The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability
Etna Abad,
Jeremy Sandoz,
Gerard Romero
et al.
Abstract:The tumor suppressor protein TP53 regulates a vast transcriptional program that serves protective mechanisms against cancer development. However, the complexity of this program makes it difficult to unravel the role of each of its targets in TP53-mediated tumour suppression. Knockdown of RNF144B, a E3-ubiquitin ligase transcriptionally regulated by TP53, enhanced the rate of tumour development and severity of malignant disease in the context of murine c-MYC-driven lymphomagenesis. Here we asked whether RNF14… Show more
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