The TLR4 gene polymorphisms and susceptibility to cancer: A systematic review and meta-analysis

Zhang, Kui; Zhou, Bin; Wang, Yanyun; Li, Rao; Zhang, Lin

doi:10.1016/j.ejca.2012.09.022

Cited by 82 publications

(63 citation statements)

References 36 publications

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“…Three previous pooled analyses (Lindström et al, 2010;Chen et al, 2013;Zhang et al, 2013) found no positive association between rs11536889 and cancer. It should be noted that they comprised a limited number of studies: Zhang et al (2013) included eight, Lindström et al (2010) included three, and Chen et al (2013) included two studies.…”

Section: Discussionmentioning

confidence: 99%

“…Many single nucleotide polymorphisms (SNPs) have been identified in TLR4, although the functional effects of most of them have not been revealed (Kutikhin, 2011). To date, many epidemiological studies investigating the association between TLR4 genetic variants and cancer risk have been published; however, the results are conflicting (Chen et al, 2013;Zhang et al, 2013;Zhu et al, 2013;Zou et al, 2013). To the best of our knowledge, three SNPs of TLR4, rs4986790 (Asp299Gly), rs4986791 (Thr399Ile), and rs11536889 (3725G>C), remain the most described and studied in relation to cancer risk.…”

Section: Introductionmentioning

confidence: 96%

“…It is noteworthy that in Asian populations, rs4986790 and rs4986791 are uncommon or even absent. In contrast, the prevalence of rs11536889 in Asian populations is as high as in Western populations (Cheng et al, 2007;Zhang et al, 2013). To date, the relationship between rs11536889 and cancer risk is inconclusive.…”

Section: Introductionmentioning

confidence: 99%

“…These three polymorphisms have been investigated for their potential associations with the risk of different cancers such as prostate, gastric, and hepatocellular cancer. More than five metaanalyses have been published regarding the association of rs4986790 and rs4986791 with cancer risk (Lindström et al, 2010;Chen et al, 2013;Zhang et al, 2013;Zhu et al, 2013;Zou et al, 2013). It is noteworthy that in Asian populations, rs4986790 and rs4986791 are uncommon or even absent.…”

Section: Introductionmentioning

confidence: 99%

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Pooled analysis of association between a genetic variant in the 3'-untranslated region of Toll-like receptor 4 and cancer risk

Wang

Miao

2015

Genet. Mol. Res.

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ABSTRACT. Many epidemiological studies have shown the association between certain genetic variations in the Toll-like receptor 4 (TLR4) gene (for example, rs4986790 and rs4986791) and cancer risk. However, the results from investigations into the association between rs11536889, a genetic variant in the 3'-untranslated region of TLR4, and cancer risk lack consensus. We performed a meta-analysis to investigate the effect of rs11536889 on cancer risk. A total of 12 relevant case-control studies were included in this analysis (6222 cases and 7948 controls). The pooled ORs with their corresponding 95%CIs were estimated. We did not detect any association between rs11536889 and overall cancer risk (P = 0.13). However, stratification analysis by cancer type revealed a borderline statistically significant increased risk in both genotype comparison (OR for the variant genotype in the dominant model = 1.17; 95%CI = 0.98-1.40; P = 0.08) and allele comparison (OR for variant allele = 1.14; 95%CI = 0.99-1.32; P = 0.07) for prostate cancer. In contrast, no statistically significant or borderline result was found for gastric cancer. These findings indicate that rs11536889 in TLR4 might be specifically associated with prostate 17848 X. Wang et al.©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 17847-17855 (2015) cancer. However, owing to the modest and underpowered results, and the limitations of the original studies included for analysis, further prospective studies with larger sample sizes are required to confirm our findings.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pooled analysis of association between a genetic variant in the 3'-untranslated region of Toll-like receptor 4 and cancer risk

Wang

Miao

2015

Genet. Mol. Res.

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“…[6][7][8][9][10][11][12][13] SsnB, therefore, is a promising lead for the development of selective TLR antagonist for inammation control. But the low content of SsnB in plants hampered further studies, which attracted us to develop efficient and practical synthetic methods to prepare SsnB.…”

mentioning

confidence: 99%

Total synthesis of Sparstolonin B, a potent anti-inflammatory agent

Wang

et al. 2015

RSC Adv.

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Two concise routes for the first total synthesis of Sparstolonin B (SsnB) have been described. The synthesis of SsnB could be accomplished in 5 and 6 steps with 40% and 38% overall yield, respectively. The rhodium-catalysed oxidative coupling of benzoic acid with internal alkyne was used in both strategies to construct the core structure of SsnB.Sparstolonin B (SsnB) is the rst novel bioactive natural small molecule, isolated from a Chinese herb, Sparganium stoloniferum, by Liang and coworkers, which selectively blocks toll-like receptors 2 (TLR2) and TLR4 mediated inammatory signalling by inhibiting the recruitment of MyD88 to the Toll/Il-1 receptor homologue domains of TLR2 and TLR4.

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Pattern Recognition Receptors and Aging

Shalaby

2013

Immunology of Aging

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The TLR4 gene polymorphisms and susceptibility to cancer: A systematic review and meta-analysis

Cited by 82 publications

References 36 publications

Pooled analysis of association between a genetic variant in the 3'-untranslated region of Toll-like receptor 4 and cancer risk

Pooled analysis of association between a genetic variant in the 3'-untranslated region of Toll-like receptor 4 and cancer risk

Total synthesis of Sparstolonin B, a potent anti-inflammatory agent

Pattern Recognition Receptors and Aging

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