The tissue residue approach for toxicity assessment: Findings and critical reviews from a Society of Environmental Toxicology and Chemistry Pellston Workshop

Meador, James P.; Adams, William J.; Escher, Beate I.; McCarty, L.S.; McElroy, Anne E.; Sappington, Keith

doi:10.1002/ieam.133

Cited by 51 publications

(42 citation statements)

References 9 publications

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“…It is well established that PCBs bioaccumulate in tissues (Veith et al 1983(Veith et al , 1979Safe 1994;Meador et al 2011), and the use of a tissue residue approach as an exposure metric provides the most direct connection to the observed effects . It is well established that PCBs bioaccumulate in tissues (Veith et al 1983(Veith et al , 1979Safe 1994;Meador et al 2011), and the use of a tissue residue approach as an exposure metric provides the most direct connection to the observed effects .…”

Section: Data Identificationmentioning

confidence: 99%

Polychlorinated biphenyl tissue‐concentration thresholds for survival, growth, and reproduction in fish

Berninger

Tillitt

2019

Enviro Toxic and Chemistry

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Polychlorinated biphenyls (PCBs) have left a legacy of environmental contamination. Even though they were banned from production and active use in the 1970s, they persist in the environment and still have the potential to impact aquatic life. Our objective was to identify data from controlled laboratory studies of PCB‐related adverse effects in fish and to conduct a meta‐analysis on mortality, growth, and reproductive (MGR) threshold responses. For each endpoint type, we compiled data on the lowest‐observed‐adverse effect concentration (LOAEC) and the degree of effect at the LOAEC as a percentage of control. The LOAECs were expressed as tissue concentrations, so the term lowest‐observed‐adverse‐effect residue concentration (LOAER) was used to represent PCB exposures. The lower limit of applicability was set at 0.1 μg/g total PCB tissue concentration, below which adverse MGR effects in fish were not supported by the data. Sensitivity distributions identifying the probability of adverse effects in fish populations or communities predicted that 25% of fish species would be impacted between 0.1 and 7.5 μg/g. Concentration–response threshold regressions were developed from the MGR datasets. For example, a 1 μg/g total PCB tissue concentration would predict effects of 17% mortality, 15% growth, and 39% reproductive. The analysis determined the degree of adverse response, with uncertainty estimates, expected across a broad range of PCB tissue exposure concentrations in fish. Data generated from MGR endpoints were combined to determine an approach for overall effect thresholds for PCB‐related injury in fish. The MGR datasets included only laboratory data; however, responses were compared with field‐observed effects. The present review provides a comprehensive assessment of PCB‐induced injury in fish utilizing a data‐inclusive approach. Environ Toxicol Chem 2019;38:712–736. Published 2018 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.

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Section: Data Identificationmentioning

confidence: 99%

Polychlorinated biphenyl tissue‐concentration thresholds for survival, growth, and reproduction in fish

Berninger

Tillitt

2019

Enviro Toxic and Chemistry

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“…As a surrogate, the total concentration in an organism that elicits a critical effect, termed the critical body residue (CBR), has been used. CBR is defined as the molar concentration per body weight of the organism that elicits a defined (e.g., lethal) toxic endpoint (Escher and Hermens, 2002;Meador et al, 2011).…”

Section: Effect Of Kineticsmentioning

confidence: 99%

Relationship between lethal toxicity in oral administration and injection to mice: Effect of exposure routes

Wang

Ning

Tai

et al. 2015

Regulatory Toxicology and Pharmacology

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“…The major findings are summarized in Meador et al (2011). The major findings are summarized in Meador et al (2011).…”

Section: Relationship Between Bioaccumulated Concentrations and Noxiomentioning

confidence: 99%

From Incorporation to Toxicity

Amiard‐Triquet¹

2015

Aquatic Ecotoxicology

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The tissue residue approach for toxicity assessment: Findings and critical reviews from a Society of Environmental Toxicology and Chemistry Pellston Workshop

Cited by 51 publications

References 9 publications

Polychlorinated biphenyl tissue‐concentration thresholds for survival, growth, and reproduction in fish

Polychlorinated biphenyl tissue‐concentration thresholds for survival, growth, and reproduction in fish

Relationship between lethal toxicity in oral administration and injection to mice: Effect of exposure routes

From Incorporation to Toxicity

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