“…There are numerous applications for silica nanoparticles (SiNP) and it can be used in many fields, such as chemical industries, biomarkers in medicine, cosmetics, paints, food and medicine (WEI et al, 2010;FEDE et al, 2012). Several studies have shown that these particles can cause damage to human cells (LU et al, 2011;LIN et al, 2006;EOM;CHOI, 2009;SUN et al, 2011;PASSAGNE et al, 2012), complications on pregnancy (YAMASHITA et al, 2011), inhibition of DNA replication and transcription (CHEN; VON MIKECZ, 2005), and heart and lung injury in rats (CHEN et al, 2008).…”