The trans‐metastasis hepatectomy (through metastases previously ablated with radiofrequency): Results of a 13‐case study of colorectal cancer

Élias, Dominique; Manganas, D.; Benizri, Emmanuel; Dufour, Fanny; Menegon, Paola; Harroudi, T. El; Baère, Thierry De

doi:10.1002/jso.20391

Cited by 21 publications

(14 citation statements)

References 26 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Their safety and efficacy have already been proven (16,18) and the location of LM is no longer a limit to RFA. Fourth, due to the high number of RF ablations in the remaining part of the liver, maximum sparing of normal parenchyma is critical :…”

Section: Discussionmentioning

confidence: 99%

“…The surgeon constantly referred to drawing indicating the sites and sizes of LM produced following ultrasound detection before RFA. Simple RFA sessions were performed (14), but when necessary, the central bile ducts were also cooled to protect them from heat (a technique we described in 2001) (15,16), or a trans-RF hepatectomy was performed after RF destruction of one or several LM located along a suitable transection line, in order to spare as much normal parenchyma as possible (a technique we described in 2002) (17,18). Patients underwent a postoperative CTscan before being discharged from hospital.…”

Section: Surgical Proceduresmentioning

confidence: 99%

See 1 more Smart Citation

Combined liver surgery and RFA for patients with gastroenteropancreatic endocrine tumors presenting with more than 15 metastases to the liver

Élias

Goèré

Leroux

et al. 2009

European Journal of Surgical Oncology (EJSO)

View full text Add to dashboard Cite

Please cite this article as: Elias D., Goéré D., Leroux G., Dromain C., Leboulleux S., de Baere T., Ducreux M., Baudin E. Combined liver surgery and RFA for patients with gastroenteropancreatic endocrine tumors presenting with more than 15 metastases to the liver., European Journal of Surgical Oncology (2009Oncology ( ), doi: 10.1016Oncology ( /j.ejso.2009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Accepted ManuscriptTitle: Combined liver surgery and RFA for patients with gastroenteropancreatic endocrine tumors presenting with more than 15 metastases to the liver.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Surgical Proceduresmentioning

confidence: 99%

Combined liver surgery and RFA for patients with gastroenteropancreatic endocrine tumors presenting with more than 15 metastases to the liver

Élias

Goèré

Leroux

et al. 2009

European Journal of Surgical Oncology (EJSO)

View full text Add to dashboard Cite

show abstract

“…Ouellet et al [37] reported no radiological evidence of disease at 6 months in four patients subjected to TMH. Elias et al [39] reported no local recurrence in 13 patients with bilateral unresectable CRC LM treated with TMH with hepatic inflow occlusion, after a mean follow-up of 19.4 months.…”

Section: Discussion Radiofrequency Ablation (Rfa)mentioning

confidence: 98%

“…RFA can artificially increase the surgical margin thus allowing TMH [23,[37][38][39]. The technique is applicable to tumors close to a vessel or bile duct when the resection margin is less than 10 mm and in patients with bilateral LM when the only possible future hepatectomy plane passes through a LM.…”

Section: Discussion Radiofrequency Ablation (Rfa)mentioning

confidence: 99%

Thermoablation of colorectal liver metastasis

Kulaylat

Gibbs

2010

Journal of Surgical Oncology

View full text Add to dashboard Cite

Thermoablation is a local therapy that is effective in in situ destruction of colorectal liver metastasis while preserving surrounding normal liver tissue. It is less invasive compared to surgery, easy to use, and can be repeated. The therapy provides local control of unresectable disease and is an alternative therapy for small resectable lesions in patients with insufficient hepatic reserve after resection or coexistent comorbid conditions. It can artificially increase the resection margin thus increasing the number of patient candidate for resection. When used in conjunction with liver resection it clears the liver of multiple lesions that are surgically inaccessible or unresectable. Main limitations of the treatment are local recurrence of the disease, treatment-related complications, and questionable impact on patient. Outcome of therapy can be improved when used as part of multimodality treatment.

show abstract

“…These results are to be balanced with the 20% 5-year survival rates obtained using chemotherapy alone in patients with unresectable CLM [5] . In such a context, it therefore appears that combined strategies mixing ablative procedures [84] and adjuvant intra-arterial chemotherapy [8] as well as repeated resection in case of recurrence could help prolong survival [85][86][87][88] .…”

Section: Long-term Outcomementioning

confidence: 99%

Surgical Results after Downstaging of Initially Marginal or Non-Resectable Liver Metastases

Cauchy

Faivre²,

Belghiti³

2012

Dig Dis

View full text Add to dashboard Cite

Surgery remains the best curative treatment for resectable patients with colorectal liver metastases. In patients initially considered unresectable, both refinements in surgical technique using portal vein occlusion or two-step resections and increased efficiency of chemotherapy regimen with the adjunction of antiangiogenics now allow secondary resection. Recent evidence suggests almost identical long-term survival in case of secondary downstaged lesions advocating an aggressive approach. However, these data lie on disparate and nonconsensual criteria for unresectability, which often do not gather technical and oncologic components together. Furthermore, both impaired general status and damaged underlying parenchyma as a consequence of prolonged chemotherapy to achieve resectability as well as the technical challenge required to perform adequate carcinologic resection could increase the operative risk in such patients. In our experience, a subgroup of slow chemo-responding initially unresectable patients who required preoperative liver volume modulation after ≥12 cycles of chemotherapy to achieve sufficient response experienced dramatically high operative risk which jeopardized postoperative chemotherapy and subsequently put these patients at increased risk of recurrence. Whether all patients preoperatively amenable to surgery using intensive chemotherapy and complex surgical strategy actually benefit from such an aggressive approach is a matter of ongoing debate, which needs a reappraisal.

show abstract

The trans‐metastasis hepatectomy (through metastases previously ablated with radiofrequency): Results of a 13‐case study of colorectal cancer

Abstract: TMPRFH is a new and safe technique, combining RF ablation and trans-RF-hepatectomy, which makes it possible to propose a curative approach in certain patients with non-resectable bilateral LMs.

Cited by 21 publications

References 26 publications

Combined liver surgery and RFA for patients with gastroenteropancreatic endocrine tumors presenting with more than 15 metastases to the liver

Combined liver surgery and RFA for patients with gastroenteropancreatic endocrine tumors presenting with more than 15 metastases to the liver

Thermoablation of colorectal liver metastasis

Surgical Results after Downstaging of Initially Marginal or Non-Resectable Liver Metastases

Contact Info

Product

Resources

About