The Toxicity of Fluorides in Relation to their Use in Dentistry

Flural—A New Flocculating‐Fluoridating Agent

“…Hampel (9) has included some toxicological would be 5.5 g for sodium fluoride, 8.5 g for sodium fluosilicate and 45 g for Flural. These calculated values for the NaF and Na 2SiF6 come within the range reported in the literature for acutely toxic levels of these two salts (10).…”

National Research Council Viewpoint on Fluoridation

“…There is an extensive literature on the pharmacology and toxicology of fluorine and its compounds. This field has been reviewed by several authors (9)(10)(11)(12). Only those parts of it which deal with the cumulative action of fluorides are pertinent to the question of the safety of fluoridation.…”

The Advancement of Fluoridation

“…During this seven years since the Cleveland meeting much additional basic work, epidemiological and laboratory, has become available. Toxicity studies recently summarized by Cox and Hodge (5) justify the conclusion that chronic, crippling fluorosis will never appear as a result of dental uses of fluorides and that, when the addition of fluoride ion is limited to about 1 ppm., mottled enamel, the most delicate sign of fluoride toxicity, will be found only in a very few individuals, and then in very mild form. No unaesthetic marring of the teeth should occur.…”