2013
DOI: 10.1074/jbc.m112.413377
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The Transcription Factor Protein Sox11 Enhances Early Osteoblast Differentiation by Facilitating Proliferation and the Survival of Mesenchymal and Osteoblast Progenitors

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Cited by 50 publications
(49 citation statements)
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References 32 publications
(12 reference statements)
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“…The zebrafish genome contains two orthologs of human SOX11, sox11a and sox11b, which are expressed in all cells until gastrulation and later become restricted to the developing CNS 15,16 . We knocked down zebrafish sox11a and sox11b (both single-exon genes) using translation-blocking morpholino oligonucleotides (MOs) (sox11a-MO, sox11b-MO and sox11a/b-MO), as previously described 17 ( Supplementary Fig. 5a).…”
Section: Wes Of Css Patientsmentioning
confidence: 99%
“…The zebrafish genome contains two orthologs of human SOX11, sox11a and sox11b, which are expressed in all cells until gastrulation and later become restricted to the developing CNS 15,16 . We knocked down zebrafish sox11a and sox11b (both single-exon genes) using translation-blocking morpholino oligonucleotides (MOs) (sox11a-MO, sox11b-MO and sox11a/b-MO), as previously described 17 ( Supplementary Fig. 5a).…”
Section: Wes Of Css Patientsmentioning
confidence: 99%
“…Among the 24 genes in the aberrant 2p region was the triplicated SOX11 , encoding a SoxC group high mobility group (HMG) box‐containing transcription factor. SOX11 has major roles in embryonic and adult neurogenesis, craniofacial osteogenesis, ocular morphogenesis, and cardiac development, all specifically disrupted in CHARGE [Hargrave et al, ; Sock et al, ; Jankowski et al, ; Potzner et al, ; Gadi et al, ; Wang et al, ; Paul et al, ; Pillai‐Kastoori et al, ]. Sanger sequencing and RQ‐PCR on our patient and on 28 patients with CHARGE phenotypes, negative chromosomal microarray, and negative CHD7 mutation testing showed no SOX11 mutations or duplications.…”
Section: Resultsmentioning
confidence: 70%
“…SOX4 overexpression was shown to promote cell cycle arrest and apoptosis of HCT116 colon carcinoma cells (47). Morpholino-targeted disruption of Sox11 in zebrafish also identified that Sox11 plays a crucial role in enhancing osteoblast differentiation by facilitating the proliferation of mesenchymal and osteoblast progenitor cells (45). BrdU incorporation assays have shown a significant reduction in cell proliferation in the neural tube, the branchial arches, and somites of Sox4/Sox11 double mutant mice (48).…”
Section: Discussionmentioning
confidence: 99%