The titration of antipneumococcus serum

Smith, Wilson

doi:10.1002/path.1700350404

Cited by 16 publications

(5 citation statements)

References 12 publications

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“…With these limitations the optimal proportions method serves as a convenient one for the comparison of sera when only approximate, relative values are desired, but it becomes extremely cumbersome when attempts are made to endow it with quantitative significance (c/. 15,16).…”

Section: Discussionmentioning

confidence: 99%

Chemical Studies on Bacterial Agglutination

Heidelberger

Kabat

1934

Journal of Experimental Medicine

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Section: Discussionmentioning

confidence: 99%

Chemical Studies on Bacterial Agglutination

Heidelberger

Kabat

1934

Journal of Experimental Medicine

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“…A similar advantage of the use of graded immunizing doses methods has been observed in passive immunity experiments. Smith (26) found marked superi-ority of this method in determining the mouse protective potency of antipneumococcal sera. Batson (27), in a direct comparison of the effects of graded serum doses and challenge doses in the titration of the mouse protective potencies of typhoid antisera, obtained similar results.…”

Section: Discussionmentioning

confidence: 99%

The Relative Significance of Graded Immunizing and Challenge Doses in Measuring the Potency of Vaccines

Batson¹

1949

Journal of Experimental Medicine

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A study of the effect of graded immunizing doses of typhoid vaccine and graded challenge doses of S. typhosa in 5 per cent mucin on the degree of gradation of response (survival or death) elicited in successive groups of mice is reported. In the range of doses employed the effect of graded immunizing doses was markedly greater than was the effect of graded challenge doses. Statistically the difference exceeded the 0.1 per cent level of significance. It was concluded that the use of graded immunizing doses was preferable to the use of graded challenge doses as a basis for the immunological assay of typhoid vaccine, since with the former there was obtained (a) a greater significance of differences in response of groups given graded doses even with smaller fold increments in successive doses, (b) a greater slope of the dosage-response curve which permitted estimation of ED50 values with smaller standard errors, and (c) an effect on response apparently less dependent on the sex of mice used.

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“…Specific examples of experiments of the type we are interested in are available in different areas of application. Smith (1932) describes a bioassay for an antipneumococcus serum where the explanatory variable is doses of the serum. Mice infected with pneumococcus are injected with different doses of the serum and the response is survival (or not) beyond seven days.…”

Section: Introductionmentioning

confidence: 99%

Optimal Designs for Two-Level Factorial Experiments with Binary Response

Mandal¹,

Yang²,

Majumdar³

2010

Preprint

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We consider the problem of obtaining locally D-optimal designs for factorial experiments with qualitative factors at two levels each with binary response. Our focus is primarily on the 2 2 experiment. In this paper, we derive analytic results for some special cases and indicate how to handle the general case. The performance of the uniform design in examined and we show that this design is highly efficient in general. For the general 2 k case we show that the uniform design has a maximin property.

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The titration of antipneumococcus serum

Cited by 16 publications

References 12 publications

Chemical Studies on Bacterial Agglutination

Chemical Studies on Bacterial Agglutination

The Relative Significance of Graded Immunizing and Challenge Doses in Measuring the Potency of Vaccines

Optimal Designs for Two-Level Factorial Experiments with Binary Response

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