The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer’s Disease Mouse Model

Buendía, Débora; Guncay, Tatiana; Oyanedel, Macarena; Lemus, Makarena; Weinstein, Alejandro; Ardiles, Álvaro O.; Marcos, José Luis; Fernandes, Adriana Barrinha; Zângaro, Renato Amaro; Muñoz, Pablo

doi:10.3390/brainsci12101272

Cited by 11 publications

(21 citation statements)

References 68 publications

(76 reference statements)

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“…Reportedly, PBMT has been found to stimulate BDNF production which is a critical regulator of synaptic plasticity that promotes synaptic transmission and synaptogenesis [ 35 ]. PBMT has also been shown to improve synaptic plasticity in Alzheimer’s disease [ 81 ]. The ability of PBMT to stimulate BDNF may explain its effects on reducing harmful neuroplasticity in tinnitus, however further research is needed to confirm this.…”

Section: Discussionmentioning

confidence: 99%

Photobiomodulation therapy in improvement of harmful neural plasticity in sodium salicylate-induced tinnitus

Montazeri,

Farhadi,

Majdabadi

et al. 2024

PLoS ONE

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Tinnitus is a common annoying symptom without effective and accepted treatment. In this controlled experimental study, photobiomodulation therapy (PBMT), which uses light to modulate and repair target tissue, was used to treat sodium salicylate (SS)-induced tinnitus in a rat animal model. Here, PBMT was performed simultaneously on the peripheral and central regions involved in tinnitus. The results were evaluated using objective tests including gap pre-pulse inhibition of acoustic startle (GPIAS), auditory brainstem response (ABR) and immunohistochemistry (IHC). Harmful neural plasticity induced by tinnitus was detected by doublecortin (DCX) protein expression, a known marker of neural plasticity. PBMT parameters were 808 nm wavelength, 165 mW/cm2 power density, and 99 J/cm2 energy density. In the tinnitus group, the mean gap in noise (GIN) value of GPIAS test was significantly decreased indicated the occurrence of an additional perceived sound like tinnitus and also the mean ABR threshold and brainstem transmission time (BTT) were significantly increased. In addition, a significant increase in DCX expression in the dorsal cochlear nucleus (DCN), dentate gyrus (DG) and the parafloccular lobe (PFL) of cerebellum was observed in the tinnitus group. In PBMT group, a significant increase in the GIN value, a significant decrease in the ABR threshold and BTT, and also significant reduction of DCX expression in the DG were observed. Based on our findings, PBMT has the potential to be used in the management of SS-induced tinnitus.

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Section: Discussionmentioning

confidence: 99%

Photobiomodulation therapy in improvement of harmful neural plasticity in sodium salicylate-induced tinnitus

Montazeri,

Farhadi,

Majdabadi

et al. 2024

PLoS ONE

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“…t-PBM was best with LEDs as a light source, but the effect was insignificant. Although it is debated whether lasers are superior to LEDs, there is evidence that LEDs are comparable to lasers ( 15 ) and are safer and less costly ( 79 , 80 ). t-PBMs are typically available at wavelengths in the 600–1,164 nm region, and wavelengths in this range can stimulate CCO activity more ( 81 ).…”

Section: Discussionmentioning

confidence: 99%

Photobiomodulation improves depression symptoms: a systematic review and meta-analysis of randomized controlled trials

Ji,

Yan,

Ding

et al. 2024

Front. Psychiatry

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BackgroundDepression is a common mental illness that is widely recognized by its lack of pleasure, fatigue, low mood, and, in severe cases, even suicidal tendencies. Photobiomodulation (PBM) is a non-invasive neuromodulation technique that could treat patients with mood disorders such as depression.MethodsA systematic search of ten databases, including randomized controlled trials (RCTs) for depression, was conducted from the time of library construction to September 25, 2023. The primary outcome was depression. The secondary outcome was sleep. Meta-analysis was performed using RevMan (version 5.4) and Stata (version 14.0). Subgroup analyses were performed to identify sources of heterogeneity. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE).ResultsThree thousand two hundred and sixty-five studies were retrieved from the database and screened for inclusion in eleven trials. The forest plot results demonstrated that PBM alleviated depression (SMD = −0.55, 95% CI [−0.75, −0.35], I2 = 46%). But it is not statistically significant for patients’ sleep outcomes (SMD = −0.82, 95% CI [−2.41, 0.77], I2 = 0%, p > 0.05). Subgroup analysis showed that s-PBM was superior to t-PBM in relieving symptoms of depression. The best improvement for t-PBM was achieved using a wavelength of 823 nm, fluence of 10–100 J/cm2, irradiance of 50–100 mW/cm2, irradiance time of 30 min, treatment frequency < 3/week, and number of treatments >15 times. The best improvement for s-PBM was achieved using a wavelength of 808 nm, fluence ≤1 J/cm2, irradiance of 50–100 mW/cm2, irradiance time ≤ 5 min, treatment frequency ≥ 3/week, number of treatments >15 times. All results had evidence quality that was either moderate or very low, and there was no bias in publication.ConclusionWe conclude that PBM is effective in reducing depression symptoms in patients. However, the current number of studies is small, and further studies are needed to extend the current analysis results.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, CRD42023444677.

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“…PBM may influence synaptic plasticity, which is the ability of synapses to strengthen or weaken over time, affecting neuronal signaling. By promoting synaptic plasticity, PBM could enhance cognitive recovery and functional improvements in TBI patients [ 67 , 68 ].…”

Section: Additional Relevant Systemic and Secondary Pbm Mechanismsmentioning

confidence: 99%

“…Additional Systemic Mechanisms PBM enhances cellular energy production, improves blood flow, modulates synaptic plasticity, and reduces ferroptosis [65][66][67][68][69][70].…”

Section: Axonal Degenerationmentioning

confidence: 99%

Traumatic Brain Injury Recovery with Photobiomodulation: Cellular Mechanisms, Clinical Evidence, and Future Potential

Lim

2024

Cells

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Traumatic Brain Injury (TBI) remains a significant global health challenge, lacking effective pharmacological treatments. This shortcoming is attributed to TBI’s heterogeneous and complex pathophysiology, which includes axonal damage, mitochondrial dysfunction, oxidative stress, and persistent neuroinflammation. The objective of this study is to analyze transcranial photobiomodulation (PBM), which employs specific red to near-infrared light wavelengths to modulate brain functions, as a promising therapy to address TBI’s complex pathophysiology in a single intervention. This study reviews the feasibility of this therapy, firstly by synthesizing PBM’s cellular mechanisms with each identified TBI’s pathophysiological aspect. The outcomes in human clinical studies are then reviewed. The findings support PBM’s potential for treating TBI, notwithstanding variations in parameters such as wavelength, power density, dose, light source positioning, and pulse frequencies. Emerging data indicate that each of these parameters plays a role in the outcomes. Additionally, new research into PBM’s effects on the electrical properties and polymerization dynamics of neuronal microstructures, like microtubules and tubulins, provides insights for future parameter optimization. In summary, transcranial PBM represents a multifaceted therapeutic intervention for TBI with vast potential which may be fulfilled by optimizing the parameters. Future research should investigate optimizing these parameters, which is possible by incorporating artificial intelligence.

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The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer’s Disease Mouse Model

Cited by 11 publications

References 68 publications

Photobiomodulation therapy in improvement of harmful neural plasticity in sodium salicylate-induced tinnitus

Photobiomodulation therapy in improvement of harmful neural plasticity in sodium salicylate-induced tinnitus

Photobiomodulation improves depression symptoms: a systematic review and meta-analysis of randomized controlled trials

Traumatic Brain Injury Recovery with Photobiomodulation: Cellular Mechanisms, Clinical Evidence, and Future Potential

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