The top ten list of randomized controlled trials in transfusion medicine

Blajchman, Morris A.

doi:10.1111/j.1741-6892.2004.00489.x

Cited by 1 publication

(2 citation statements)

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“…The concept of performing a RCT is not a new one, having been introduced to modern medicine by Sir Anthony Bradford Hill 6 and coworkers in the 1950s to evaluate the efficacy of the antibiotic streptomycin in the treatment of patients with tuberculosis. The use of RCTs to evaluate transfusion medicine interventions, however, have only been used by the transfusion community since the 1980s 7 …”

Section: Levels Of Evidencementioning

confidence: 99%

“…The use of RCTs to evaluate transfusion medicine interventions, however, have only been used by the transfusion community since the 1980s. 7 Over this period of time, fewer than 100 RCTs have been performed to evaluate the various transfusion medicine interventions recommended for use in the treatment of patients. 7 The focus of the transfusion medicine related RCTs has ranged widely and has covered the gamut of transfusion medicine issues.…”

Section: Levels Of Evidencementioning

confidence: 99%

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Landmark studies that have changed the practice of transfusion medicine

Blajchman

2005

Transfusion

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ABBREVIATIONS: FNHTR(s) = febrile nonhemolytic transfusion reaction(s); ICU = intensive care unit; PAD = preoperative autologous blood donation; PLT = platelets; RCT(s) = randomized controlled trial(s); TTP = thrombotic thrombocytopenic purpura; UVA = ultraviolet A; UVB = ultraviolet B.oncerns are often expressed as to whether there is sufficient evidence in a particular medical and/or scientific context to guide clinical or policy decision making. For transfusion medicine, good evidence-based data should be the goal of such informed decision making. Evidence-based medicine is a term that was coined by Dr David Sackett and his colleagues at McMaster University in the late 1980s. 1 The concept of evidence-based medicine includes the process of systematically finding, appraising, and then employing the highest quality of medical and/or scientific research evidence (data) as the basis for informed medical and/or scientific clinical and policy decision making.Evidence-based medicine has also been defined as the integration of the best research evidence with the best clinical expertise (including patient values) to attain good clinical decision making. Thus evidence-based medicine requires the careful application of formal rules of evidence to evaluate the available data in the medical and/or scientific literature. Evidence-based medicine tries to avoid anecdotal clinical experience as well as expert intuition, which are not considered sufficient grounds for good clinical or policy decision making. CThe effective implementation of evidence-based medicine requires that the clinical management of each patient and the establishment of policy be based on the best evidence available at a given point in time. Physicians and scientists who are involved in such decision making, whether policy making or treating individual patients, must acquire the necessary skills to critically assess the scientific evidence, rather than rely on low-level evidence, such as anecdotal reports from previous experience.

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Section: Levels Of Evidencementioning

confidence: 99%

Section: Levels Of Evidencementioning

confidence: 99%