The Total Synthesis of Quadrone

Sesquiterpenoids

“…The first of these involves the formation of the keto-ester (37O)l6O (Scheme 61), a compound which has been previously converted into quadrone by Danishefsky et a1. 161 The critical transmutation of ( 368) to (369) afforded an interesting study of site-selective reactivity in a polyfunctional molecule, and this has been the subject of a separate paper.l6*…”