyze genotype variants associated with GWG. Results: We identified seven genotype variants that may be involved in GWG regulation that were analyzed in studies carried out in Brazil, Romania, the USA, Turkey, Ukraine, and Canada. Some genetic variants were only associated with GWG in certain races or depending on the pBMI. In women who were obese or overweight before gestation, some genetic variants were associated with GWG. Environmental and genetic factors together showed a greater association with GWG than genetic factors alone; for example, type of diet was observed to have a significant influence. Conclusions: We found little scientific evidence of an association between genotype variants in countries with a high prevalence of women of reproductive age who are overweight and obese, such as in Latin America. GWG may be more dependent on environmental factors than genetic variants. We suggest a deeper study of genetic variants, cytokines, and their possible association with GWG, always with the respective control of potential cofounding factors, such as pBMI, diet, and race.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Relevant Sectionsmentioning

confidence: 99%

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Gestational Weight Gain: Is the Role of Genetic Variants a Determinant? A Review

Sámano,

Martínez-Rojano,

Chico-Barba

et al. 2024

IJMS

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“…ID1 knockout plays a protective role and prevents the development of glucose intolerance and the loss of b-cell gene expression induced by a high-fat diet [ 118 ]. Rs9352745, the expression quantitative trait locus for SH3BGRL2 gene, is associated with gestational weight gain [ 119 ]. This may partly explain the excess weight gain during pregnancy in patients with GDM.…”

Section: Common Features Of Gene Expression In Type 1 Diabetes and Ge...mentioning

confidence: 99%

Overview of Transcriptomic Research on Type 2 Diabetes: Challenges and Perspectives

Tonyan

Nasykhova

Danilova

et al. 2022

Genes

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Type 2 diabetes (T2D) is a common chronic disease whose etiology is known to have a strong genetic component. Standard genetic approaches, although allowing for the detection of a number of gene variants associated with the disease as well as differentially expressed genes, cannot fully explain the hereditary factor in T2D. The explosive growth in the genomic sequencing technologies over the last decades provided an exceptional impetus for transcriptomic studies and new approaches to gene expression measurement, such as RNA-sequencing (RNA-seq) and single-cell technologies. The transcriptomic analysis has the potential to find new biomarkers to identify risk groups for developing T2D and its microvascular and macrovascular complications, which will significantly affect the strategies for early diagnosis, treatment, and preventing the development of complications. In this article, we focused on transcriptomic studies conducted using expression arrays, RNA-seq, and single-cell sequencing to highlight recent findings related to T2D and challenges associated with transcriptome experiments.

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“…Studies have shown that certain allelic variants of some genes are associated with weight increase in people living with type 1 diabetes (T1D) or type 2 diabetes (T2D) [ 6 , 7 ]. In this pilot study, we have investigated the likelihood of weight change over time and how this may vary between people with and without a diagnosis of diabetes when stratified by genotype distribution and allele frequencies of genes previously shown to be associated with weight regulation.…”

Section: Introductionmentioning

confidence: 99%

A study to investigate genetic factors associated with weight gain in people with diabetes: analysis of polymorphisms in four relevant genes

Heald,

Qin,

Loureiro

et al. 2023

Adipocyte

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Background Weight change is often seen in people with diabetes. We investigated the effects of genes associated with weight change/glucose handling/insulin-signalling. Materials/methods DNA from diabetes individuals and non-diabetes individuals, plus clinical data, were available from the DARE study ( n = 379 individuals: T1D n = 111; T2D n = 222; controls n = 46). Weight gain was assessed by temporal change of Body Mass Index (BMI). Genotyping was performed for CAV1 rs926198, LEPR rs1137101, BDNF rs6265 and FTO rs9939609. Results No differences in genotype distributions were observed for the four SNPs in all groups un-stratified by weight gain. Following stratification differences in genotype distribution were observed. For those BMI relatively stable; controls showed a difference in genotype distributions versus T1D ( CAV1 rs926198, LEPR rs1137101). In T2D vs controls, significant differences were observed in genotype distribution for all four genes. For BMI increase, the only difference by category was LEPR rs1137101 (bothT1D/T2D vs controls). In BMI-stable groups, CAV1 rs926198, T1D individuals showed lower T allele frequency ( p =0.004) vs non-diabetes and for LEPR rs1137101 a higher G allele frequency versus controls ( p =0.002). For T2D, CAV1 rs926198, T allele frequency was lower in T2D than controls ( p =0.005). For LEPR rs1137101, the G allele frequency was higher than in controls ( p =0.004). In those with BMI increase, LEPR rs1137101 T1D individuals had higher G allele frequency versus controls ( p =0.002) as did T2D vs controls ( p =0.03). Conclusion Differences in allele frequency were seen between diabetes individuals and non-diabetes diagnosed at baseline in relation to the likelihood of BMI increase of >10%. It is established that the G allele of LEPR rs1137101 is associated with weight gain/obesity. However, this is the first report of CAV1 rs926198 polymorphism being associated with weight stability/gain in diabetes.

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The transcriptome-wide association search for genes and genetic variants which associate with BMI and gestational weight gain in women with type 1 diabetes

Cited by 3 publications

References 111 publications

Gestational Weight Gain: Is the Role of Genetic Variants a Determinant? A Review

Gestational Weight Gain: Is the Role of Genetic Variants a Determinant? A Review

Overview of Transcriptomic Research on Type 2 Diabetes: Challenges and Perspectives

A study to investigate genetic factors associated with weight gain in people with diabetes: analysis of polymorphisms in four relevant genes

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