The Toxicity of Newer and Lesser-Known Anticonvulsant Drugs

Walsh, Steven J.; Chen, Richard J.; Ershad, Muhammed; Krueger, James A.

doi:10.1007/s40138-020-00220-7

Cited by 3 publications

(3 citation statements)

References 60 publications

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“…Common side effects of felbamate are loss of appetite, vomiting, insomnia, nausea, dizziness and headache, while serious side effects include aplastic anemia and liver failure [ 36 , 108 ]. Therefore, monitoring transaminases, coagulation parameters, and blood counts of patients receiving felbamate may be required.…”

Section: Broad and Narrow Spectrum Anti-seizure Drugsmentioning

confidence: 99%

Elucidating the Potential Side Effects of Current Anti-Seizure Drugs for Epilepsy

Akyüz

Köklü

Ozenen

et al. 2021

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: Over the decades, various interventions have been developed and utilized to treat epilepsy. However, majority of epileptic patients are often first prescribed with anti-epileptic drugs (AED), now known as anti-seizure drugs (ASD), as a first line of defense to suppress their seizures and regain their quality of life. ASDs exert their anti-convulsant effects through various mechanisms of action including regulation of ion channels, blocking of glutamate-mediated stimulating neurotransmitter interaction, and enhancing the inhibitory GABA transmission. About one third of epileptic patients are often resistant to anti-convulsant drugs, while others develop numerous side effects which may lead to treatment discontinuation and further deterioration of quality of life. Common side effects of ASDs include headache, nausea and dizziness. However, more adverse effects such as auditory and visual problems, skin problems, liver dysfunction, pancreatitis and kidney disorders may also be witnessed. Some ASDs may even result in life-threatening conditions as well as serious abnormalities, especially in patients with comorbidities and in pregnant women. Nevertheless, some clinicians had observed a reduction in the development of side effects post individualized ASD treatment. This suggest that a careful and well-informed ASD recommendation to patients may be crucial for an effective and side-effect free control of their seizures. Therefore, this review aimed to elucidate the anticonvulsant effects of ASDs as well as their side effect profile, by discussing their mechanism of action and reported adverse effects based on clinical and preclinical studies, thereby providing clinicians with a greater understanding of the safety of current ASDs.

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Section: Broad and Narrow Spectrum Anti-seizure Drugsmentioning

confidence: 99%

Elucidating the Potential Side Effects of Current Anti-Seizure Drugs for Epilepsy

Akyüz

Köklü

Ozenen

et al. 2021

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“…139 Common side effects of felbamate are loss of appetite and insomnia, while serious side effects include aplastic anemia and liver failure. 140 Epileptic individuals who use zonisamide may experience anorexia, weight loss, somnolence, nervousness, and sleep disorders. In addition, more serious side effects, such as vertigo, reduced sweating, and pancreatitis, have also been reported in patients occasionally.…”

Section: Potential Side Effects Of Antiepileptic Drugsmentioning

confidence: 99%

“…Additionally, a range of behavioral issues, including aggression, have also been commonly observed in these patients . Common side effects of felbamate are loss of appetite and insomnia, while serious side effects include aplastic anemia and liver failure . Epileptic individuals who use zonisamide may experience anorexia, weight loss, somnolence, nervousness, and sleep disorders.…”

Section: Potential Side Effects Of Antiepileptic Drugsmentioning

confidence: 99%

Anticonvulsant Classes and Possible Mechanism of Actions

Abd-Allah,

El-Mohsen Anwar,

Mohammed

et al. 2023

ACS Chem. Neurosci.

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Epilepsy is considered one of the most common neurological disorders worldwide; it needs long-term or life-long treatment. Despite the presence of several novel antiepileptic drugs, approximately 30% patients still suffer from drug-resistant epilepsy. Subsequently, searching for new anticonvulsants with lower toxicity and better efficacy is still in paramount demand. Using target-based studies in the discovery of novel antiepileptics is uncommon owing to the insufficient information on the molecular pathway of epilepsy and complex mode of action for most of known antiepileptic drugs. In this review, we investigated the properties of anticonvulsants, types of epileptic seizures, and mechanism of action for anticonvulsants.

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Antiepileptic and Psychotropic Drugs

Bircher,

Brockow

2022

Cutaneous Drug Hypersensitivity

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The Toxicity of Newer and Lesser-Known Anticonvulsant Drugs

Cited by 3 publications

References 60 publications

Elucidating the Potential Side Effects of Current Anti-Seizure Drugs for Epilepsy

Elucidating the Potential Side Effects of Current Anti-Seizure Drugs for Epilepsy

Anticonvulsant Classes and Possible Mechanism of Actions

Antiepileptic and Psychotropic Drugs

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