The Total Synthesis of Cephalosporin C¹

Synthesis of nor-anatoxin-a and anatoxin-a

“…Alternatively, the ketone 8 was isolated, then converted into the en01 acetates by acetic anhydride in the presence of hydrogen bromide. Addition of bromine to the en01 acetates, followed by aqueous work-up gave the bromo ketone 11 I n contrast to the behavior of the etdo isomer, the action of lithium in ammonia on the exo isomer 6 only resulted in reduction of the carbonyl group.…”

“…De-N-methylation of N-methyl anatoxin using 2,2,2-trichloroethoxycarbonyl chloride ( 11) proved to be erratic, and the zinc deblocking of the nitrogen was not clean, so this method was not pursued further.…”

Totalsynthese von Nosiheptid

“…[98,106,115,217,218] 63 Für die Synthese des Pyridylthiazols 160 wurde das aus L-Cystein abgeleitete Thioamid 47 [98] mit dem -Bromketon 161 [219] …”

The effect of structural variations on the properties of polycarbonates susceptible to thermolytic or acidolytic degradation

“…However, the latter method is not suitable for tertiary diols, due to the instability of the corresponding chloroformates [12]. But activation of tertiary and other diols is possible with carbonyldiimidazole [13] or with 4-nitrophenylchloroformate [14] and both methods have been applied [3,5] successfully to the synthesis of labile polycarbonates.…”