The Toxicity of Aluminum Chloride on Kidney of Rats

Liu, Jianyu; Wang, Qin; Sun, Xudong; Yang, Xu; Zhuang, Cuicui; Xu, Feibo; Cao, Zheng; Li, Yanfei

doi:10.1007/s12011-016-0648-9

Cited by 26 publications

(16 citation statements)

References 26 publications

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“…Yang et al, 2017, proved that the inflammatory cytokines have a stimulating effect on the accumulation of neutrophils to increase the injury of inflammation in the liver tissue. The present results are also in harmony with liu et al, 2016 andHammad, 2018, who found an increase in TNF-α and IL-6 in the liver and kidney of rats treated with AlCl3.…”

Section: Discussionsupporting

confidence: 92%

Syzygium cumini (L) Extract Ameliorates Aluminium Chloride-Induced Acute Hepatic and Renal Toxicity in Rats

Salem

2021

Egyptian Academic Journal of Biological Sciences. C, Physiology

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Aluminium (Al) is the most common metallic element associated with pathogenesis in humans and animals. This study was conducted to evaluate the ability of Syzygium cumini (L.) leaves extract in attenuating the acute toxicity of aluminium-induced hepatic and renal toxicity in rats. Male rats were received oral administration of AlCl3 (150mg/kg) followed by oral administration of S. cumini (250mg/kg) leaves extract for 14 days. Aluminium concentration, MDA, NO, glutathione, oxidative enzymes (catalase, superoxide dismutase, glutathione reductase and glutathione peroxidase) was measured in liver and kidney homogenate. In addition, we demonstrate the level of serum and liver AST, ALT, ALP and serum urea and creatinine. Compared to the control group, the animal that received Al showed a significant elevation in the tissue level of Al, MDA, NO and reduction in the level of glutathione and antioxidant enzymes. It also showed a marked increase in serum liver function enzymes, creatinine and urea. The combined treatment with S. cumini leaves extract caused restoration of the oxidative levels and upregulation in antioxidant enzymes as compared to Al-intoxicated rats. In addition, the administration of S. cumini extracts in rats after Al administration caused a decrease in cytokines TNF-α and IL-6, Bax & caspase-3 expression, in addition, to an increase in antiapoptotic marker Bcl2 in liver and kidney homogenate. In conclusion, our study revealed that the treatment with S. cumini leaves extracts ameliorates hepatic and renal cells toxicity produced by Al exposure by elevating the antioxidant enzymes, antiapoptotic and anti-inflammatory activity.

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Section: Discussionsupporting

confidence: 92%

Syzygium cumini (L) Extract Ameliorates Aluminium Chloride-Induced Acute Hepatic and Renal Toxicity in Rats

Salem

2021

Egyptian Academic Journal of Biological Sciences. C, Physiology

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“…Al causes a wide range of toxicity in the nervous, hematopoietic, skeletal, respiratory, and immune systems (3,4).…”

Section: Introductionmentioning

confidence: 99%

Comparing the Effects of Saccharomyces boulardii and Selenium-Enriched S. boulardii on Hematological Parameters and Total Antioxidant Capacity in Aluminum Induced Toxicity in Rats

Yaghchi

Fatemi

Ghandehari

2018

J Kermanshah Univ Med Sci

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Background: Oxidative stress induced by aluminum (Al) toxicity leads to the dysfunction of the hematopoietic system. Detoxifying by means of common chelators causes many side effects. Therefore, researchers have been trying to find safer treatments. Objectives: This study aimed to evaluate the effects of Saccharomyces boulardii and S. boulardii enriched with selenium (Se) on Alinduced toxicity in rats. Methods: Female rats were divided into 6 groups: (A) Control group, (B) S. boulardii treatment group, (C) enriched S. boulardii treatment group, (D) Al-infected group, (E) S. boulardii treated and Al-infected group, (F) enriched S. boulardii treated and Al-infected group. At the end of the treatment period, blood samples were taken directly from the hearts of rats in order to measure hematological parameters, total antioxidant capacity (T-AOC), malondialdehyde (MDA) concentrations, iron, and total iron binding capacity (TIBC). Results: Results revealed significant increases of white blood cells (WBC), red cell distribution width (RDW), TIBC and MDA in group D as compared to the control group and significant reductions of these factors in groups E and F as compared to group D. T-AOC, iron, and mean corpuscular volume (MCV) decreased in group D as compared to the control group, but significantly increased in groups E and F as compared to group D. Other observed changes were not statistically significant. Conclusions: It appears that S. boulardii partly reduced the harmful effects of Al toxicity, especially when enriched with Se due to its antioxidant properties. Further studies are needed in this area.

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“…Rats were obtained from El Osman Farm, Cairo, Egypt, housed in stainless steel cages, and provided with food, water, and libitum . Aluminum chloride was received daily at a dose of 1.6 ml/l added to the drinking water ( 18 , 19 ).…”

Section: Methodsmentioning

confidence: 99%

Effect of Allium sativum and Nigella sativa on alleviating aluminum toxicity state in the albino rats

et al. 2022

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The study objective was to evaluate Allium sativum's potential and Nigella Sativa's combination's potential to reduce aluminum toxicity and return to the normal state. In the present study, a hundred albino rats were randomly divided into five equal groups. The first group was used as a control group; the other four groups were exposed to aluminum 1,600 ppm. The second exposed to aluminum only; the third and fourth groups were treated with Allium sativum 5% and Nigella sativa 5%, respectively, while the fifth group was treated with a mix of Allium sativum 2.5% and Nigella sativa 2.5% for 8th weeks. After 8 weeks, the aluminum administration was stopped, and the second group was divided into three groups. The groups were treated with Allium sativum 5% and Nigella sativa 5%, and a mix of Allium sativum 2.5% and Nigella sativa 2.5%, respectively. The first group was the control group (continued from the first experiment). Garlic and Nigella sativa were crushed and added to feed while receiving aluminum chloride daily at a dose of 1.6 ml/l was added to the drinking water. Histopathological changes in the liver, kidney, and testes were investigated after 8 and 16 weeks, and blood samples were collected after 4, 8, and 16 weeks for biochemical blood parameters. The results showed that the histopathological examination of the liver, kidney, and testes showed signs of congestion in blood vessels after aluminum exposure. Meanwhile, the treatment with Allium sativum or Nigella sativum or the mixture between them had positive effects on evading the harmful effects of aluminum in the liver, Kidney, and testes tissues. In addition, there were protective effects for Allium sativum and Nigella sativa against aluminum on serum creatinine, urea, ALT, and AST concentrations. The present study concluded that supplementation with Allium sativum or Nigella sativa or their combination could reduce aluminum toxicity and return the liver, kidney, and testes to normal.

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The Toxicity of Aluminum Chloride on Kidney of Rats

Cited by 26 publications

References 26 publications

Syzygium cumini (L) Extract Ameliorates Aluminium Chloride-Induced Acute Hepatic and Renal Toxicity in Rats

Syzygium cumini (L) Extract Ameliorates Aluminium Chloride-Induced Acute Hepatic and Renal Toxicity in Rats

Comparing the Effects of Saccharomyces boulardii and Selenium-Enriched S. boulardii on Hematological Parameters and Total Antioxidant Capacity in Aluminum Induced Toxicity in Rats

Effect of Allium sativum and Nigella sativa on alleviating aluminum toxicity state in the albino rats

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