The Toxicity of Disulphides to Isolated Hepatocytes and Mitochondria

Jatoe, S. D.; Lauriault, Veronique; McGirr, Larry G.; O’Brien, Peter J.

doi:10.1515/dmdi.1988.6.3-4.395

Cited by 11 publications

(1 citation statement)

References 4 publications

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“…This is to be considered because the disulfide metabolites of sulfur-based drugs were 50-100 times more toxic on hepatocytes from isolated rats than the parent drugs. 24…”

Section: Discussionmentioning

confidence: 99%

Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries

Secrétan¹,

Antignac²,

Yagoubi³

et al. 2020

BMJ Open

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ObjectivesThe incidence of cardiovascular diseases is increasing and there is a growing need to provide access to quality cardio drugs in Africa. In the SEVEN study, we analysed 1530 cardiovascular drug samples randomly collected from 10 African countries. By that time, of the seven drugs products analysed, only those containing amlodipine and captopril had very low assay values with active substance contents that could be less than 75% of those expected. In this article we investigate complementary aspects of the amlodipine and captopril samples so to explain the previously observed low assays for these two drugs.DesignPost hoc analysis of the captopril and amlodipine drugs samples and their packages collected in the context of the SEVEN study.Setting10 countries were concerned: Benin, Burkina Faso, Congo, Democratic Republic of the Congo, Guinea, Côte d’Ivoire, Mauritania, Niger, Senegal and Togo.ParticipantsLocal scientists and hospital practitioners collected the drug samples in the 10 African countries.Outcome measuresThe drug amount and the relative amounts of drug impurities, as well as the main compounds of the drugs packaging, were analysed.ResultsIdentification of the blister packaging of the samples led to separate both amlodipine and captopril drug samples in two groups. Mann Whitney’s bilateral test showed a significant difference (p<0.0001) between the median value of the captopril dosage when tablets are packaged in blisters providing higher protection to humidity (n=105) as opposed to the tablets packaged in blisters providing lower humidity protection (n=130).ConclusionBased on these results, particular attention should be paid to the materials and types of packaging used in order to minimise the lack of control over the exposures and drug circuits present in these different countries.

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“…This is to be considered because the disulfide metabolites of sulfur-based drugs were 50-100 times more toxic on hepatocytes from isolated rats than the parent drugs. 24…”

Section: Discussionmentioning

confidence: 99%