The Transcription Factor GATA3 Is Critical for the Development of All IL-7Rα-Expressing Innate Lymphoid Cells

Yagi, Ryoji; Zhong, Chao; Northrup, Daniel; Yu, Fang; Bouladoux, Nicolas; Spencer, Sean P.; Hu, Gangqing; Barron, Luke; Sharma, Suveena; Nakayama, Toshinori; Belkaid, Yasmine; Zhao, Keji; Zhu, Jinfang

doi:10.1016/j.immuni.2014.01.012

Cited by 347 publications

(459 citation statements)

References 53 publications

(84 reference statements)

Supporting

Mentioning

415

Contrasting

Unclassified

Order By: Relevance

“…6C). It has been shown that GATA3 suppresses the expression of a death receptor tnfrsf21 and a cell cycle inhibitor cdkn2b in ILC2s (30). As expected, expression of these genes was reduced in Spred1…”

Section: Spred1 Regulates Gata3 Stabilization In Ilc2ssupporting

confidence: 65%

“…It has been reported that GATA3 plays a crucial role in the type 2 cytokine expression in ILC2s and in expansion and survival of ILC2s (9,30). Because the GATA3 protein is stabilized via the activated ERK signaling pathway in Th2 cells (31), we examined the effect of Spred1 deficiency on the expression levels of GATA3 in ILC2s.…”

Section: Spred1 Regulates Gata3 Stabilization In Ilc2smentioning

confidence: 99%

See 1 more Smart Citation

Spred1, a Suppressor of the Ras–ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells

Suzuki

Morita

Hirata

et al. 2015

The Journal of Immunology

View full text Add to dashboard Cite

Cytokines from group 2 innate lymphoid cells (ILC2s) have been implicated in acute allergic responses, such as papain-induced lung inflammation. However, the means of homeostatic regulation of ILC2s have not been established. In this study, we demonstrated that Spred1, a negative regulator of the Ras–ERK pathway, plays an important role in the proliferation and apoptosis of ILC2s and in cytokine secretion from ILC2s. Intranasal administration of papain stimulated IL-5 and IL-13 production in the lung, which was enhanced when Spred1 was deleted. In vitro, Spred1−/− ILC2s proliferated faster than wild type ILC2s did and produced higher levels of cytokines in response to IL-33. On the contrary, a MEK inhibitor suppressed ILC2 proliferation and cytokine production. Spred1 deficiency resulted in stabilization of GATA3, which has been shown to play essential roles in the maintenance and cytokine production of ILC2. These data suggest that Spred1 negatively regulates ILC2 development and functions through the suppression of the Ras–ERK pathway.

show abstract

Section: Spred1 Regulates Gata3 Stabilization In Ilc2ssupporting

confidence: 65%

Section: Spred1 Regulates Gata3 Stabilization In Ilc2smentioning

confidence: 99%

Spred1, a Suppressor of the Ras–ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells

Suzuki

Morita

Hirata

et al. 2015

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…1). Progressive commitment to the ILC lineage is also dependent, to varying degrees, on a multitude of transcription factors including GATA‐3, TOX, TCF‐1 and NFIL316, 17, 18, 19, 20, 21 (and reviewed in detail in references 10 and 22). …”

Section: Group 3 Innate Lymphoid Cell Developmentmentioning

confidence: 99%

Functional and phenotypic heterogeneity of group 3 innate lymphoid cells

2017

View full text Add to dashboard Cite

SummaryGroup 3 innate lymphoid cells (ILC3), defined by expression of the transcription factor retinoid‐related orphan receptor γt, play key roles in the regulation of inflammation and immunity in the gastrointestinal tract and associated lymphoid tissues. ILC3 consist largely of two major subsets, NCR + ILC3 and LTi‐like ILC3, but also demonstrate significant plasticity and heterogeneity. Recent advances have begun to dissect the relationship between ILC3 subsets and to define distinct functional states within the intestinal tissue microenvironment. In this review we discuss the ever‐expanding roles of ILC3 in the context of intestinal homeostasis, infection and inflammation – with a focus on comparing and contrasting the relative contributions of ILC3 subsets.

show abstract

“…Similar to the case for T cells, GATA-3 is required at a very early progenitor stage as in gata3-deficient mice, the development of all IL-7-dependent ILC populations is compromised (Serafini et al 2014;Yagi et al 2014). GATA-3 is also required for the maintenance and function of mature mouse (Hoyler et al 2012) and human (Mjosberg et al 2012) ILC2, but not other ILC populations, after development.…”

Section: Development and Ontogeny Of Ilc2mentioning

confidence: 80%

Innate Lymphoid Cells in Type 2 Immune Responses

Mirchandani

Salmond

2014

Arch. Immunol. Ther. Exp.

View full text Add to dashboard Cite

In recent years, several distinct innate lymphoid cell populations (ILC) have been characterized in mice and humans. Group 2 ILC function as a rapid responder population in type 2 immune responses. Thus, a wealth of data has implicated an important role for ILC2 in immunity to parasitic infection and in immune pathology in inflammatory and allergic responses. In this review, we describe recent progress in our understanding of the development and ontogeny of ILC2 populations and the mechanisms by which these cells function in a variety of infection and disease settings. Finally, we emphasize recent findings indicating functional interactions between these innate cells and their adaptive CD4 ? Th2 cell counterparts.

show abstract

The Transcription Factor GATA3 Is Critical for the Development of All IL-7Rα-Expressing Innate Lymphoid Cells

Cited by 347 publications

References 53 publications

Spred1, a Suppressor of the Ras–ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells

Spred1, a Suppressor of the Ras–ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells

Functional and phenotypic heterogeneity of group 3 innate lymphoid cells

Innate Lymphoid Cells in Type 2 Immune Responses

Contact Info

Product

Resources

About