The transcription factor carbohydrate-response element-binding protein (ChREBP): A possible link between metabolic disease and cancer

Iizuka, Katsumi

doi:10.1016/j.bbadis.2016.11.029

Cited by 61 publications

(82 citation statements)

References 132 publications

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“…Several Drosophila MondoA-MLX target genes have human orthologs that contain polymorphisms associated with high levels of circulating triglycerides and coronary artery disease [81]. In addition MLXIPL-MLX regulates gene expression linked to glucose and lipid metabolism, and genetic studies further implicate this heterodimer in metabolic disease and cancer (for review see [83]).…”

Section: Mgamentioning

confidence: 99%

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

et al. 2018

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Transcription factor networks have evolved in order to control, coordinate, and separate, the functions of distinct network modules spatially and temporally. In this review we focus on the MYC network (also known as the MAX-MLX Network), a highly conserved super-family of related basic-helix-loop-helix-zipper (bHLHZ) proteins that functions to integrate extracellular and intracellular signals and modulate global gene expression. Importantly the MYC network has been shown to be deeply involved in a broad spectrum of human and other animal cancers. Here we summarize molecular and biological properties of the network modules with emphasis on functional interactions among network members. We suggest that these network interactions serve to modulate growth and metabolism at the transcriptional level in order to balance nutrient demand with supply, to maintain growth homeostasis, and to influence cell fate. Moreover, oncogenic activation of MYC and/or loss of a MYC antagonist, results in an imbalance in the activity of the network as a whole, leading to tumor initiation, progression and maintenance.

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Section: Mgamentioning

confidence: 99%

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

et al. 2018

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“…The least potent isoform, ChREBPα, is inhibited under conditions of low glucose [ 59 ]; however, upon activation by intracellular carbohydrate metabolites, ChREBPα induces the transcription of a more potent isoform, ChREBPβ, from an alternative promotor [ 60 ]. Thus, the ChREBPα/β mechanism senses intracellular carbohydrate signals and regulates the expression of metabolic gene programs in response to increased carbohydrate availability [ 61 ].…”

Section: What Are the Mechanisms Linking Fructose To Nafld?mentioning

confidence: 99%

Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease

Horst¹,

2017

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Increased fructose consumption has been suggested to contribute to non-alcoholic fatty liver disease (NAFLD), dyslipidemia, and insulin resistance, but a causal role of fructose in these metabolic diseases remains debated. Mechanistically, hepatic fructose metabolism yields precursors that can be used for gluconeogenesis and de novo lipogenesis (DNL). Fructose-derived precursors also act as nutritional regulators of the transcription factors, including ChREBP and SREBP1c, that regulate the expression of hepatic gluconeogenesis and DNL genes. In support of these mechanisms, fructose intake increases hepatic gluconeogenesis and DNL and raises plasma glucose and triglyceride levels in humans. However, epidemiological and fructose-intervention studies have had inconclusive results with respect to liver fat, and there is currently no good human evidence that fructose, when consumed in isocaloric amounts, causes more liver fat accumulation than other energy-dense nutrients. In this review, we aim to provide an overview of the seemingly contradicting literature on fructose and NAFLD. We outline fructose physiology, the mechanisms that link fructose to NAFLD, and the available evidence from human studies. From this framework, we conclude that the cellular mechanisms underlying hepatic fructose metabolism will likely reveal novel targets for the treatment of NAFLD, dyslipidemia, and hepatic insulin resistance. Finally, fructose-containing sugars are a major source of excess calories, suggesting that a reduction of their intake has potential for the prevention of NAFLD and other obesity-related diseases.

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“…The differences between the results of PFMA and PGMA are probably related to the higher hydrolysis rate and fructose release rate to the culture medium. Nutrients such as glucose, fructose and fatty acids are reported to stimulate both expression and activation of the key transcription factor, which is reported to increase cell proliferation . Therefore, neither the hydrogels nor their degradation products in culture medium are cytotoxic, making PFMA and PGMA hydrogels suitable materials for biomedical applications.…”

Section: Resultsmentioning

confidence: 99%

“…Nutrients such as glucose, fructose and fatty acids are reported to stimulate both expression and activation of the key transcription factor, which is reported to increase cell proliferation. [63][64][65] Therefore, neither the hydrogels nor their degradation products in culture medium are cytotoxic, making PFMA and PGMA hydrogels suitable materials for biomedical applications. wall thickness, swelling behavior and mechanical resistance.…”

Section: Differential Scanning Calorimetrymentioning

confidence: 99%

Macroporous hydrogels based on carbohydrates monomethacrylates and dimethacrylates: singular properties from carbohydrate‐based crosslinkers

Perin

Fonseca

Felisberti

2019

J of Chemical Tech & Biotech

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BACKGROUND Readily available feedstock and biocompatibility make carbohydrate‐based hydrogels promising materials for biomedical applications. However, carbohydrate‐based crosslinkers are rather underexplored when compared with crosslinkers derived from fossil resources. In this study, novel fully bio‐based hydrogels derived from enzymatically produced d‐fructose and d‐glucose methacrylate monomers were synthesized with different amounts of d‐fructose dimethacrylate crosslinker. RESULTS The use of a carbohydrate‐based crosslinker endows hydrogels with high swelling coefficients, up to 2400%, and superior mechanical resistance (compressive modulus up to 9.5 kPa with a maximum stress up to 50 kPa) compared with conventional crosslinkers based on fossil resources. Hydrogels shape and crosslinking density influences hydrogel morphology, swelling behavior and mechanical resistance. Moreover, hydrogels presented cell viability, biodegradability and hydrolysis‐resistance over a wide range of pH. CONCLUSION The use of a highly hydrophilic crosslinker based on carbohydrate for hydrogels synthesis enables the use of high crosslinker concentration, which improves mechanical properties, however with minor loss of the water swelling capacity, compared with conventional fossil‐based crosslinkers. This is an important advantage over conventional crosslinkers based on fossil resources. Moreover, slab hydrogels hold higher stress under compression–decompression cycles, and present higher resistance to hydrolysis in basic medium due to the thicker pore walls than cylindrical ones. © 2019 Society of Chemical Industry

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The transcription factor carbohydrate-response element-binding protein (ChREBP): A possible link between metabolic disease and cancer

Cited by 61 publications

References 132 publications

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease

Macroporous hydrogels based on carbohydrates monomethacrylates and dimethacrylates: singular properties from carbohydrate‐based crosslinkers

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