The toxicity of some dithiocarbamate compounds in young and adult domestic fowl

Rasul, Ammar; Howell, Jahna

doi:10.1016/0041-008x(74)90247-6

Cited by 22 publications

(9 citation statements)

References 20 publications

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“…As such, oxidative stress biomarkers are important and relevant in toxicological studies. Moreover, because of its structure, thiram has 2 potential effects: it has an oxidizing effect as a result of its disulfide bridge that may interact with sulfhydryl groups of proteins and cofactors, but also a reductive effect due to its sulfhydryl group of the dimethyldithiocarbamate anion . In the present study, an increase in SOD activity was observed in red blood cells in partridges exposed to both doses of thiram (Figure ).…”

Section: Discussionsupporting

confidence: 54%

“…Oxidative damage also could explain the well-documented capacity of thiram to produce tibial dyschondroplasia [17]. Finally, morphological alterations of the reproductive organs [6,18,19] and effects on egg production and fertility [9,18,19,20,] have been reported after thiram administration. Sperm damage attributable to free radicals is a main cause of infertility in males [21].…”

Section: Introductionmentioning

confidence: 99%

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Adverse effects of thiram‐treated seed ingestion on the reproductive performance and the offspring immune function of the red‐legged partridge

López-Antia

Ortiz‐Santaliestra

Blas

et al. 2015

Enviro Toxic and Chemistry

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Pesticide research traditionally has focused on compounds with high acute toxicity or persistence, but the adverse sublethal effects of pesticides with different properties also may have important consequences on exposed wildlife. The authors studied the effects of thiram, a fungicide used for seed coating with known effects as endocrine disruptor. Red-legged partridges (Alectoris rufa; n = 15 pairs per treatment group) were fed wheat treated with 0%, 20%, or 100% of the thiram application rate used in autumn (25 d) and late winter (10 d) to mimic cereal sowing periods. The authors studied the effects on reproductive performance, carotenoid-based ornamentation and cellular immune responsiveness of adult partridges, and their relationship with changes in oxidative stress biomarkers and plasma biochemistry. The authors also studied the effect of parental exposure on egg antioxidant content and on the survival, growth, and cellular immune response of offspring. Exposure to thiram-coated seeds delayed egg laying, reduced clutch size, and affected egg size and eggshell thickness. Partridges exposed to the 20% thiram dose exhibited reduced egg fertility and brood size (55% and 28% of controls, respectively). Chick survival was unaffected by parental exposure to treated seeds, but adverse effects on their growth rate and cellular immune response were apparent. These effects on reproduction and immune function may have important demographic consequences on farmland bird populations.

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Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Adverse effects of thiram‐treated seed ingestion on the reproductive performance and the offspring immune function of the red‐legged partridge

López-Antia

Ortiz‐Santaliestra

Blas

et al. 2015

Enviro Toxic and Chemistry

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“…Dithiocarbamates are fungicides and herbicides that inhibit reproduction in birds (Rasul and Howell, 1974;Weppelman et al, 1980;Serio et al, 1984) and mammals . Both egg production and ovarian weights were reduced when laying hens were fed diets containing thiocarbamates, e.g.…”

Section: Pesticides (Fungicides Herbicides and Insecticides)mentioning

confidence: 98%

Avian Models for Research in Toxicology and Endocrine Disruption

Scanes¹,

McNabb²

2003

Avian & Poul. Biolog. Rev.

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There have been significant strides in our knowledge of the effects of toxicants on birds. This communication presents a brief review of avian toxicology with emphasis on effects of common toxicants that disrupt endocrine system function and control of reproduction, growth, development, stress and calcium-phosphorus homeostasis. For those hormonal systems that act through hypothalamic-pituitary axes, we emphasize current knowledge of the axis``level'' at which the toxicants alter endocrine control. The classes of toxicants discussed are acid rain andyor aluminum, organochlorines such as polychlorinated biphenyls (PCBs), fungicides and insecticides, mycotoxins, (PCBs) and petroleum. The use of several types of avian models for endocrine disruption studies is discussed in the context of utility and practicality, developmental modes, species sensitivity and the choice of sentinel species. Promising new approaches for avian toxicological research are considered including shell-less embryos, continuous-flow administration of toxicants to avian embryos, gene microarrays, proteomics and metabolomics.

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“…Ancak, çoğunun toprakta ya da bitkilerde orta derecede kalıcı özel-likleri vardır ve uygulama alanlarında 4-16 hafta süreyle parçalan-madan kalabilmektedirler (7). İsolan uygulanmadan sonra 10-20 gün, Aldikarb 50 günden fazla kalıcı etkinlik göstermektedir (8,12 …”

Section: Karbamat1arunclassified

SIGIR VE KOYUNLARDA BİR KARBAMAT PESTİsİD OLAN ALDİKARB'IN SEBEP OLDUGU BİR TOPLU ZEHİRLENME OLA YI

Sezai¹

1985

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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The toxicity of some dithiocarbamate compounds in young and adult domestic fowl

Cited by 22 publications

References 20 publications

Adverse effects of thiram‐treated seed ingestion on the reproductive performance and the offspring immune function of the red‐legged partridge

Adverse effects of thiram‐treated seed ingestion on the reproductive performance and the offspring immune function of the red‐legged partridge

Avian Models for Research in Toxicology and Endocrine Disruption

SIGIR VE KOYUNLARDA BİR KARBAMAT PESTİsİD OLAN ALDİKARB'IN SEBEP OLDUGU BİR TOPLU ZEHİRLENME OLA YI

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