The Tissue Clock Network: Driver and Gatekeeper of Circadian Physiology

Harder, Lisbeth; Oster, Henrik

doi:10.1002/bies.201900158

Cited by 18 publications

(9 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The peripheral muscle clock, in turn, integrates these signals by sensing, interpreting, and responding to cues primarily from the central clock, and potentially from other peripheral clocks, to ensure tissue coherence. This unexpected gatekeeping function of the peripheral clock over the central clock supports the federated model of clock organization, which suggests that there is a decentralized network of clocks rather than a hierarchical, brain-centric network with the central clock solely controlling peripheral tissue clocks ( 59 , 75 ). The gatekeeper functions of the peripheral clocks are likely crucial for tissue health and overall organism function ( 76 , 77 ).…”

Section: Discussionsupporting

confidence: 56%

Brain-muscle communication prevents muscle aging by maintaining daily physiology

Kumar,

Vaca-Dempere,

Mortimer

et al. 2024

Science

View full text Add to dashboard Cite

A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, we created a basic clock module involving a central and a peripheral (muscle) clock. Reconstituting the brain-muscle clock network is sufficient to preserve fundamental daily homeostatic functions and prevent premature muscle aging. However, achieving whole muscle physiology requires contributions from other peripheral clocks. Mechanistically, the muscle peripheral clock acts as a gatekeeper, selectively suppressing detrimental signals from the central clock while integrating important muscle homeostatic functions. Our research reveals the interplay between the central and peripheral clocks in daily muscle function and underscores the impact of eating patterns on these interactions.

show abstract

Section: Discussionsupporting

confidence: 56%

Brain-muscle communication prevents muscle aging by maintaining daily physiology

Kumar,

Vaca-Dempere,

Mortimer

et al. 2024

Science

View full text Add to dashboard Cite

show abstract

“…Mammals possess a hierarchical circadian system with a central oscillator, the suprachiasmatic nucleus (SCN), localized in the hypothalamus [3]. The primary role of SCN is to provide subordinate clocks in the brain and peripheral tissues, through several pathways (See "Overview of SCN-driven inputs to peripherel clocks"), with temporal information aligning a multitude of clock-associated biological processes to a single time zone shared by the entire organism in line with the cyclic demands posed by the environment [4][5][6][7][8][9]. Disbalance or disruption of this temporal harmony has been shown to contribute to the development and progression of several diseases [2,5,10,11].…”

Section: How Organisms Keep Track Of Timementioning

confidence: 99%

The circadian clock and metabolic homeostasis: entangled networks

Assis

Oster

2021

Cell. Mol. Life Sci.

Self Cite

View full text Add to dashboard Cite

The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of time for the organism. The synchrony between the daily challenges imposed by the environment needs to be aligned with biological processes and with the internal circadian clock. In this review, it is provided an in-depth view of the molecular functioning of the circadian molecular clock, how this system is organized, and how central and peripheral clocks communicate with each other. In this sense, we provide an overview of the neuro-hormonal factors controlled by the central clock and how they affect peripheral tissues. We also evaluate signals released by peripheral organs and their effects in the central clock and other brain areas. Additionally, we evaluate a possible communication between peripheral tissues as a novel layer of circadian organization by reviewing recent studies in the literature. In the last section, we analyze how the circadian clock can modulate intracellular and tissue-dependent processes of metabolic organs. Taken altogether, the goal of this review is to provide a systemic and integrative view of the molecular clock function and organization with an emphasis in metabolic tissues.

show abstract

“…As one example, in mouse liver, 16 % of all protein-coding genes were found to be rhythmically expressed, though only a fraction of these seem to be directly regulated by the local clock machinery (Zhang et al 2014, Greenwell et al 2019. Others respond rather to systemic rhythmic factors such as hormones, feeding-related signals or body temperature (Harder & Oster 2020). This complex interaction of external and local signal in the temporal regulation of the metabolic…”

Section: Clocks and Metabolismmentioning

confidence: 99%

The interplay between stress, circadian clocks, and energy metabolism

Oster

2020

Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

Endogenous circadian clocks adapt an organism’s physiology and behavior to predictable changes in the environment as a consequence of the Earth’s rotation around its axis. In mammals, circadian rhythms are the output of a ubiquitous network of cellular timers coordinated by a hypothalamic master pacemaker. Circadian clock function is closely connected to the stress response system which has evolved to ensure survival under less predictable situations of danger. Disruptions in both of these functions are highly prevalent in modern society and have been linked to pathologic alterations in metabolic setpoints, promoting overeating, obesity, and type-2 diabetes. This paper describes the different levels of interaction between the circadian clock and acute and chronic stress responses. It summarizes studies assessing clock-stress crosstalk in the context of metabolic homeostasis and outlines options to use this interaction for diagnostic and therapeutic measures targeting metabolic health and well-being in the highly chronodisruptive environment of modern 24-hour globalized societies.

show abstract

The Tissue Clock Network: Driver and Gatekeeper of Circadian Physiology

Cited by 18 publications

References 68 publications

Brain-muscle communication prevents muscle aging by maintaining daily physiology

Brain-muscle communication prevents muscle aging by maintaining daily physiology

The circadian clock and metabolic homeostasis: entangled networks

The interplay between stress, circadian clocks, and energy metabolism

Contact Info

Product

Resources

About