The total synthesis of streptonigrin and related antitumor antibiotic natural products

Facile synthesis, characterization and DFT calculations of 2-acetyl pyridine derivatives

“…Synthesis of 2-Methyl-1-(pyridine-2-yl)propane-1-one, 1 Following the literature procedure 31,32 with modification, a 250 mL round bottom flask was charged with 29 mmol L -1 (3.53 g, 2 mL) of 2-Acetylpyridine in 58 mL dry toluene. After some time 3 equivalents, 2.1 g of Sodium hydride and 0.2 mol% of 18-crown-6-ether were added and the mixture was stirred for 20 minutes followed by addition of 2 equivalents (3.5 mL) of iodomethane.…”

“…1 Nitrogen containing heterocyclic compounds have anti-allergic, 2 antimicrobial, [3][4][5][6][7][8][9][10] anti-bacterial, anti-fungal, 11,12 anti-inflammatory, 13,14 and anti-cancer 15,16 activities. Many ligands derived from pyridine containing precursors are capable to couple with metals, the resulted complexes exhibit anti-tumor activities.…”

A facile one-pot synthesis of 2-(2-pyridyl)quinolines via Povarov reaction

“…In view of the importance of producing streptonigrin derivatives, several methods were developed for the synthesis of 2-(2-pyridyl)quinolines 10 . However, many of the synthetic protocols reported so far suffer from various disadvantages, including harsh reaction conditions, multistep reaction, expensive reagents lengthy reaction times, requirement of large amount of catalyst and low yield of desired products 11 .…”

Synthesis and anti-inflammatory activity of 3-indolyl pyridine derivatives through one-pot multi component reaction

“…[6][7] The pyridine nucleus is prevalent in numerous natural products and is extremely important in chemistry of biological systems. 8 It plays a key role catalysing both biological and chemical systems. In many enzymes of living organisms it is the prosthetic pyridine nucleotide (NADP) that is involved in various oxidation-reduction processes.…”

“…12 Pyridine derivatives containing multi-functional groups such as streptonigrin, streptonigrone and lavendamycin are reported as anticancer drugs, and cerivastatin is reported as the HMG-CoA enzyme inhibitor. 8 Moreover, substituted pyridines are reported as leukotriene B-4 antagonists. [13][14][15] 3-Substituted indole is the one of the 'privileged medicinal scaffold,' found in many biologically active compounds and natural products.…”