The Traditional Uses, Phytochemistry, Pharmacokinetics, Pharmacology, Toxicity, and Applications of Corydalis saxicola Bunting: A Review

Guo, Yafei; Zhao, Lu; Chang, Botao; Yu, Jia; Bao, Jiangping; Qi, Yue; Luo, Jun

doi:10.3389/fphar.2022.822792

Cited by 7 publications

(7 citation statements)

References 42 publications

(35 reference statements)

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“…[15] Corydalis saxicola Bunting (Yan-huang-lian) belongs to the genus Corydalis (Papaveraceae), and is a traditional Zhuang ethnic herb in China that has historically been used to treat hepatitis, stomatitis, and ophthalmitis. [16] Its active ingredients, Corydalis saxicola Bunting total alkaloids (CSBTA), mostly comprise dehydrocavidine, berberine, and palmatine. [17,18] In our previous study, we observed that CSBTA can effectively suppress M1 polarization of THP-1 cells that may improve the inflammatory environment.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Corydalis saxicola Bunting Total Alkaloids on Macrophage Pyroptosis

Feng

Yong

Jiang

et al. 2023

Chemistry & Biodiversity

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This study investigated the effect of Corydalis saxicola Bunting total alkaloids (CSBTA) on pyroptosis in macrophages (Mϕ). In the Mϕ pyroptosis model, an inverted fluorescence microscope was used to assess cell pyroptosis, while a scanning electron microscope was used to observe morphological changes in Mϕ. NLR family pyrin domain‐containing 3 (NLRP3), caspase‐1, and gasdermin D (GSDMD) expression levels were detected by polymerase chain reaction and western blotting, whereas interleukin‐1 (IL‐1) and interleukin‐18 (IL‐18) expression levels were measured by an enzyme‐linked immunosorbent assay. After pretreatment with CSBTA or the caspase‐1 inhibitor, acetyl‐tyrosyl‐valyl‐alanyl‐aspartyl‐chloromethylketone (Ac‐YVAD‐cmk), it was discovered that NLRP3, caspase‐1, and GSDMD expressions were significantly reduced at both the mRNA and protein levels, as were IL‐1 and IL‐18 levels. The inhibitory effects of CSBTA and Ac‐YVAD‐cmk did not differ significantly. These findings indicate that CSBTA blocks Porphyromonas gingivalis‐lipopolysaccharide‐induced Mϕ pyroptosis.

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Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Corydalis saxicola Bunting Total Alkaloids on Macrophage Pyroptosis

Feng

Yong

Jiang

et al. 2023

Chemistry & Biodiversity

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“…[7] Total alkaloids of Corydalis saxicola Bunting (CSBTA) have been confirmed with anti-inflammatory and antioxidant effects. [8] Besides, some nonalkaloids are also isolated and identified from CSB, including steroids, flavonoids, alkanes, and uracil. [7] However, the studies on these ingredients are rarely performed compared to the CSBTA.…”

Section: Introductionmentioning

confidence: 99%

“…Total alkaloids are vital secondary metabolites of CSB, which are isolated from the whole plant through high‐speed counter‐current chromatography [7] . Total alkaloids of Corydalis saxicola Bunting (CSBTA) have been confirmed with anti‐inflammatory and antioxidant effects [8] . Besides, some non‐alkaloids are also isolated and identified from CSB, including steroids, flavonoids, alkanes, and uracil [7] .…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology and Molecular Docking Reveal the Mechanism of Corydalis saxicola Bunting Total Alkaloids in Treating Radiation‐Induced Oral Mucositis

Lai

Yong

Wei

et al. 2023

Chemistry & Biodiversity

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The study aims to explore the effect and mechanism of total alkaloids of Corydalis saxicola Bunting (CSBTA) in the treatment of radiation induced oral mucositis (RIOM) through network pharmacology and molecular docking. The components and corresponding targets of Corydalis saxicola Bunting were screened by literature review. RIOM related targets were obtained in GeneCards. Cytoscape software was used to construct the component‐target‐pathway network. Protein‐Protein Interaction (PPI) networks was constructed by String database. GO and KEGG enrichment analyses were performed by Metascape. AutoDock Vina 4.2 software was used for molecular docking. There were 26 components of CSBTA targeting 61 genes related to RIOM. Through Cytoscape and PPI analysis, 15 core target genes of CSBTA for treating RIOM were identified. GO functional analysis indicated that CSBTA might play a role through kinase binding and protein kinase activation. KEGG pathway analysis showed that the core targets of CSBTA were mainly focused on cancer and reactive oxygen species (ROS) pathway. The results of molecular docking showed that CSBTA had strong binding energy with target protein including SRC, AKT and EGFR. The study demonstrates that CSBTA may treat RIOM by affecting SRC, AKT and EGFR through ROS pathway.

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“…Corydalis saxicola Bunting (CS) is a plant of the genus Corydalis (Papaveraceae), a light green perennial herb that grows in mountain rock crevices and is majorly distributed in southern China [ 7 ]. Total alkaloids of Corydalis saxicola Bunting (TACS) are the main active components derived from CS, a natural plant extracts that has been historically used to cure inflammation, tumors and hepatic diseases [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Therapeutic Effect of Total Alkaloids of Corydalis saxicola Bunting on CCl4-Induced Liver Fibrosis in Rats by LC/MS-Based Metabolomics Analysis and Network Pharmacology

Wang

Luo

et al. 2022

Metabolites

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: Liver fibrosis is a pathological result of liver injury that usually leads to a pathophysiological wound healing response. The total alkaloids of Corydalis saxicola Bunting (TACS) have been used for hepatoprotective effects on the liver. However, its exact therapeutic mechanisms of liver fibrosis are not yet well understood. To explore the potential anti-fibrosis mechanism of TACS, metabolomics coupled with network pharmacology were applied to reveal the underlying mechanisms. Ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) combined with multivariate statistical analyses were performed to estimate changes in metabolic profiles. As a result, a total of 23 metabolites in rats with liver fibrosis were altered; of these, 11 had been downregulated and 12 had been upregulated compared with the control group. After TACS treatment, the levels of 13 metabolites were significantly restored compared with the CCl4-treated group, of which 4 metabolites were up-regulated and 9 metabolites were down-regulated. Many of these metabolites are involved in the bile acid metabolism, glutathione metabolism, tryptophan metabolism and purine metabolism. Then, three key targets, including cytochrome P450 family1 subfamily A member 1 (CYP1A1), ornithine decarboxylase 1 (OCD1) and monoamine oxidase Type B (MAOB) were predicted as potential therapeutic targets of TACS against liver fibrosis through network pharmacology analysis. Finally, palmatine, tetrahydropalmatine and dehydrocavidine were screened as potential active compounds responsible for the anti-fibrosis effect of TACS by molecular docking analysis. This study reveals that TACS exerted anti-fibrosis effects by regulating the liver metabolic pathway with multiple components and multiple targets, which is helpful to further clarify the hepatoprotective mechanisms of natural plant extracts.

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The Traditional Uses, Phytochemistry, Pharmacokinetics, Pharmacology, Toxicity, and Applications of Corydalis saxicola Bunting: A Review

Cited by 7 publications

References 42 publications

Inhibitory Effects of Corydalis saxicola Bunting Total Alkaloids on Macrophage Pyroptosis

Inhibitory Effects of Corydalis saxicola Bunting Total Alkaloids on Macrophage Pyroptosis

Network Pharmacology and Molecular Docking Reveal the Mechanism of Corydalis saxicola Bunting Total Alkaloids in Treating Radiation‐Induced Oral Mucositis

Investigation of the Therapeutic Effect of Total Alkaloids of Corydalis saxicola Bunting on CCl4-Induced Liver Fibrosis in Rats by LC/MS-Based Metabolomics Analysis and Network Pharmacology

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