The Toxicology Investigators Consortium 2020 Annual Report

Abstract

The Toxicology Investigators Consortium (ToxIC) Registry was established by the American College of Medical Toxicology in 2010. The registry collects data from participating sites with the agreement that all bedside and telehealth medical toxicology consultation will be entered. This eleventh annual report summarizes the Registry's 2020 data and activity with its additional 6668 cases. Cases were identified for inclusion in this report by a query of the ToxIC database for any case entered from January 1 to December 31, 2020. Detailed data was collected from these cases and aggregated to provide information which included demographics, reason for medical toxicology evaluation, agent and agent class, clinical signs and symptoms, treatments and antidotes administered, mortality, and whether life support was withdrawn. Gender distribution included 50.6% cases in females, 48.4% in males, and 1.0% identifying as transgender. Non-opioid analgesics were the most commonly reported agent class, followed by opioid and antidepressant classes. Acetaminophen was once again the most common agent reported. There were 80 fatalities, comprising 1.2% of all registry cases. Major trends in demographics and exposure characteristics remained similar to past years' reports. Sub-analyses were conducted to describe race and ethnicity demographics and exposures in the registry, telemedicine encounters, and cases related to the COVID-19 pandemic.

Deliberate Self-Poisoning: Real-Time Characterization of Suicidal Habits and Toxidromes in the Food and Drug Administration Adverse Event Reporting System

“…FAERS intoxication data provide a promising source to identify drugs reported in DSP and drive preventative actions. Coherently with recent studies [ 46 ], the most common means for DSP were psychotropic (i.e., antidepressants, antipsychotics, anxiolytics, and sedatives) and analgesic drugs (i.e., paracetamol, opioids, and NSAIDs), together with antiepileptics, antihistamines, amlodipine, metformin, and varenicline. Paracetamol was by far the most widely recorded drug, at least partly because of its availability.…”

Suspected Counterfeit M-30 Oxycodone Pill Exposures and Acute Withdrawals Reported from a Single Hospital — Toxicology Investigators Consortium Core Registry, U.S. Census Bureau Western Region, 2017–2022

“…Medical toxicologists participating in the ToxIC Core Registry collect patient data from bedside consultations (e.g., patient or proxy interviews, physical examination, and ancillary data). Variables collected include patient demographic characteristics, exposures (i.e., specific drugs taken), clinical presentation (e.g., respiratory depression), treatments administered (e.g., naloxone), and outcomes (e.g., hospitalization) ( 3 ).…”

The Food and Drug Administration’s (FDA’s) Drug Safety Surveillance During the COVID-19 Pandemic

“…In 2010, the ACMT established the Toxicology Investigators Consortium as a multicenter toxico-surveillance and research network of medical toxicologists and has continued expanding the capabilities of the registry to serve as a database for public health surveillance and emerging concerns within the field of toxicology, including AEs [ 12 , 13 ]. In response to the COVID-19 pandemic, the FDA contracted with ACMT’s Toxicology Investigators Consortium to establish the FACT Pharmacovigilance Project Sub-registry to leverage the existing capabilities of the Toxicology Investigators Consortium registry as a surveillance tool to identify emerging safety issues associated with drugs to treat or prevent COVID-19 [ 14 ].…”