The transcription factors Creb1 and CEBPB regulate Sox9 promoter activity in TM4 Sertoli cells

Diawara, Mariama; Arsenault, A.; Charette, Sj; Martin, Luc J.

doi:10.1016/j.gene.2023.147477

Cited by 3 publications

(2 citation statements)

References 50 publications

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“…EGR1 has been implicated in cell growth, differentiation, and apoptosis [43][44][45], whereas PRKACA is involved in multiple signaling pathways, including cell growth and differentiation [46,47]. PITX2 participates in developmental and oncogenic regulations [48][49][50], and CREB1 is a transcription factor involved in various cellular processes, such as cell proliferation, differentiation, and survival [51][52][53]. Lastly, JUND, a member of the AP-1 transcription factor family, regulates cell growth, differentiation, and apoptosis [54][55][56].…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Profiling of Lactotroph Pituitary Neuroendocrine Tumors via RNA Sequencing and Ingenuity Pathway Analysis

Hattori,

Tahara,

Ozawa

et al. 2024

Neuroendocrinology

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Introduction: Lactotroph pituitary neuroendocrine tumors (PitNETs) are common pituitary tumors, but their underlying molecular mechanisms remain unclear. This study aimed to investigate the transcriptomic landscape of lactotroph PitNETs and identify potential molecular mechanisms and therapeutic targets through RNA sequencing and ingenuity pathway analysis (IPA). Methods: Lactotroph PitNET tissues from five surgical cases without dopamine agonist treatment underwent RNA sequencing. Normal pituitary tissues from three patients served as controls. Differentially expressed genes (DEGs) were identified, and the functional pathways and gene networks were explored by IPA. Results: Transcriptome analysis revealed that lactotroph PitNETs had gene expression patterns that were distinct from normal pituitary tissues. We identified 1,172 upregulated DEGs, including nine long intergenic noncoding RNAs (lincRNAs) belonging to the top 30 DEGs. IPA of the upregulated DEGs showed that the estrogen receptor signaling, oxidative phosphorylation signaling, and EIF signaling were activated. In gene network analysis, key upstream regulators, such as EGR1, PRKACA, PITX2, CREB1, and JUND, may play critical roles in lactotroph PitNETs. Conclusion: This study provides a comprehensive transcriptomic profile of lactotroph PitNETs and highlights the potential involvement of lincRNAs and specific signaling pathways in tumor pathogenesis. The identified upstream regulators may be potential therapeutic targets for future investigations.

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Section: Discussionmentioning

confidence: 99%

Transcriptomic Profiling of Lactotroph Pituitary Neuroendocrine Tumors via RNA Sequencing and Ingenuity Pathway Analysis

Hattori,

Tahara,

Ozawa

et al. 2024

Neuroendocrinology

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“…In postnatal Sertoli cells, CCAAT enhancer binding protein beta activates SOX9 expression. cAMP-responsive element binding protein 1 is recruited to the proximal promoter region of SOX9 through the cAMP/protein kinase A signaling pathway, leading to CREB1 phosphorylation, which promotes SOX9 expression ( 128 ).…”

Section: Abnormalities In the Molecular Regulation Of Sertoli Cell Li...mentioning

confidence: 99%

Unveiling the roles of Sertoli cells lineage differentiation in reproductive development and disorders: a review

Gao,

Wang,

Long

et al. 2024

Front. Endocrinol.

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In mammals, gonadal somatic cell lineage differentiation determines the development of the bipotential gonad into either the ovary or testis. Sertoli cells, the only somatic cells in the spermatogenic tubules, support spermatogenesis during gonadal development. During embryonic Sertoli cell lineage differentiation, relevant genes, including WT1, GATA4, SRY, SOX9, AMH, PTGDS, SF1, and DMRT1, are expressed at specific times and in specific locations to ensure the correct differentiation of the embryo toward the male phenotype. The dysregulated development of Sertoli cells leads to gonadal malformations and male fertility disorders. Nevertheless, the molecular pathways underlying the embryonic origin of Sertoli cells remain elusive. By reviewing recent advances in research on embryonic Sertoli cell genesis and its key regulators, this review provides novel insights into sex determination in male mammals as well as the molecular mechanisms underlying the genealogical differentiation of Sertoli cells in the male reproductive ridge.

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The transcription factors NR5A1 and JUNB cooperate to activate the Axl promoter in mouse Sertoli cell lines

Diawara,

Martin

2024

Mol Biol Rep

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The transcription factors Creb1 and CEBPB regulate Sox9 promoter activity in TM4 Sertoli cells

Cited by 3 publications

References 50 publications

Transcriptomic Profiling of Lactotroph Pituitary Neuroendocrine Tumors via RNA Sequencing and Ingenuity Pathway Analysis

Transcriptomic Profiling of Lactotroph Pituitary Neuroendocrine Tumors via RNA Sequencing and Ingenuity Pathway Analysis

Unveiling the roles of Sertoli cells lineage differentiation in reproductive development and disorders: a review

The transcription factors NR5A1 and JUNB cooperate to activate the Axl promoter in mouse Sertoli cell lines

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