The toxicity of bis(tri-n-butyltin)oxide (TBTO) and di-n-butyltindichloride (DBTC) in the small fish species Oryzias latipes (medaka) and Poecilia reticulata (guppy)

Wester, Piet W.; Canton, J.H.; Iersel, A.A.J. van; Krajnc, E.I.; Vaessen, H. A. M. G.

doi:10.1016/0166-445x(90)90077-3

Cited by 62 publications

(32 citation statements)

References 18 publications

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“…The only previous comparative in vivo study of immunomodulative effects of TBT and DBT on blue mussels reported that both butyltins altered immune parameters at doses between 5 and 80 ng Sn l -1 within 10 d of exposure (St-Jean et al 2002). It has been suggested that DBT could be selectively immunotoxic, affecting only the immune system with no apparent effects on other organs/systems (Wester et al 1990). In light of these reports, there is an urgent need to reassess the toxicity, and particularly the immunotoxicity, of DBT.…”

Section: Discussionmentioning

confidence: 99%

“…However, one of the key problems encountered in ecotoxicology is that certain compounds are species-or even organ-and system-specific, and hence any extrapolation about general toxicity of a given pollutant is to be considered carefully (Fent 1996). Information available on the immunotoxicity of butyltins, especially for aquatic organisms, is not only scarce but also conflicting, presumably reflecting differences among species and organs studied and methods used (Seinen et al 1981, Snoeij et al 1988, Wester et al 1990). …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Very low levels of waterborne butyltins modulate hemocyte function in the blue mussel Mytilus edulis

St-Jean¹,

Pelletier²,

Courtenay³

2002

Mar. Ecol. Prog. Ser.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Very low levels of waterborne butyltins modulate hemocyte function in the blue mussel Mytilus edulis

St-Jean¹,

Pelletier²,

Courtenay³

2002

Mar. Ecol. Prog. Ser.

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“…Moreover, it may be a useful alternative or supplement in established mammalian toxicology and carcinogenesis. As reference information, we have studied the histopathologic response of 2 small laboratory fish species Poecilia reticulata (guppy) and Oryzias latipes (Japanese medaka) to various environmental contaminants (40)(41)(42)(43)(44)(45). In this paper, the results of the study with methyl mercury chloride in guppies are presented.…”

Section: Introductionmentioning

confidence: 99%

Histopathological Effects in Poecilia reticulata (Guppy) Exposed to Methyl Mercury Chloride

Wester

Canton

1992

Toxicol Pathol

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To evaluate the usefulness of histopathology in aquatic toxicity testing, studies were carried out on the small freshwater fish Poecilia reticulata (guppy) following aqueous methyl mercury chloride exposure. Fish were exposed to concentrations of 0, 1.0, 1.8, 3.2, 5.6, or 10 μg/L for 1 and 3 months. Histopathological changes included the occurrence of multiple granulomas in various tissues, in particular, the integument and orbit. These changes were accompanied by hyperplasia of monocytopoietic interrenal tissue, and hepatocellular change which was confirmed by morphometry. The latter findings were probably a result of monocyte "consumption" by granulomas, and hepatic synthesis of ("stress") proteins, respectively. The bile duct and, focally, the proximal intestine, showed hyperplasia of the epithelium. In the testis of sexually mature fish (3-month study), degeneration and necrosis of sperm occurred, with severe cases exhibiting Sertoli cell hypertrophy, interstitial inflammation, and absence of mature sperm. Epidermal mucous cells disappeared in the highest concentration used, and, after 3 months, clusters of undifferentiated basophilic cells were seen in the gas gland, which occasionally were suggestive of malignant growth. The changes in the kidney tubules were characterized by degeneration and necrosis of single cells which also showed mitotic figures. This is considered a result of the mitosis-disturbing activity of methyl mercury (MeHg). It is concluded that MeHg has effects on various target organs in guppies with the occurrence of granulomas as the most sensitive indicator, yielding a no-observed-effect concentration (NOEC) of 1.0 μg/L. In contrast to mammalian species, no morphologic evidence for neurotoxicity was found.

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“…Accumulation of fat can result in of either toxic exposure or nutritionally induced. Increased hepatic glycogen has been demonstrated histologically, histochemically and biochemically in Oryzias latipes (medaka) and Poecilia reticulata (guppy) those were exposed to bis (tri-nbutyltin) oxide (TBTO) and di-n-butyltindichloride (DBTC) (Wester et al 1990). Microvesicular steatosis has also been reported in tilapia exposed in MC-LR (Atencio et al 2008).…”

Section: Fifteen Days Exposurementioning

confidence: 80%

Effects of toxic Microcystis aeruginosa bloom on liver of nile tilapia (Oreochromis niloticus)

Ahmed

Giese

Schulz

et al. 2017

Bangladesh J. Zool.

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Abstract:The effects of toxic Microcystis aeruginosa on the liver of Nile tilapia, Oreochromis niloticus were investigated in the laboratory. Four treatments were setup into aquariums for 15 days to investigate the histopathological changes exposed to Microcystis aeruginosa bloom. Fishes of treatment A1 were treated as a control group and given artificial feed. In the three treatments (A2, A3 and A4), the M. aeruginosa cell concentration were 35 × 10 2 , 72 × 10 2 , 149 × 10 2 colony/ml, respectively. In the control group, no histopathological change was observed. In exposed fish, histopathological alterations were characterized by swollen and granular cytoplasm, vascular proliferation, bile stasis, fatty change and focal necrosis. Histopathological changes were observed within five days of exposure when fish exposed to moderate (72 × 10 2 colony/ml) to high (149 × 10 2 colony/ml) bloom concentration, whereas it took 15 days in lower concentration (35 × 10 2 colony/ml). Histopathological changes proved that intake of toxic M. aeruginosa bloom by aquatic animals, particularly Nile tilapia has significant effects on its internal organs that may cause of massive mortality. Accordingly, cyanotoxin accumulation in fish tissue my pose a risk to human health through the food chain.

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The toxicity of bis(tri-n-butyltin)oxide (TBTO) and di-n-butyltindichloride (DBTC) in the small fish species Oryzias latipes (medaka) and Poecilia reticulata (guppy)

Cited by 62 publications

References 18 publications

Very low levels of waterborne butyltins modulate hemocyte function in the blue mussel Mytilus edulis

Very low levels of waterborne butyltins modulate hemocyte function in the blue mussel Mytilus edulis

Histopathological Effects in Poecilia reticulata (Guppy) Exposed to Methyl Mercury Chloride

Effects of toxic Microcystis aeruginosa bloom on liver of nile tilapia (Oreochromis niloticus)

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