Abstract:Dopamine (DA) is necessary for motor function, motivation, working memory, and reward. However, how DA regulates reward-related learning and memorythrough the gene expression is not fully understood. Neuronal Per Arnt Sim domain protein 4 (Npas4), a brain-specific basic helix-loop-helix transcription factor, plays a role in synaptic plasticity by regulating the expression of activity-dependent genes,such as BDNF.Although Npas4 required forcontextual fear memory formation in mice, the role of Npas4 in reward-re… Show more
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