The tolerogenic interplay(s) among HLA-G, myeloid APCs, and regulatory cells

Carosella, Edgardo D.; Gregori, Silvia; LeMaoult, Joël

doi:10.1182/blood-2011-07-370742

Cited by 92 publications

(70 citation statements)

References 57 publications

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“…HLA-G-expressing DC-10 and CD4 + T cells accumulate in human deciduas during pregnancy (45). In addition to direct inhibition of these immune functions, HLA-G promotes long-term tolerance by inducing Tregs (46)(47)(48). Decreased HLA-G expression may induce immune destruction of extravillous trophoblasts.…”

Section: Discussionmentioning

confidence: 99%

Embryonic Trophoblasts Induce Decidual Regulatory T Cell Differentiation and Maternal–Fetal Tolerance through Thymic Stromal Lymphopoietin Instructing Dendritic Cells

Guo

Piao

et al. 2014

The Journal of Immunology

117

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Physiological pregnancy requires the maternal immune system to recognize and tolerate embryonic Ags. Although multiple mechanisms have been proposed, it is not yet clear how the fetus evades the maternal immune system. In this article, we demonstrate that trophoblast-derived thymic stromal lymphopoietin (TSLP) instructs decidual CD11c+ dendritic cells (dDCs)with increased costimulatory molecules; MHC class II; and Th2/3-type, but not Th1-type, cytokines. TSLP-activated dDCs induce proliferation and differentiation of decidual CD4+CD25− T cells into CD4+CD25+FOXP3+ regulatory T cells (Tregs) through TGF-β1. TSLP-activated dDC–induced Tregs display immunosuppressive features and express Th2-type cytokines. In addition, decidual CD4+CD25+FOXP3+ Tregs promote invasiveness and HLA-G expression of trophoblasts, resulting in preferential production of Th2 cytokines and reduced cytotoxicity in decidual CD56brightCD16− NK cells. Of interest, decreased TSLP expression and reduced numbers of Tregs were observed at the maternal–fetal interface during miscarriage. Our study identifies a novel feedback loop between embryo-derived trophoblasts and maternal decidual leukocytes, which induces a tolerogenic immune response to ensure a successful pregnancy.

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Section: Discussionmentioning

confidence: 99%

Embryonic Trophoblasts Induce Decidual Regulatory T Cell Differentiation and Maternal–Fetal Tolerance through Thymic Stromal Lymphopoietin Instructing Dendritic Cells

Guo

Piao

et al. 2014

The Journal of Immunology

117

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“…toward both innate and acquired immunity (3,4). The immune-inhibitory properties of HLA-G are believed to be beneficial in pregnancy, in organ transplantation, and in autoimmune diseases by promoting uterine implantation of the embryo, accepting solid allografts, and turning down reaction against self-components, respectively (1,2).…”

mentioning

confidence: 99%

Soluble Human Leukocyte Antigen-G and Its Insertion/Deletion Polymorphism in Papillary Thyroid Carcinoma: Novel Potential Biomarkers of Disease?

Dardano

Rizzo

Polini

et al. 2012

The Journal of Clinical Endocrinology & Metabolism

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Although confirming the frequent association between PTC and chronic autoimmune thyroiditis, these data suggest that elevated circulating sHLA-G levels, besides an important signal of alterations of immune homeostasis, may be considered a potential, novel marker of PTC histopathological aggressiveness at diagnosis. Additional studies are needed to confirm the actual role and clinical relevance of the HLA-G complex in PTC development and progression.

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“…Majority of the in vivo functions of HLA-G are executed by the myeloid antigen-presenting cells, as these have the ability to interact with complete spectrum of HLA-G isoforms [33]. We hypothesized that Mtb infected macrophages could lead to the upregulation of HLA-G expression in TB patients and observed the same in TB-PE patients in comparison to MTB and PTB.…”

Section: Discussionmentioning

confidence: 88%

Differential expression of HLA-G and ILT-2 receptor in human tuberculosis: Localized versus disseminated disease

et al. 2016

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The tolerogenic interplay(s) among HLA-G, myeloid APCs, and regulatory cells

Cited by 92 publications

References 57 publications

Embryonic Trophoblasts Induce Decidual Regulatory T Cell Differentiation and Maternal–Fetal Tolerance through Thymic Stromal Lymphopoietin Instructing Dendritic Cells

Embryonic Trophoblasts Induce Decidual Regulatory T Cell Differentiation and Maternal–Fetal Tolerance through Thymic Stromal Lymphopoietin Instructing Dendritic Cells

Soluble Human Leukocyte Antigen-G and Its Insertion/Deletion Polymorphism in Papillary Thyroid Carcinoma: Novel Potential Biomarkers of Disease?

Differential expression of HLA-G and ILT-2 receptor in human tuberculosis: Localized versus disseminated disease

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