The tiny big world of solid lipid nanoparticles and nanostructured lipid carriers: an updated review

Abdel-Mageed, Heidi M.; Aziz, Amira E. Abd El; Mohamed, Saleh A.; Abuelezz, Nermeen Z.

doi:10.1080/02652048.2021.2021307

Cited by 23 publications

(18 citation statements)

References 98 publications

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“…They have some distinct advantages that facilitate their wider applications for oral, parenteral, intranasal, ocular, transdermal, and pulmonary drug delivery [ 44 , 45 , 46 ]. The components of SLNs and NLCs are physiologically biocompatible and biodegradable lipids and other excipients that are generally recognized as safe (GRAS), making them safe nano-drug delivery systems [ 47 , 48 ]. SLNs and NLCs are more stable than micelles, emulsions, or liposomes because their solid matrices can protect incorporated drugs more efficiently [ 49 ].…”

Section: Nose-to-brain Delivery Pathways and Feasibilities Of Slns An...mentioning

confidence: 99%

Pharmacokinetics and Pharmacodynamics of Intranasal Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Nose-to-Brain Delivery

Nguyen

Maeng

2022

Pharmaceutics

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Nose-to-brain drug delivery has been of great interest for the treatment of many central nervous system (CNS) diseases and psychiatric disorders over past decades. Several nasally administered formulations have been developed to circumvent the blood-brain barrier and directly deliver drugs to the CNS through the olfactory and trigeminal pathways. However, the nasal mucosa’s drug absorption is insufficient and the volume of the nasal cavity is small, which, in combination, make nose-to-brain drug delivery challenging. These problems could be minimized using formulations based on solid lipid nanoparticles (SLNs) or nanostructured lipid carriers (NLCs), which are effective nose-to-brain drug delivery systems that improve drug bioavailability by increasing drug solubility and permeation, extending drug action, and reducing enzymatic degradation. Various research groups have reported in vivo pharmacokinetics and pharmacodynamics of SLNs and NLCs nose-to-brain delivery systems. This review was undertaken to provide an overview of these studies and highlight research performed on SLN and NLC-based formulations aimed at improving the treatment of CNS diseases such neurodegenerative diseases, epilepsy, and schizophrenia. We discuss the efficacies and brain targeting efficiencies of these formulations based on considerations of their pharmacokinetic parameters and toxicities, point out some gaps in current knowledge, and propose future developmental targets.

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Section: Nose-to-brain Delivery Pathways and Feasibilities Of Slns An...mentioning

confidence: 99%

Pharmacokinetics and Pharmacodynamics of Intranasal Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Nose-to-Brain Delivery

Nguyen

Maeng

2022

Pharmaceutics

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“…e food industry concentrates on using bioactive compounds because of the growing interest in doing so to maintain product quality and safety, as well as the benefits they have for human health and the environment [23]. Next, a discussion of applications and functionalization strategies for the administration of therapeutics via various delivery methods [24]. Natto has numerous health benefits, including the ability to control blood cholesterol levels, prevent arterial sclerosis, heart disease, and hypertension, promote bone growth, control the bacterial balance in the intestines, prevent diarrhea, enteritis, and constipation, improve immunity, fat reduction, beauty treatment, eye relief, and so on [25].…”

Section: Nutritional Compositionmentioning

confidence: 99%

Nutritional Health Perspective of Natto: A Critical Review

Afzaal

Saeed

Islam

et al. 2022

Biochemistry Research International

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Natto, a traditional soy food fermented by Bacillus subtilis, is made by steaming or cooking soaked soybean seeds, inoculating them with the bacteria, and then letting them sit for an incubation period. Natto soya has grown popular because of its nutritional importance and health advantages. As a result, farmers have more opportunities, thanks to the natto soybean market. For the natto soybean market to remain stable and grow, improved soybean cultivars with enhanced natto quality traits are essential. Natto’s high-quality attributes are influenced by the bacteria strain, processing parameters, and soybean variety. Natto has a specific flavor and aroma with a slimy, sticky consistency. Natto possesses various therapeutic potentials and contains a range of essential nutrients and bioactive compounds, i.e., nattokinase, soybean isoflavone, γ-polyglutamic acid, vitamin K2, and biogenic amines. Bacterial species, processing conditions, and cultivars of soybean determine the quality characteristics of natto. Natto food is higher in menaquinone-7 and contains 100 times more menaquinone-7 than most cheeses. The present review highlights the production technology, microbiology, nutritional composition, and therapeutic potentials of natto.

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“…Lip was immobilized by entrapping in the Alg-Gel hydrogel matrix with modifications to the previously reported methodology (Abdel-Mageed et al 2022b). After alginate and gelatin (2%W/V) were dissolved in potassium phosphate buffer (pH:7.0, 50 mM) at 45 °C, a homogenous mixture solution was prepared.…”

Section: Immobilization Procedures Of Lip In the Hydrogel Matrixmentioning

confidence: 99%

“…One downside of gelatin is its reversible gelation, which renders it effectively immobilized only at temperatures between 30 and 35 °C. Various strategies including the use of cross-linking agents have been investigated to achieve an irreversible gelation process (Abdel-Mageed et al 2022b;Chen et al 2020). In this study, glutaraldehyde was chosen as the cross-linker agent.…”

Section: Introductionmentioning

confidence: 99%

Optimization of catalytic properties of Mucor racemosus lipase through immobilization in a biocompatible alginate gelatin hydrogel matrix for free fatty acid production: a sustainable robust biocatalyst for ultrasound-assisted olive oil hydrolysis

et al. 2022

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Immobilization is a key technology that improves the operational stability of enzymes. In this study, alginate-gelatin (Alg-Gel) hydrogel matrix was synthesized and used as immobilization support for Mucor racemosus lipase (Lip). Enzyme catalyzed ultrasound-assisted hydrolysis of olive oil was also investigated. Alg-Gel matrix exhibited high entrapment efficiency (94.5%) with a degradation rate of 42% after 30 days. The hydrolysis of olive oil using Alg-Gel-Lip increased significantly (P < 0.05) as compared to free Lip. Optimum pH and temperature were determined as pH 5.0 and 40 °C, respectively. The Vmax values for free and immobilized Lip were determined to be 5.5 mM and 5.8 mM oleic acid/min/ml, respectively, and the Km values were 2.2 and 2.58 mM/ml respectively. Thermal stability was highly improved for Alg-Gel-Lip (t1/2 650 min and Ed 87.96 kJ/mol) over free Lip (t1/2 150 min and Ed 23.36 kJ/mol). The enzymatic activity of Alg-Gel-Lip was preserved at 96% after four consecutive cycles and 90% of the initial activity after storage for 60 days at 4 °C. Alg-Gel-Lip catalyzed olive oil hydrolysis using ultrasound showed a significant (P < 0.05) increase in hydrolysis rate compared to free Lip (from 0.0 to 58.2%, within the first 2 h). In contrast to traditional methodology, using ultrasonic improved temperature-dependent enzymatic catalyzed reactions and delivered greater reaction yields. Results suggest that Alg-Gel-Lip biocatalyst has great industrial application potential, particularly for free fatty acid production. In addition, the combined use of enzyme and ultrasound has the potential of eco-friendly technology.

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The tiny big world of solid lipid nanoparticles and nanostructured lipid carriers: an updated review

Cited by 23 publications

References 98 publications

Pharmacokinetics and Pharmacodynamics of Intranasal Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Nose-to-Brain Delivery

Pharmacokinetics and Pharmacodynamics of Intranasal Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Nose-to-Brain Delivery

Nutritional Health Perspective of Natto: A Critical Review

Optimization of catalytic properties of Mucor racemosus lipase through immobilization in a biocompatible alginate gelatin hydrogel matrix for free fatty acid production: a sustainable robust biocatalyst for ultrasound-assisted olive oil hydrolysis

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