The toxic effects of electronic cigarette aerosol and cigarette smoke on cardiovascular, gastrointestinal and renal systems in mice

Xu, Aijing; Duan, Kun; Yang, Wanchun; Feng, Guodong; Wu, Zehong; Jiang, Xingtao; Li, Min; Liu, Peiqing; Chen, Jianwen

doi:10.1038/s41598-023-39201-7

Cited by 2 publications

(1 citation statement)

References 60 publications

(55 reference statements)

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“…Different studies indicate exclusive ENDS consumption, compared to TTCs, is associated with a "less damaging" risk profile [ 75 , 76 ]. A drop in thirteen biomarkers (12 renal, one hematological) was reported upon switching to ECs, implicating better cardiovascular parameters for individuals switching from TC to EC [ 77 ].…”

Section: Reviewmentioning

confidence: 99%

Understanding the Cardiovascular Fallout of E-cigarettes: A Comprehensive Review of the Literature

Chaturvedi,

Attia Hussein Mahmoud,

Isaac

et al. 2024

Cureus

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E-cigarettes (ECs) deliver chemicals, including nicotine. They can cause respiratory distress, addiction, cardiovascular effects, and death. More research is needed, especially regarding their impact on the cardiovascular system (CVS) and during pregnancy. Our article aims to fill this gap by summarizing studies elaborating upon the current impact of ECs and the components thereof on the CVS. Acute respiratory distress outbreaks, nicotine addiction, CVS effects, and deaths have been occasionally reported within this cohort, although these events are not uncommon with neighboring age groups. Randomized control trials implying ECs have some contribution toward quitting smoking have been studied. To regulate EC distribution, the Food and Drug Administration (FDA) and Centers for Disease Control and Prevention (CDC) have created key checkpoints. Additionally, taxation, pricing, age restriction, and media campaigns could be modulated to significantly reduce illicit sales. Education to the users, distributors, and regulators about this product can also play an aiding role in promoting responsible EC use. Another strategy about licensing could be employed, which could incentivize genuine resellers. The effects on CVS and child-bearing by ECs are grim, which calls for strict regulation, awareness, and avoidance by the teetotaler public. They may help individuals stop smoking but not without harming themselves. Strict regulations are necessary to prevent non-judicious use of these devices.

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Section: Reviewmentioning

confidence: 99%

Understanding the Cardiovascular Fallout of E-cigarettes: A Comprehensive Review of the Literature

Chaturvedi,

Attia Hussein Mahmoud,

Isaac

et al. 2024

Cureus

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Tobacco and Nicotine Products Adverse Health Events: Findings From the FDA Safety Reporting Portal

Barrientos,

Dabroy,

Ebrahimi Kalan

et al. 2024

Tob Use Insights

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Introduction The FDA oversees regulatory aspects of all U.S. tobacco products. Understanding the impact of emerging health trends and incidents associated with various tobacco and nicotine products is vital for public health. This study utilizes the FDA’s Tobacco Product Problem Reports (TPPRs) to characterize and track adverse health events (AHEs) associated with tobacco and nicotine products over time, considering the impact of EVALI and the COVID-19 pandemic. Methods FDA TPPRs from 2017-2022 provided information on AHEs related to various tobacco products. After data cleaning, 839 reports were categorized by two independent coders based on affected health category, frequency of AHEs reports, and proportion of AHEs per each health category. Additionally, variations in AHEs over time were assessed, considering major health events like EVALI and the COVID-19 pandemic. Results Among the 839 reports, electronic cigarettes (e-cigarettes) were the primary product of concern, comprising 90.6% (n = 760) of all reports, surpassing traditional cigarettes (5.1%; n = 43) and other products. Notably, 45.6% of reports (n = 383) identified the neurological system as the most frequently mentioned health category, each reporting at least one AHE. This was followed by the respiratory (39.1%; n = 328) and digestive (10.7%; n = 90) systems. Among all reported AHEs, respiratory system issues were most frequent (25.9%; n = 512), closely followed by neurological (25.2%; n = 499) and digestive (6.6%; n = 131) concerns. Most reports occurred in 2019 (65.7%; n = 551), coinciding with the EVALI outbreak, with a subsequent decline post-Q3 2019, highlighting the potential impact of specific health crises on reporting trends. Conclusion E-cigarettes dominated adverse health reports, particularly affecting the neurological and respiratory systems, with a peak in 2019. Our findings provide insights to regulatory entities and future research, enhancing understanding of AHEs in lesser-explored bodily systems, such as the neurological and digestive systems. This study emphasizes the need for ongoing and improved surveillance of emerging tobacco products to protect public health.

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The toxic effects of electronic cigarette aerosol and cigarette smoke on cardiovascular, gastrointestinal and renal systems in mice

Cited by 2 publications

References 60 publications

Understanding the Cardiovascular Fallout of E-cigarettes: A Comprehensive Review of the Literature

Understanding the Cardiovascular Fallout of E-cigarettes: A Comprehensive Review of the Literature

Tobacco and Nicotine Products Adverse Health Events: Findings From the FDA Safety Reporting Portal

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