The TLR9 Gene Polymorphisms and the Risk of Cancer: Evidence from a Meta-Analysis

Zhang, Lushun; Qin, Haojie; Guan, Xuan; Zhang, Kui; Liu, ZhiRong

doi:10.1371/journal.pone.0071785

Cited by 28 publications

(19 citation statements)

References 46 publications

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“…Similar trend of higher frequency of T allele was also reported in Japanese (100%), Koreans (100%), Chinese (99.5%) and Indians (90%) (Tao et al, 2007;Hur et al, 2005;Ng et al, 2005;Aditya et al, 2013). However, Caucasians of European origin were reported to have variable frequency between 83 and 93% (Zhang et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Susceptibility to SLE in South Indian Tamils may be influenced by genetic selection pressure on TLR2 and TLR9 genes

Devaraju¹,

Gulati²,

Antony³

et al. 2015

Molecular Immunology

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Section: Discussionmentioning

confidence: 99%

Susceptibility to SLE in South Indian Tamils may be influenced by genetic selection pressure on TLR2 and TLR9 genes

Devaraju¹,

Gulati²,

Antony³

et al. 2015

Molecular Immunology

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“…However, the results are inconsistent and inconclusive. The link between TLR-9 polymorphisms and cancer was specifically investigated in the context of chronic inflammation, which is thought to increase the risk of cancer 30. Most previous studies have focused on three common single-nucleotide polymorphisms (SNPs), ie, rs352140 (C/T), rs5743836 (T/C), and rs187084 (C/T) (also referred to as 2848C/T, 1237T/C, and 1486C/T, respectively); however, the results of these studies were inconsistent 30…”

Section: Introductionmentioning

confidence: 99%

Association between <em>TLR-9</em> polymorphisms and colon cancer susceptibility in Saudi Arabian female patients

Semlali

Parine

Amri

et al. 2016

OTT

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ObjectiveThe authors aimed to explore the relationship between the expression/polymorphisms of TLR-9 and susceptibility to colon cancer development in the Saudi Arabian population.MethodsIn total, blood samples from 115 patients with colon cancer and 102 participants without colon cancer were analyzed in this study. Three single-nucleotide polymorphisms (SNPs) were selected from the TLR-9 gene, including two sites within the TLR-9 gene’s promoter region (rs352144 and rs187084) and one site in a TLR-9 intron region (rs5743839). Odds ratios (ORs) and 95% confidence intervals (CIs) were computed from logistic regression models after adjusting for age, gender, and tumor localization. To investigate the differential expression of TLR-9 in colon cancer, TLR-9 expression was evaluated using quantitative real-time reverse transcription polymerase chain reaction on 40 matched normal and colon tissues.ResultsThe authors found that TLR-9 expression was decreased in colon cancer tissues as compared with that in normal tissues. Moreover, significant associations between the TLR-9 rs187084 SNP and colon cancer risk were observed in female patients only. In rs187084, the T allele had a significantly lower frequency (2.8 times) in female cancer patients than in controls (0.27 vs 0.41). The TLR-9 rs352139 and rs352144 SNPs were significantly associated with colon cancer development when the tumor was located in the rectal area.ConclusionThe findings support the hypothesis that TLR-9 has an anticancer role in colon cancer development. Furthermore, genetic variation may influence colon cancer development, and SNPs in TLR-9 could serve as biomarkers for decision making in the treatment of females with rectal cancer.

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“…Patients with chronic HBV infection were enrolled in this study (n = 1191, female, 424; male, 767; median age, 36; range, [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42], and the control population demonstrated previous HBV clearance (n = 273; female, 111; male, 162; median age, 42; range, 33-49). A significant difference was found between HBV clearance and chronic HBV infection for age (P < 0.0001).…”

Section: Patientsmentioning

confidence: 99%

Interaction of TLR–IFN and HLA polymorphisms on susceptibility of chronic HBV infection in Southwest Han Chinese

Shen

Guo

et al. 2015

Liver International

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Background & Aims: The toll-like receptor-interferon (TLR-IFN) signalling pathway plays a crucial role in HBV infection. Human leucocyte antigen (HLA) polymorphisms are associated with chronic HBV infection by genome wide association study (GWAS). We aimed to explore interaction between TLR-IFN and HLA gene polymorphisms in susceptibility of chronic HBV infection. Methods: In the Chinese Southwest Han population, 1191 chronic HBV infection patients and 273 HBV clearance were selected. A total of 39 single nucleotide polymorphism loci in 23 genes of the TLR-IFN pathway and four HLA polymorphism loci associated with chronic HBV infection identified by GWAS were selected for genotyping. SNPStats, QVALUE, and multifactor dimensionality reduction were used for statistical analysis. Results: A significant association was seen in several of the TLR-IFN pathway genes, TLR9 rs352140 (OR = 0.70, P = 0.0088), IL1B rs16944 (OR = 0.67, P = 0.016), IL12B rs3212227 (OR = 1.38, P = 0.021), IFNGR1 rs3799488 (OR = 1.48, P = 0.0048), IFNGR2 rs1059293 (OR = 0.27, P = 0.011), MX1 rs467960 (OR = 0.68, P = 0.022), as well as four loci in HLA, rs3077 (OR = 0.55, P < 0.0001), rs2856718 (OR = 0.60, P = 4e-04), rs9277535 (OR = 0.54, P < 0.0001) and rs7453920 (OR = 0.43, P < 0.0001). A synergistic relationship was seen between rs9277535 and rs16944 (0.13%), rs1143623 and rs6613 (0.10%). The combination of rs9277535 in HLA and rs16944 in IL1B was the best model to predict chronic HBV infection (testing accuracy = 0.6040, P = 0.0010, cross-validation consistency = 10/10). Conclusions: TLR-IFN pathway gene polymorphisms are associated with chronic HBV infection. Interactions with polymorphisms in these genes may be one mechanism by which HLA polymorphisms influence susceptibility to chronic HBV infection, as specific single nucleotide polymorphism combinations are highly predictive of chronic HBV infection.

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The TLR9 Gene Polymorphisms and the Risk of Cancer: Evidence from a Meta-Analysis

Cited by 28 publications

References 46 publications

Susceptibility to SLE in South Indian Tamils may be influenced by genetic selection pressure on TLR2 and TLR9 genes

Susceptibility to SLE in South Indian Tamils may be influenced by genetic selection pressure on TLR2 and TLR9 genes

Association between <em>TLR-9</em> polymorphisms and colon cancer susceptibility in Saudi Arabian female patients

Interaction of TLR–IFN and HLA polymorphisms on susceptibility of chronic HBV infection in Southwest Han Chinese

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