The topographical distribution of interhemispheric projections in the corpus callosum of the rhesus monkey

Pandya, Deepak N.; Karol, Eduardo A.; Heilbronn, D.

doi:10.1016/0006-8993(71)90153-3

Cited by 358 publications

(124 citation statements)

References 13 publications

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“…It presents with a topographical representation of the different cortical areas as established in different placental mammals (reviewed in [22]). In macaque the topography reflects the wide diversity of fiber calibers [12,[23][24][25]. DTI confirms that many callosal connections are homotopic and connect equivalent regions between the two hemispheres (for details see [12]).…”

Section: Commissuresmentioning

confidence: 74%

In Vivo Mapping of Fiber Pathways in the Rhesus Monkey Brain

Hofer¹,

Frahm²

2008

TOMIJ

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The study of complex fiber systems in relation to the cognitive abilities of humans is a long-standing challenge for neuroscientists. With the development of diffusion tensor imaging (DTI) it is now possible to visualize large fiber bundles non-invasively. The existing knowledge of the white matter architecture largely stems from either lesion studies of human patients or, in more detail, tracer injection studies of non-human primates. Hence, it seems mandatory to compare DTI results with histochemical findings obtained for the same species. Using a geometrically undistorted DTI technique and fiber tractography, we examined the fiber anatomy of the macaque brain in vivo and related the results to fiber pathways previously identified in monkeys with conventional tract tracing. The approach identified multiple fiber tracts including the main association and projection pathways as well as fibers of the limbic system, commissural system, optic system, and cerebellar system. In conclusion, in vivo fiber tractography based on current-state DTI allows for a comprehensive analysis of major fiber pathways in the intact macaque brain.

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Section: Commissuresmentioning

confidence: 74%

In Vivo Mapping of Fiber Pathways in the Rhesus Monkey Brain

Hofer¹,

Frahm²

2008

TOMIJ

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“…Largely based on experimental work in monkeys (Pandya et al, 1971;Pandya and Seltzer, 1986;Schmahmann and Pandya, 2006) and a few anatomical studies in humans (van Valkenburg, 1913;de Lacoste et al, 1985), it was long thought that the CMFs connecting M1 of the two hemispheres traverse the human CC in its anterior midbody (Witelson, 1989). However, one TMS study (Meyer et al, 1998) and two recent DTI tractography studies (Hofer and Frahm, 2006;Zarei et al, 2006) strongly suggested that CMFs cross the human CC clearly more posteriorly, in the posterior body of the CC.…”

Section: Topography Of Cmfsmentioning

confidence: 99%

Human Motor Corpus Callosum: Topography, Somatotopy, and Link between Microstructure and Function

Wahl¹,

Lauterbach-Soon²,

Hattingen³

et al. 2007

J. Neurosci.

382

330

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The corpus callosum (CC) is the principal white matter fiber bundle connecting neocortical areas of the two hemispheres. Although an object of extensive research, important details about the anatomical and functional organization of the human CC are still largely unknown. Here we focused on the callosal motor fibers (CMFs) that connect the primary motor cortices (M1) of the two hemispheres. Topography and somatotopy of CMFs were explored by using a combined functional magnetic resonance imaging/diffusion tensor imaging fiber-tracking procedure. CMF microstructure was assessed by fractional anisotropy (FA), and CMF functional connectivity between the hand areas of M1 was measured by interhemispheric inhibition using paired-pulse transcranial magnetic stimulation. CMFs mapped onto the posterior body and isthmus of the CC, with hand CMFs running significantly more anteriorly and ventrally than foot CMFs. FA of the hand CMFs but not FA of the foot CMFs correlated linearly with interhemispheric inhibition between the M1 hand areas. Findings demonstrate that CMFs connecting defined body representations of M1 map onto a circumscribed region in the CC in a somatotopically organized manner. The significant and topographically specific positive correlation between FA and interhemispheric inhibition strongly suggests that microstructure can be directly linked to functional connectivity. This provides a novel way of exploring human brain function that may allow prediction of functional connectivity from variability of microstructure in healthy individuals, and potentially, abnormality of functional connectivity in neurological or psychiatric patients.

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“…The corpus callosum is composed of region-dependent fiber density and myelination levels that reflect its functional specialization (Aboitiz et al, 1992;Highley et al, 1999;Tomasch, 1954;Zaidel and Iacoboni, 2003). The CC has been used as an early and sensitive marker of brain development (Clarke et al, 1989;Georgy et al, 1993;Pandya et al, 1971;Rakic and Yakovlev, 1968), hemispheric lateralization (Witelson and Goldsmith, 1991 Witelson and Goldsmith, 1991). The rostrum (CC1), genu (CC2), and rostral body (CC3) are associated with the units comprising prefrontal and frontal lobe structures.…”

Section: Introductionmentioning

confidence: 99%

Diffusion tensor quantification of the human midsagittal corpus callosum subdivisions across the lifespan

et al. 2008

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The midsagittal corpus callosum (CC) cross-sectional area subdivisions have been used as early and sensitive markers of human brain white matter connectivity, development, natural aging and disease. Despite the simplicity and conspicuity of the appearance of the CC on anatomical magnetic resonance imaging (MRI), the published quantitative MRI literature on its regional sex and age trajectories are contradictory. The availability of noninvasive quantitative methods to assess the CC regions across the human lifespan would help clarify its contribution to behavior and cognition. In this report, we extended the utility of a recently described semi-automated diffusion tensor imaging (DTI) tissue segmentation method to utilize the high orientation contrast of the CC on DTI. Using optimized DTI methods on a cohort of 121 right-handed children and adults aged 6-68 years, we examined the CC areas and corresponding DTI metrics of the different functionally specialized sectors of the CC. Both the area and fractional anisotropy metrics followed inverted U-shaped curves, while the mean and radial diffusivities followed U-curve reflecting white matter progressive and regressive myelination dynamics that continue into young adulthood.

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The topographical distribution of interhemispheric projections in the corpus callosum of the rhesus monkey

Cited by 358 publications

References 13 publications

In Vivo Mapping of Fiber Pathways in the Rhesus Monkey Brain

In Vivo Mapping of Fiber Pathways in the Rhesus Monkey Brain

Human Motor Corpus Callosum: Topography, Somatotopy, and Link between Microstructure and Function

Diffusion tensor quantification of the human midsagittal corpus callosum subdivisions across the lifespan

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