The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis

Holzinger, Dirk; Frosch, Michael; Kastrup, Astrid; Prince, Femke H. M.; Otten, M.H.; Suijlekom-Smit, Lisette W. A. van; Cate, Rebecca ten; Hoppenreijs, Esther P A H; Hansmann, Sandra; Moncrieffe, Halima; Ursu, Simona; Wedderburn, Lucy R.; Roth, Johannes; Foell, Dirk; Wittkowski, Helmut

doi:10.1136/annrheumdis-2011-200598

Cited by 147 publications

(115 citation statements)

References 26 publications

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“…A study by Holzinger et al 104 demonstrated that S100A8 and S100A9 proteins are actively secreted by monocytes at moderate monosodium urate monohydrate (MSU) crystal concentrations. At high MSU crystal concentrations, these proteins are also passively released following neutrophil and monocyte death.…”

Section: Goutmentioning

confidence: 99%

Calprotectin in rheumatic diseases

Ometto

Friso

Astorri

et al. 2016

Exp Biol Med (Maywood)

137

105

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Calprotectin is an acute-phase protein produced by monocytes and neutrophils in the circulation and inflamed tissues. Calprotectin seems to be more sensitive than CRP, being able to detect minimal residual inflammation and is a candidate biomarker in inflammatory diseases. High serum levels are associated with some severe manifestations of rheumatic diseases, such as glomerulonephritis and lung fibrosis. Calprotectin levels in other fluids, such as saliva and synovial fluid, might be helpful in the diagnosis of rheumatic diseases. Of interest is also the potential role of calprotectin as a target of treatment. AbstractCalprotectin is a heterodimer formed by two proteins, S100A8 and S100A9, which are mainly produced by activated monocytes and neutrophils in the circulation and in inflamed tissues. The implication of calprotectin in the inflammatory process has already been demonstrated, but its role in the pathogenesis, diagnosis, and monitoring of rheumatic diseases has gained great attention in recent years. Calprotectin, being stable at room temperature, is a candidate biomarker for the follow-up of disease activity in many autoimmune disorders, where it can predict response to treatment or disease relapse. There is evidence that a number of immunomodulators, including TNF-a inhibitors, may reduce calprotectin expression. S100A8 and S100A9 have a potential role as a target of treatment in murine models of autoimmune disorders, since the direct or indirect blockade of these proteins results in amelioration of the disease process. In this review, we will go over the biologic functions of calprotectin which might be involved in the etiology of rheumatic disorders. We will also report evidence of its potential use as a disease biomarker.

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Section: Goutmentioning

confidence: 99%

Calprotectin in rheumatic diseases

Ometto

Friso

Astorri

et al. 2016

Exp Biol Med (Maywood)

137

105

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“…На экспериментальных моделях артрита был вы-явлен существенный вклад MRP8/14 в развитие воспале-ния и лейкоцитарной инфильтрации [75]. В ряде работ продемонстрирована роль кальпротектина в мониторинге активности болезни, выявления субклинического воспа-ления и прогнозирования обострений болезни [78][79][80]. В работе I. Choi и соавт.…”

Section: кальпротектин (Mrp8/14)unclassified

The Role of Laboratory Biomarkers in Predicting the Efficiency of Rituximab Therapy for Rheumatoid Arthritis: New Evidence

Авдеева¹,

Kusevich²

2017

rsp

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“…These include S100 proteins 37 and serum amyloid A (SAA), 38 promising surrogate biomarkers that serve as non-specific measures of inflammation that may be able to detect subclinical disease activity. 39,40,41 One common advantage to S100 proteins and SAA is their ex-vivo stability. Blood samples can be collected, processed, stored using varying methods and the preanalytical variability has little effect on their measurement.…”

Section: Lessons From Biomarker Discoverymentioning

confidence: 99%